Covid 19 Research using Clinical Trials (Home Page)
PEEP trialWiki
Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation
Correlated Drug Terms (3)
| Name (Synonyms) | Correlation | |
|---|---|---|
| drug828 | Telmisartan Wiki | 0.71 |
| drug82 | Azithromycin Wiki | 0.21 |
| drug360 | Hydroxychloroquine Wiki | 0.13 |
Correlated MeSH Terms (4)
| Name (Synonyms) | Correlation | |
|---|---|---|
| D055371 | Acute Lung Injury NIH | 0.16 |
| D013577 | Syndrome NIH | 0.15 |
| D012127 | Respiratory Distress Syndrome, Newborn NIH | 0.15 |
| D012128 | Respiratory Distress Syndrome, Adult NIH | 0.13 |
Correlated HPO Terms (0)
| Name (Synonyms) | Correlation |
|---|
There is one clinical trial.
Clinical Trials
1 Evaluation of Respiratory Mechanics and Lung Recruitment in Patients With SARS-CoV-2 Associated Acute Respiratory Distress Syndrome
The aim of this observationnal study is to describe respiratory mechanics and lung recruitement in patients with SARS-CoV-2 Associated Acute Respiratory Distress Syndrome who underwent invasive ventilation on endotracheal tube, admitted to the medical ICU of Angers university hospital . Statics measurements of respiratory system compliance were performed at 2 differents levels of PEEP (15 cmH2O and 5 cmH2O). The recruited volume is computed as the difference between the volume expired from PEEP 15 to 5 cmH2O and the volume predicted by compliance at PEEP 5 cmH2O . The recruitment-to-Inflation (R/I) ratio (i.e. the ratio between the recruited lung compliance and CRS at PEEP 5 cmH2O) is used to assess lung recruitability. A R/I ratio value higher than or equal to 0.5 was used to define highly recruiter patients.
NCT04350710 Acute Respiratory Distress Syndrome COVID Other: PEEP trial MeSH:Respiratory Distress Syndrome, Newborn Respiratory Distress Syndrome, Adult Acute Lung Injury Syndrome
Primary Outcomes
Description: no unit
Measure: Recruitment-to Inflation ratio (R/I ratio) Time: Day 1Description: no unit
Measure: Recruitment-to Inflation ratio (R/I ratio) Time: Day 5Description: no unit
Measure: Recruitment-to Inflation ratio (R/I ratio) Time: Day 10Secondary Outcomes
Description: Arterial blood gases
Measure: PaO2/FiO2 (mmHg) Time: Day 1Description: Arterial blood gases
Measure: PaO2/FiO2 (mmHg) Time: Day 5Description: Arterial blood gases
Measure: PaO2/FiO2 (mmHg) Time: Day 10Description: mL
Measure: Lung volume recruited (VRec) Time: Day 1Description: mL
Measure: Lung volume recruited (VRec) Time: Day 5Description: mL
Measure: Lung volume recruited (VRec) Time: Day 10Description: Obtained by inspiratory pause of 5 seconds
Measure: Plateau pressure (cm H2O) Time: Day 1Description: Obtained by inspiratory pause of 5 seconds
Measure: Plateau pressure (cm H2O) Time: Day 5Description: Obtained by inspiratory pause of 5 seconds
Measure: Plateau pressure (cm H2O) Time: Day 10Measure: Oesophagal pressure (cm H2O) Time: Day 1
Measure: Oesophagal pressure (cm H2O) Time: Day 5
Measure: Oesophagal pressure (cm H2O) Time: Day 10
Measure: weight (Kg) Time: Day 1
Measure: weight (Kg) Time: Day 5
Measure: weight (Kg) Time: Day 10
Measure: urine output (mL) Time: day 1
Measure: urine output (mL) Time: day 5
Measure: urine output (mL) Time: day 10
Measure: serum creatinine (Umo/L) Time: day 1
Measure: serum creatinine (Umo/L) Time: day 5
Measure: serum creatinine (Umo/L) Time: day 10
Measure: Mean arterial pressure (mmHg) Time: day 1
Measure: Mean arterial pressure (mmHg) Time: day 5
Measure: Mean arterial pressure (mmHg) Time: day 10
Measure: Peak Pressure (cm H2O) Time: Day 1
Measure: Peak Pressure (cm H2O) Time: Day 5
Measure: Peak Pressure (cm H2O) Time: Day 10
Description: Obtained by expiratory pause of 5 seconds
Measure: PEEP total (cm H2O) Time: Day 1Description: Obtained by expiratory pause of 5 seconds
Measure: PEEP total (cm H2O) Time: Day 5Description: Obtained by expiratory pause of 5 seconds
Measure: PEEP total (cm H2O) Time: Day 10Measure: PEP Set (cm H2O) Time: Day 1
Measure: PEP Set (cm H2O) Time: Day 5
Measure: PEP Set (cm H2O) Time: Day 10
Measure: Height (cm) Time: Day 1
Measure: Airway pening pressure (cm H2O) Time: day 1
Measure: Airway pening pressure (cm H2O) Time: day 5
Measure: Airway pening pressure (cm H2O) Time: day 10
Description: respiratory rate decreased to 10 /min, expired tidal volume displayed by the ventilator is noted
Measure: Expired volume in PEEP setted at 15 cmH2O (mL) Time: Day 1Description: respiratory rate decreased to 10 /min, expired tidal volume displayed by the ventilator is noted
Measure: Expired volume in PEEP setted at 15 cmH2O (mL) Time: Day 5Description: respiratory rate decreased to 10 /min, expired tidal volume displayed by the ventilator is noted
Measure: Expired volume in PEEP setted at 15 cmH2O (mL) Time: Day 10Description: respiratory rate decreased to 10 /min, expired tidal volume displayed by the ventilator is noted
Measure: Expired volume in PEEP setted at 5 cmH2O (mL) Time: Day 1Description: respiratory rate decreased to 10 /min, expired tidal volume displayed by the ventilator is noted
Measure: Expired volume in PEEP setted at 5 cmH2O (mL) Time: Day 5Description: respiratory rate decreased to 10 /min, expired tidal volume displayed by the ventilator is noted
Measure: Expired volume in PEEP setted at 5 cmH2O (mL) Time: Day 10