CovidResearchTrials by Shray Alag

CovidResearchTrials Covid 19 Research using Clinical Trials (Home Page)

Normal salineWiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (2)

Name (Synonyms) Correlation
drug552 Nitric Oxide Wiki 0.71
drug46 Anakinra Wiki 0.38

Correlated MeSH Terms (6)

Name (Synonyms) Correlation
D011024 Pneumonia, Viral NIH 0.17
D055371 Acute Lung Injury NIH 0.16
D012127 Respiratory Distress Syndrome, Newborn NIH 0.15
D012128 Respiratory Distress Syndrome, Adult NIH 0.13
D045169 Severe Acute Respiratory Syndrome NIH 0.07
D018352 Coronavirus Infections NIH 0.06

Correlated HPO Terms (0)

Name (Synonyms) Correlation

There is one clinical trial.

Clinical Trials

1 Early Identification and Treatment of Cytokine Storm Syndrome in Covid-19

This proposal addresses the problem of preventing the very high mortality and morbidity associated with the development of Cytokine Storm Syndrome (CSS) associated respiratory failure in Covid-19 infection.

NCT04362111 Cytokine Storm COVID-19 Drug: Anakinra Drug: Normal saline

Primary Outcomes

Description: Supplemental oxygen requirement to maintain oxygen saturation >90% stable or decreased without escalation of respiratory measures (addition of CPAP, initiation of mechanical ventilation)

Measure: No increase in oxygen requirement and no increase in respiratory support measures

Time: 48 hours

Secondary Outcomes

Description: 25% decrease in noted baseline elevations of serum ferritin, LDH, CRP, and d-dimer.

Measure: Improvement in Cytokine Storm markers

Time: 72 hours

Description: Subjects discharged from hospital without the need for mechanical ventilation

Measure: No requirement for mechanical ventilation

Time: Day 5 (120 hours)

No related HPO nodes (Using clinical trials)