|drug956||high flow nasal cannula (HFNC) Wiki||1.00|
|drug657||Prone positioning (PP) Wiki||1.00|
|drug776||Standard of care (SOC) Wiki||1.00|
|D055371||Acute Lung Injury NIH||0.16|
|D012127||Respiratory Distress Syndrome, Newborn NIH||0.15|
|D012128||Respiratory Distress Syndrome, Adult NIH||0.13|
|D014777||Virus Diseases NIH||0.11|
|D045169||Severe Acute Respiratory Syndrome NIH||0.07|
|D018352||Coronavirus Infections NIH||0.06|
There is one clinical trial.
No optimal antiviral intervention has been yet validated to treat COVID-19 disease. Comorbidities, such as older age, obesity, diabetes, history of cardiovascular diseases are associated with poor prognosis. This study aims to evaluate the efficacy of two experimental antiviral treatments, compared to standard of care (SOC), to prevent clinical worsening, hospitalization or death at day 14 in adults with documented SARS-CoV-2 infection, asymptomatic or with symptoms lasting less than 8 days, and associated comorbidities without any severity criteria of the disease at inclusion. Participants will be randomized to receive SOC alone or SOC + hydroxychloroquine 200 mg three times a day during 10 days or SOC + association of niclosamide 2 g at J1 then 500 mg two times a day with diltiazem 60 mg three times a day during 10 days. Efficacy and tolerance of each treatments will be compared across the three treatment groups during the 28 days of follow-up.
Description: Composite criteriaMeasure: death Time: At day 14
Description: clinical worsening defined by at least one of the NEWS score item > 2 (temperature >39,1°C or<35°C, cardiac rate >111 or ≤40 bpm, respiratory rate > 21 or ≤8 cycles par minute, SaO2 ≤ 93% room air (if its measure is available),need of oxygenMeasure: clinical worsening (composite criteria) Time: At day 14
Description: clinical state as reflected by NEWS scoring, the clinical state of the patient regarding respiratory state as defined by the NEWS scoring systemMeasure: National Early Warning Score (NEWS) Time: at day 3, day 8, day 14 day 28
Description: Number of patients deathMeasure: Mortality Time: at day 14 and at day 28