CovidResearchTrials by Shray Alag


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Usual care positioning with no instructionsWiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (1)


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drug435 Intermittent prone positioning instructions Wiki 1.00

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There is one clinical trial.

Clinical Trials


1 Prone Positioning in Awake Patients With COVID-19 Requiring Hospitalization

Acute respiratory distress syndrome (ARDS) is a major complication among patients with severe disease. In a report of 138 patients with COVID-19, 20% developed ARDS at a median of 8 days after the onset of symptoms, with 12.3% of patients requiring mechanical ventilation. Efficacious therapies are desperately needed. Supportive care combined with intermittent prone positioning may improve outcomes. Prone positioning (PP) of patients with severe ARDS (when combined with other lung-protective ventilation strategies) is associated with a significant mortality benefit. In addition, PP for >12 hours in severe ARDS is strongly recommended by clinical practice guidelines. The aim of this study is to compare the outcomes of prone positioning versus usual care positioning in non-intubated patients hospitalized for COVID-19.

NCT04368000 Respiratory Failure COVID-19 Behavioral: Intermittent prone positioning instructions Behavioral: Usual care positioning with no instructions
MeSH:Respiratory Insufficiency

Primary Outcomes

Measure: Change in imputed partial pressure of oxygen over fraction of inspired oxygen (PaO2/FiO2) from peripheral capillary oxygen saturation over fraction of inspired oxygen (SpO2/FiO2)

Time: 72 hours

Secondary Outcomes

Measure: Change in imputed PaO2/FiO2 from SpO2/FiO2

Time: 48 hours

Measure: Proportion of participants requiring endotracheal intubation

Time: Up to 8 weeks

Measure: Proportion of participants requiring mechanical ventilation

Time: Up to 8 weeks

Measure: Proportion of participants transferred to intensive care for worsening respiratory failure

Time: Up to 8 weeks

Measure: Proportion of participants who had escalated oxygen delivery needs

Time: Up to 8 weeks

Measure: Average number of days hospitalized

Time: Up to 8 weeks

Measure: Average number of ventilator-free days

Time: Up to 8 weeks

Measure: Proportion of participants discharged from hospital on hospice

Time: Up to 8 weeks

Measure: Proportion of participants with all-cause inpatient mortality

Time: Up to 8 weeks


No related HPO nodes (Using clinical trials)