Primary Outcomes
Measure: Time to clinical improvement from day 0 to day 28 (improvement of two points on a seven-category ordinal scale, or live discharge from the hospital, whichever comes first) Time: from day 0 to day 28 or hospital discharge
Secondary Outcomes
Measure: Primary safety endpoint: major adverse cardiac events defined as the composite of cardiovascular death, myocardial infarction, stroke or acute heart failure at day 28 Time: at day 28
Measure: Clinical status as assessed with the seven-category ordinal scale on days 7, 14 and 28. Time: at days 7, 14 and 28
Measure: Number of days alive free of oxygen. Time: from day 0 to day 28 or hospital discharge
Measure: Number of days alive outside hospital until day28 Time: at day28
Measure: Number of days alive free of intensive-care unit (ICU) admission or mechanical ventilation (invasive or non-invasive) until day28 Time: at day28
Measure: Number of days alive free of mechanical ventilation (invasive or non-invasive) until day28 Time: at day28
Measure: Number of days alive free of ICU admission until day28 Time: at day28
Measure: Rate of all-cause mortality at day 28 Time: at day 28
Measure: Rate of cardiovascular death at day 28 Time: at day 28
Measure: Number of days alive free of acute kidney injury until hospital discharge Time: at day 28 to hospital discharge