Name (Synonyms) | Correlation | |
---|---|---|
drug610 | Phosphate buffered saline Placebo Wiki | 1.00 |
drug43 | Aluminum hydroxide adjuvant (Alhydrogel®) Wiki | 1.00 |
drug356 | Human umbilical cord derived CD362 enriched MSCs Wiki | 1.00 |
drug685 | Recombinant S protein SARS vaccine Wiki | 1.00 |
Name (Synonyms) | Correlation | |
---|---|---|
D055371 | Acute Lung Injury NIH | 0.16 |
D013577 | Syndrome NIH | 0.15 |
D012127 | Respiratory Distress Syndrome, Newborn NIH | 0.15 |
D012128 | Respiratory Distress Syndrome, Adult NIH | 0.13 |
Name (Synonyms) | Correlation |
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There is one clinical trial.
Acute Respiratory Distress Syndrome (ARDS) causes the lungs to fail due to the collection of fluid in the lungs (pulmonary oedema). ARDS is common in severely ill patients in Intensive Care Units and is associated with a high mortality and a high morbidity in those who survive. ARDS occurs in approximately 20% case of COVID-19 and respiratory failure is the leading cause of mortality. There is a large economic burden with direct healthcare costs, but also indirectly due to the impact on the carer and patient through the patients inability to return to full time employment. There is little evidence for effective drug (pharmacological) treatment for ARDS. There is increasing information that mesenchymal stem cells (MSCs) might be important in treating ARDS. REALIST will investigate if a single infusion of MSCs will help in the treatment of ARDS. The first step will be to first of all determine what dose of MSCs is safe and then divide patients suffering from ARDS into two groups, one of which will get MSCs and the other a harmless dummy (or placebo) infusion, who will then be followed up to determine if lung function improves. If effective this may lead to further research to determine if MSCs are effective in patients with ARDS.
Description: OI is a physiological index of the severity of ARDS and measures both impaired oxygenation and the amount of mechanical ventilation delivered
Measure: Oxygenation index (OI) Time: Day 7Description: Incidence of SAEs
Measure: Incidence of Serious Adverse Events (SAEs) Time: 28 daysDescription: SOFA score is a measure of organ failure
Measure: Sequential Organ Failure Assessment (SOFA) score Time: Days 4, 7 and 14Description: Crs is a physiological measure of pulmonary function in ARDS
Measure: Respiratory compliance (Crs) Time: Days 4, 7 and 14Description: P/F ratio is a physiological measure of pulmonary function in ARDS
Measure: Partial pressure of arterial oxygen to the fraction of inspired oxygen ratio (P/F ratio) Time: Days 4, 7 and 14