CovidResearchTrials by Shray Alag


CovidResearchTrials Covid 19 Research using Clinical Trials (Home Page)


Ketogenic dietWiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (3)


Name (Synonyms) Correlation
drug711 SAB-301 Wiki 1.00
drug565 Normal (9%) Saline Wiki 1.00
drug1025 standard of care Wiki 1.00

Correlated MeSH Terms (1)


Name (Synonyms) Correlation
D018352 Coronavirus Infections NIH 0.06

Correlated HPO Terms (0)


Name (Synonyms) Correlation

There is one clinical trial.

Clinical Trials


1 Keto-diet for Intubated Critical Care COVID-19 (KICC-COVID19)

Coronavirus disease (COVID-2019) is a devastating viral illness that originated in Wuhan China in late 2019 and there are nearly 2 million confirmed cases. The mortality rate is approximately 5% of reported cases and over half of patients that require mechanical ventilation for respiratory failure. As the disease continues to spread, strategies for reducing duration of ventilator support in patients with COVID-19 could significantly reduce morbidity and mortality of these individuals and future patients requiring this severely limited life-saving resource. Methods to improve gas exchange and to reduce the inflammatory response in COVID-19 are desperately needed to save lives. The ketogenic diet is a high fat, low carbohydrate, adequate-protein diet that promotes metabolic ketosis (ketone body production) through hepatic metabolism of fatty acids. High fat, low carbohydrate diets have been shown to reduce duration of ventilator support and partial pressure carbon dioxide in patients with acute respiratory failure. In addition, metabolic ketosis reduces systemic inflammation. This mechanism could be leveraged to halt the cytokine storm characteristic of COVID-19 infection. The hypothesis of this study is that the administration of a ketogenic diet will improve gas exchange, reduce inflammation, and duration of mechanical ventilation. The plan is to enroll 15 intubated patients with COVID 19 infection and administer a 4:1 ketogenic formula during their intubation.

NCT04358835 COVID-19 Dietary Supplement: Ketogenic diet Other: standard of care

Primary Outcomes

Description: PaCO2 is the partial pressure of carbon dioxide Units: millimeters of mercury

Measure: Change in the partial pressure of carbon dioxide (PaCO2)

Time: Daily until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Secondary Outcomes

Description: Minute ventilation is the product of respiratory rate and tidal volume. Units: Liter per minute

Measure: Change in minute ventilation

Time: every 6 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Respiratory system compliance measures the extent to which the lungs will expand. In a ventilated patient, compliance can be measured by dividing the delivered tidal volume by the [plateau pressure minus the total peep]. Units: liter/centimeter of water

Measure: Change in respiratory system compliance

Time: every 6 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Driving pressure is a measure of the strain applied to the respiratory system and the risk of ventilator-induced lung injuries Driving pressure = Plateau pressure - Total Positive end-expiratory pressure (PEEP) Units: centimeter of water

Measure: Change in driving pressure

Time: every 6 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Ventilator synchrony is the match between the patient's neural inspiratory time and the ventilator insufflation time

Measure: Change in ventilator synchrony

Time: every 6 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Mean arterial pressure is the average pressure in a patient's arteries during one cardiac cycle. Mean arterial pressure = diastolic blood pressure +[1/3(systolic blood pressure - diastolic blood pressure)] Units: millimeter of mercury

Measure: Change in mean arterial pressure

Time: every 6 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: FiO2: Fraction of Inspired Oxygen Percentage of oxygen in the air mixture that is delivered to the patient. Units: %

Measure: Change in the fraction of inspired oxygen percentage of oxygen (FiO2)

Time: every 6 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: PaO2/FiO2 ratio is the ratio of arterial oxygen partial pressure (PaO2) to fractional inspired oxygen. Units: millimeter of mercury

Measure: Change in the partial pressure of carbon dioxide (PaO2) to the fraction of inspired oxygen percentage of oxygen (FiO2) ratio

Time: every 6 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: pH measures hydrogen ion activity. It is a conventional part of every arterial blood gas determination pH: no units.

Measure: Change in hydrogen ion activity (pH)

Time: every 6 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Bicarbonate is a conventional part of every arterial blood gas determination Units: milliequivalents/Liter

Measure: Change in Bicarbonate (HCO3)

Time: every 6 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Red blood cell count measure anemia or hypoglycemia. Units: cells per liter

Measure: Change in red blood cell count

Time: every 6 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: White blood cell count evaluates leukopenia or leukocytosis. Units: cells/liter

Measure: Change in white blood cell count

Time: every 6 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: White cell differential shows the amount of neutrophils, lymphocytes, basophils, eosinophils and may give some clue of the type of infection. Units: %

Measure: Change in white cell differential

Time: every 6 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Hemoglobin is an indirect way to measure red blood cells. Units: gram/deciliter

Measure: Change in hemoglobin levels

Time: every 6 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Hematocrit measures the volume percentage of red blood cells in blood. Units: %

Measure: Change in hematocrit

Time: every 6 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Mean cell volume is a measure of the average volume of a red blood corpuscle. Units: femtoliters

Measure: Change in mean cell volume

Time: every 6 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Mean cell hemoglobin is the average mass of hemoglobin per red blood cell in a sample of blood. Units: picograms

Measure: Change in mean cell hemoglobin

Time: every 6 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Mean cell hemoglobin concentration is the average concentration of hemoglobin in a given volume of blood. Units: %

Measure: Change in mean cell hemoglobin concentration

Time: every 6 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Platelet count measures the number of platelets in the blood and determines thrombocytopenia or thrombocytosis. Units: platelets/liter

Measure: Change in platelet count

Time: every 6 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Red cell distribution width is a measure of the range of variation of red blood cell volume. Units: no units

Measure: Change in red cell distribution width

Time: every 6 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Liver function test Units: gram/deciliter

Measure: Change in blood albumin level

Time: every 6 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Liver function test Units: international units/liter

Measure: Change in serum alkaline phosphatase level

Time: every 6 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Liver function test Units: international units/liter

Measure: Change in serum aspartate transaminase level

Time: every 6 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Liver function test Units: international units/liters

Measure: Change in serum alanine aminotransferase level

Time: every 6 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Kidney function test Units: milligram/deciliter

Measure: Change in blood urea nitrogen levels

Time: every 6 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Kidney function test Units: milligram/deciliter

Measure: Change in serum calcium level

Time: every 6 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Kidney function test Units: millimole/liter

Measure: Change in serum chloride level

Time: every 6 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Kidney function test Units: millimole/liter

Measure: Change in serum potassium level

Time: every 6 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Kidney function test Units: gram/deciliter

Measure: Change in serum creatinine level

Time: every 6 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: If the patient needs mechanical ventilation for a second time, this information will be collected.

Measure: Date patient is re-intubated or need mechanical ventilation for a second time

Time: Up to 10 days

Description: Time from intensive care unit admission until death or transfer to hospital bed.

Measure: Length of intensive care unit stay

Time: Up to 10 days

Description: Time from hospital admission to discharge from the hospital. This information will be collected.

Measure: The total hospital stay

Time: Up to 10 days

Description: Once the patient feels better and can leave the hospital, he/she will be discharged. The place of discharge (e.g. home, rehab facility, nursing home, etc), time and date will be collected.

Measure: Disposition at discharge

Time: Up to 10 days

Description: Heart rate: is the number of times a person's heart beats per minute

Measure: Change in heart rate

Time: every 6 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Units: milligram

Measure: Change in the dosage of vasopressor medication

Time: every 6 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Other Outcomes

Description: Units: milligram/deciliter

Measure: Change in total blood cholesterol level

Time: At baseline and every 24 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Units: milligram/deciliter

Measure: Change in blood low-density lipoprotein level

Time: At baseline and every 24 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Units: milligram/deciliter

Measure: Change in blood high-density lipoprotein level

Time: At baseline and every 24 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Units: milligram/deciliter

Measure: Change in blood triglycerides level

Time: At baseline and every 24 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Glucose: sugar in blood. Units: millimole/liter

Measure: Change in blood glucose level

Time: At baseline and every 24 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Glucagon: hormone release by pancreas that increase concentration of glucose in blood. Units: nanogram/liter

Measure: Change in blood glucagon level

Time: At baseline and every 24 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Free fatty acids are fatty acids that are produced from triglycerides and are measure in blood.

Measure: Change in blood free fatty acids level

Time: At baseline and every 24 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Hormone that regulates glucose. Units: insulin units/liter

Measure: Change in blood insulin levels

Time: At baseline and every 24 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Leptin helps regulate and alter long-term food intake and energy expenditure. Units: nanogram/deciliter

Measure: Change in blood leptin levels

Time: At baseline and every 24 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Units: nanomole/liter

Measure: Change in blood insulin like growth factor 1 levels

Time: At baseline and every 24 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: C-reactive protein is a protein made by the liver that measures inflammation (e.g. pancreatitis). Units: microgram/milliliter

Measure: Change in blood C‐reactive protein levels

Time: At baseline and every 24 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Cytokines are signaling molecules that measure inflammation.

Measure: Change in blood interleukin-1β levels

Time: At baseline and every 24 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Cytokines are signaling molecules that measure inflammation.

Measure: Change in blood interleukin-6 levels

Time: At baseline and every 24 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Cytokines are signaling molecules that measure inflammation.

Measure: Change in blood interleukin-18 levels

Time: At baseline and every 24 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Cytokines are signaling molecules that measure inflammation.

Measure: Change in blood tumor necrosis factor alpha levels

Time: At baseline and every 24 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Chemokine that mediates inflammation.

Measure: Change in blood C-C motif chemokine ligand 2 (CCL2) levels

Time: At baseline and every 24 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Chemokine that mediates inflammation.

Measure: Change in blood C-C motif chemokine ligand 3 (CCL3) levels

Time: At baseline and every 24 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Chemokine that mediates inflammation.

Measure: Change in blood C-C motif chemokine ligand 4 (CCL4) levels

Time: At baseline and every 24 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Chemokine that mediates inflammation.

Measure: Change in blood B cell-attracting chemokine 1 (CXCL13) levels

Time: At baseline and every 24 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Ferritin stores iron inside of cells. Units: nanogram/milliliter

Measure: Change in blood ferritin levels

Time: At baseline and every 24 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Units: millimole/liter

Measure: Change in blood betahydroxybutyrate levels

Time: At baseline and every 24 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days

Description: Units: millimole/liter

Measure: Change in blood urine acetoacetate levels

Time: At baseline and every 24 hours until the patient is wean off the ventilator or die, whichever came first, assessed up to 10 days


No related HPO nodes (Using clinical trials)