CovidResearchTrials by Shray Alag

CovidResearchTrials Covid 19 Research using Clinical Trials (Home Page)

1: NaproxenWiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (1)

Name (Synonyms) Correlation
drug14 2: Standard of care Wiki 1.00

Correlated MeSH Terms (1)

Name (Synonyms) Correlation
D016638 Critical Illness NIH 0.26

Correlated HPO Terms (0)

Name (Synonyms) Correlation

There is one clinical trial.

Clinical Trials

1 Efficacy of Addition of Naproxen in the Treatment of Critically Ill Patients Hospitalized for COVID-19 Infection

The symptoms of respiratory distress caused by COVID-19 may be reduced by drugs combining anti-inflammatory and antiviral effects. This dual effect may simultaneously protect severely-ill patients and reduce the viral load, therefore limiting virus dissemination We want to demonstrate the superiority of naproxen (anti-inflamatory drug) treatment addition to standard of care compared to standard of care in term of 30-day mortality.

NCT04325633 COVID-19 Drug: 1: Naproxen Drug: 2: Standard of care
MeSH:Critical Illness

Primary Outcomes

Measure: Mortality all causes at day30

Time: at day30

Secondary Outcomes

Measure: Number of days alive free of mechanical ventilation

Time: during 30 days after randomization

Measure: Number of days alive outside

Time: during 30 days after randomization

Measure: Number of days alive outside hospital

Time: during 30 days after randomization

Measure: Maximal changes in Sofa score

Time: in the first 7 days after randomization

Measure: Time to negativation of virus titer in the nasopharyngeal aspirate (NPA)

Time: during 90 days after randomization

No related HPO nodes (Using clinical trials)