Name (Synonyms) | Correlation | |
---|---|---|
D009102 | Multiple Organ Failure NIH | 1.00 |
D018746 | Systemic Inflammatory Response Syndrome NIH | 0.58 |
D058186 | Acute Kidney Injury NIH | 0.45 |
D055371 | Acute Lung Injury NIH | 0.16 |
D013577 | Syndrome NIH | 0.15 |
D012127 | Respiratory Distress Syndrome, Newborn NIH | 0.15 |
D012128 | Respiratory Distress Syndrome, Adult NIH | 0.13 |
Name (Synonyms) | Correlation |
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There is one clinical trial.
Patients presenting to the emergency department, or needing hospitalization, for a variety of medical conditions often require non-invasive ventilation (breathing support). For example, for a person with shortness of breath as a complication of COPD (Chronic obstructive pulmonary disease) the gold standard of care requires application of a BiPAP machine. However, in the current environment of COVID-19, the aerosols produced by this machine in a COVID-19 positive patient pose serious potential harms to healthcare providers and other patients. All patients with similar symptoms to COVID-19 need to be treated as positive until definite testing determines otherwise. The best test available for COVID-19 takes up to 4 hours to determine the patients status, which is too long to delay application of a BiPAP. This could lead to either a delay in care or the need for invasive breathing measures (intubation), which requires intense resource utilization, may not be in line with a patient's goals of care, and could cause serious harms (i.e. infection, medication reactions, etc.) in patients who do not need it. The use of a closed-loop BiPAP machine in which no expired air is released into the environment would solve these problems. Building off the failures of a similar approach that was trialed in Italy in response to the COVID-19 crisis, this project will develop and test a novel closed-loop BiPAP system.
Description: The primary objective of this study is to assess if the mask device leaks when attached to a patient's face in real-world use. This outcome will be measured by having a researcher assess the physical seal on the patient four times throughout the device's use. The researcher will also screen the non-invasive ventilator machine for indications that the leak alarm has been triggered throughout the participant's engagement in the study. This outcome will be measured by total leak volume litres/minute.
Measure: Total Leak Volume of Non Invasive Ventilation Mask Time: Baseline to 24 hoursDescription: Metabolic data will include measuring the patients level of consciousness through the 15 point Glasgow coma scale (3-15 points, 3 points= lowest level of consciousness (no response, decompensation of patient), 15= awake, oriented, responding appropriately).
Measure: Glasgow Coma Scale(GCS) Time: Baseline to 24 hoursDescription: Respiratory status will be measured in part by the patients respiratory rate by respirations per minute. Normal respiratory rate is 12-20 respirations per minute.
Measure: Respiratory Rate Time: Baseline to 24 hoursDescription: Patient's condition will be measured by vital signs including heart rate in beats per minute. Normal heart rate is 60-100 beats per minute.
Measure: Heart Rate Time: Baseline to 24 hoursDescription: The patients pH will be measured to monitor patient condition throughout the study. Normal pH 7.35-7.45. Increasing acidosis indicative of worsening hypercapnia.
Measure: Metabolic Data: Blood Gas Measurements Time: Baseline to 24 hoursDescription: The patients HC03 level will be measured in mmol/L to monitor patients condition throughout the study.
Measure: Metabolic Data: Bicarbonate (HC03) Time: Baseline to 24 hoursDescription: The patients PaC02 level will be measured in mmHg to monitor patients condition. throughout the study. Increase in PaC02 levels indicative of worsening hypercapnia.
Measure: Metabolic Data: Partial Pressure of Carbon Dioxide (PaC02) Time: Baseline to 24 hoursDescription: The patients Pa02 level will be measured in mmHg to monitor patients condition throughout the study.
Measure: Metabolic Data: Partial Pressure of Oxygen (Pa02) Time: Baseline to 24 hours