Covid 19 Research using Clinical Trials (Home Page)
Linagliptin 5 MGWiki
Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation
Correlated Drug Terms (0)
| Name (Synonyms) | Correlation |
|---|
Correlated MeSH Terms (8)
| Name (Synonyms) | Correlation | |
|---|---|---|
| D008659 | Metabolic Diseases NIH | 1.00 |
| D004700 | Endocrine System Diseases NIH | 1.00 |
| D044882 | Glucose Metabolism Disorders NIH | 1.00 |
| D003924 | Diabetes Mellitus, Type 2 NIH | 0.58 |
| D003920 | Diabetes Mellitus, NIH | 0.58 |
| D012140 | Respiratory Tract Diseases NIH | 0.38 |
| D045169 | Severe Acute Respiratory Syndrome NIH | 0.07 |
| D018352 | Coronavirus Infections NIH | 0.06 |
Correlated HPO Terms (0)
| Name (Synonyms) | Correlation |
|---|
There is one clinical trial.
Clinical Trials
1 Efficacy and Safety of Dipeptidyl Peptidase-4 Inhibitors in Diabetic Patients With Established COVID-19
The coronavirus disease 2019 (COVID-19) is an emerging pandemic in 2020 caused by a novel coronavirus named SARS-CoV2. Diabetes confers a significant additional risk for COVID-19 patients. Dipeptidyl peptidase 4 (DPP-4) is a transmembrane glycoprotein expressed ubiquitously in many tissues. In addition to its effect on glucose levels, DPP-4 has various effects on the immune system and several diseases, including lung diseases. This trial aims to assess the safety and efficacy of linagliptin, a DPP-4 inhibitor, in the treatment of COVID-19. The trial will be randomized without blinding, with one are treated by insulin only for glucose balance and the other by insulin and linagliptin. The trial will assess the effects of linagliptin on different measures of COVID-19 recovery.
NCT04371978 COVID 19 Coronavirus Diabetes Mellitus, Type 2 Diabetes Mellitus Glucose Metabolism Disorders Metabolic Disease Endocrine System Diseases Dipeptidyl-Peptidase IV Inhibitors Linagliptin Severe Acute Respiratory Syndrome Coronavirus 2 Sars-CoV2 Hypoglycemic Agents Respiratory Tract Diseases Inc Incretins Hormones Drug: Linagliptin 5 MG MeSH:Coronavirus Infections Severe Acute Respiratory Syndrome Diabetes Mellitus Diabetes Mellitus, Type 2 Metabolic Diseases Glucose Metabolism Disorders Respiratory Tract Diseases Endocrine System Diseases
HPO:Abnormality of the endocrine system Diabetes mellitus Type II diabetes mellitus
Primary Outcomes
Description: Clinical change is defined as 2 points reduction in the World Health Organization (WHO) Ordinal Scale for Clinical Improvement of COVID-19: 0 - No clinical or virological evidence of infection; 1 - No limitation of activities; 2 - Limitation of activities; 3 - Hospitalized, no oxygen therapy; 4 - Oxygen by mask or nasal prongs; 5 - Non-invasive ventilation or high-flow oxygen; 6 - Intubation and mechanical ventilation; 7 - Ventilation + additional organ support - pressors, renal replacement therapy, extracorporeal membrane oxygenation; 8 - Death.
Measure: Time to clinical change Time: 28 days
Secondary Outcomes
Measure: Percent of serious adverse events and premature discontinuation of treatment. Time: 28 days
Description: Percent of patients with a 2 points reduction in the World Health Organization (WHO) Ordinal Scale for Clinical Improvement of COVID-19.
Measure: Percent of patients with clinical improvement. Time: 28 days
Measure: Length of hospitalization. Time: 28 days
Measure: All-cause mortality. Time: 28 days
Measure: Percent of supplemental oxygen use. Time: 28 days
Measure: Supplemental oxygen-free days. Time: 28 days
Measure: Percent of mechanical ventilation use. Time: 28 days
Measure: Ventilator-free days. Time: 28 days
Measure: Percent of ICU admissions. Time: 28 days
Measure: ICU-free days. Time: 28 days
Measure: Percent of 50% decrease in C-reactive protein (CRP) levels Time: Up to 28 days
Measure: Time to virologic response, defined as no detection of SARS-CoV-2 in a PCR test. Time: 28 days
Related HPO nodes (Using clinical trials)
HP:0000818: Abnormality of the endocrine system
Genes 1858
LETM1 UBR1 FAT4 NONO CPLANE1 GLI3 BIRC3 ZSWIM6 PRKAR1A SOX9 RP1 CYP11B1 TRNS1 CYP11B2 TRNL1 NNT LHX4 INS PAX8 FSHB SDHD DUSP6 LRP4 NDUFB10 LMNA MAPK8IP1 LEPR NSMCE2 ARL6 CTDP1 RDH12 POLG ARL3 FGF8 MARS1 ENPP1 CEL TAC3 CDKN2C HSD11B2 GBA RAB23 INPP5E ARL2BP LHB PRPF31 PNPLA6 TBX1 BLK KCNJ11 ZFPM2 HIRA SLC19A2 SRD5A2 MEN1 CEP57 BBS5 KCNJ11 MCTP2 NRXN1 LMNA SDHC LHX3 BUB1B SEMA3C RETN CFTR SMPD1 SCNN1G SUFU BMPR1B EDA LHX1 HLA-DPB1 SRGAP1 WT1 ARSL GCK HAMP PSMD12 BMPR1A PAPSS2 PIK3C2A MC2R PRPF8 ENPP1 NEUROD1 SUFU RAB3GAP2 IGF2 PPP1R3A SDHC IGF2BP2 IFT27 IL12RB1 LHCGR MRPS22 TSHR NONO HERC2 CYP19A1 B4GALNT1 CYB5A GTF2I TXNRD2 SLC25A22 RPGRIP1L IARS2 DNMT3A PRPF6 ZNF408 PROP1 VPS33B IYD PEX1 PNPLA6 NPAP1 DLL1 BEST1 SLC52A3 DNAL4 SLC5A5 ND2 FANCM TBX3 BBS7 SIX3 POU1F1 TRNE CLPP AKT2 GATA6 ATAD3A CHD7 NRAS BRCA1 CYP17A1 ANOS1 GHR HRAS WT1 GATA1 KCTD1 MAK GATA3 SDHB GPC4 INPP5K MPI DCLRE1C ERCC5 NDN FAM161A HESX1 KIAA0586 SAA1 MRAP DUSP6 EDN3 OTX2 SCN4A SLC52A2 SDHD EFEMP2 MRAS GPR101 LHX4 POLR3A TGFB1 POLR3A GJA1 RNASEH2A TGFBR2 ALG1 MINPP1 APC NEK9 SASH1 SEC23B SOX10 HADHA GHSR GABRA3 GLA NDUFAF1 TCOF1 KCNJ11 GATA6 HYLS1 MGME1 VHL TBX19 PTDSS1 RAD51C THRB RMRP ATM ABCC8 VAMP7 RPL35A NFKB2 RAB3GAP1 BCL10 AXL NDUFB3 GH1 NSMF TFR2 FANCD2 GNAS GAS1 ABCC8 STAG3 KMT2D SOS1 GHR FAM20A ZMYND15 RFC2 CTRC LIPE WIPF1 PIK3CA GCK CLDN19 CSPP1 PTH1R SLC37A4 FBP1 TBC1D20 SRY TRNQ SDHD FANCI SCNN1B SPINK1 MAP3K1 RET CDON BSCL2 VANGL1 CDH23 AK2 MAD2L2 TEX11 PTPN22 COG2 SEMA3A SNRPN AHR PTH1R LHX3 HYMAI SCN2A PRKAR1A KLHL3 PEX14 GPR35 FANCA NSMCE2 HLA-DPA1 IL17RD LBR PSMC3IP SLX4 RAG2 TRNW AIP MKS1 POLA1 NR3C1 BBS2 TRNE CISD2 DNAJC21 LSS PLVAP KMT2D PPP2R3C SMC1A GHSR SRA1 BBS2 TSC1 LRP6 POLR1C PRKACA SLC25A4 FUT8 RFWD3 SCNN1A NSMCE3 ZMPSTE24 ELN ERCC6 TACR3 MLH3 NDUFV1 PRSS1 CERKL PTCH1 POLE SRY PTPN11 PLIN1 TP53 VPS13B FOXL2 CAVIN1 SDHB CFTR SMAD4 TNPO3 TWNK HNF1A AKT1 WDR4 IGF1R SNAP29 CCDC141 MCM8 AIRE WASHC5 IPW POLG2 SLC16A2 INS PLXND1 TSC2 NDUFS7 BUB1 HGSNAT SHH UCP2 FGFR1 MCM4 MSH6 APC CEP290 HABP2 SH2B1 PEX12 SPINK1 GLI2 APPL1 NSMF ZIC2 POLR3B HADH CRX KLHL7 POLR1C ALMS1 PDX1 KIAA0556 PEX5 KDM6A BBIP1 CTLA4 AVPR2 ZBTB20 GNE BRCA2 AHI1 AIRE NDUFS3 AGBL5 AKT1 TPO DHX38 CCND1 HLA-DRB1 STUB1 GPC4 INS ERCC5 TRHR ACP5 HNF1A DAXX SLC30A8 CDC73 DNAJC19 PEX16 ND1 IFT27 NANOS1 SLC16A1 OCRL ADAR PDE8B PDX1 DMPK RAB3GAP1 CYP11B1 GNRH1 BBS1 PEX2 PRLR TMEM127 GNAS NKX2-1 TCF4 GNAS SEMA4A ZBTB20 PIK3CA FRAS1 GCH1 KIZ RAB3GAP2 CASR FGFR1 APPL1 FLII NR5A1 REV3L MRPS22 PTEN SPATA7 AGPAT2 SOX2 BMPR1A USP9X FANCC WRN IL2RG CNTNAP2 TRAPPC11 RPS17 PROKR2 RIN2 PRKAR1A KIF1B NR5A1 UBE2T PHF6 PEX1 AMACR SPINK1 PTEN GYS2 CYP2R1 PEX1 EIF2S3 BCOR ND1 RECQL4 ERCC2 RAI1 MMP2 GATA4 NLRP3 KLHL10 POU2AF1 ANOS1 IQSEC2 BSCL2 POLR3B HYMAI COX2 CASR NUBPL CEP19 PROKR2 TCTN3 TRNQ TBX1 IYD RORC PRPF4 FOXE3 KCNA1 KEAP1 ERCC4 KCNJ5 CDKN2A VIPAS39 NLGN3 PDE11A NR2E3 COL7A1 TSHR GNAS ERGIC1 GLI3 PLAGL1 CDKL5 RPL15 COX3 PRCD SCNN1B FOXA2 PNPLA6 CAMKMT NDUFA11 DGCR2 SRY GNAS BMP4 H19-ICR PITX2 SDHB SLC7A7 DHDDS SLCO2A1 BCS1L BMP2 BRCA2 IFT140 RP2 STEAP3 INS NDUFS2 SYCP3 CBX2 PROK2 CNGA1 NDP MEN1 NPM1 IFIH1 TNXB KISS1R TMEM216 AIP PRPH2 APOA5 DCAF17 SRY ABCC8 FANCI FAH HSD11B1 PHKG2 MEN1 ATRX SEC24C ENTPD1 RPL31 TG IL2RG SIL1 ARMC5 AIP NRAS KIAA1549 EIF2S3 DHH MMP1 TSHR CACNA1D APC MKKS TDGF1 AKT2 RPL11 HMGA2 PEX14 TBX2 SMARCB1 CORIN FANCA ITGB6 PRDM16 LHX4 FOS BBS10 TSHR PAX8 NDUFAF3 B9D1 CYP17A1 NKX2-1 ABCC8 GNAS NUP107 ERCC2 CAV1 XRCC4 STS THOC2 FANCB LIPA ARMC9 DBH POLR3A KRAS LMNA HSD3B2 RBM28 NOTCH2 WRN INSR SEMA3E CEP41 AKT2 TBCE NDUFA6 GCM2 CACNA1S ATP7B INSR CDKN1A GNAS-AS1 GHR CASR TMEM231 TPO HPD TRNL1 NR0B1 GPR161 LEMD3 PTPN22 KAT6B NR0B1 HSD17B4 COX1 INSR SP110 PDE4D STAR TRNC SPRY4 PRKAR1A MAP3K1 AHI1 CFTR KCNQ1OT1 PRKACA TMEM237 FANCC FOXE1 IDH2 NDUFB9 RREB1 GCGR TTPA RNU4ATAC TSHR HESX1 SIN3A PLAGL1 CCDC22 ALX3 SIL1 PHKG2 RET PLAA TRIM32 ERCC1 CBX2 NLRP1 ESR2 TMEM126B SRD5A2 PHGDH PTPN11 KAT6B FLT1 ADA CDC73 CLCNKB PRTN3 PROP1 SDHA APC FMR1 APC2 RIT1 FOXI1 RCBTB1 BBS9 NDUFA1 NSD1 HACE1 PCSK1 ZFYVE26 HNF1A TACR3 ABCC8 OTX2 IFT88 GLUD1 ND4 GNAS NEK2 WASHC5 RNF216 RHO SLC25A13 MMP14 ITPR3 THRA BPTF MSMO1 SLC26A4 IRX5 SIX6 SLC19A2 HNF1B IGFALS IDH2 PEX6 CLCN5 TBX1 NEUROD1 MSH3 GTF2IRD1 RAI1 CDKN2B TRNN ND6 ANK1 POLD1 GATA3 C1QBP PDE11A NR3C2 TNFSF15 HDAC8 SPIDR POR BRAF PITX2 DMPK TRNV USB1 BMP4 SETD5 ADNP FSHR ABCC8 PIK3R1 HPGD NDUFAF4 HS6ST1 CDHR1 ZFP57 ATP6 KDM6A MAP3K7 USP8 WNT4 CYP11B2 NEUROG3 GLIS3 EIF2B1 CAVIN1 GBA SIX1 CYP27B1 ZFP57 KCNJ11 FANCE EXOSC2 FANCM SYCE1 MAX CASR MAGED2 ZNF423 HJV HESX1 HNF1B PIBF1 IRS2 SHH CYP11B2 SLC37A4 FEZF1 MOG ARNT2 CLCNKB RAC1 POLR3A TRNF NDUFB11 BRAF IFT172 EIF2B5 AMHR2 STAT3 PTPN22 AKT1 SGPL1 SDHC NSD2 MAGEL2 PDX1 TERC EXT2 AR KLF11 FANCE GDF9 PLIN1 IDH3B PRMT7 PEX5 KCNJ10 FGFR1 FOXD3 HNF1A NLGN4X CPLX1 ABCA4 DCLRE1C TRNW FAM111A NDE1 DCLRE1C RNU4ATAC FBN1 HESX1 GH1 IL7R STAR STUB1 COL4A5 NEUROD1 ZMPSTE24 RAG1 PIK3CA PSTPIP1 TSHB HNF1A GALT STAT1 SLC35A2 GDNF CYP11A1 WAS SHH SMC1A PGM1 MCOLN1 IL2RA CACNA1S HMGA1 NDUFS8 ATM RAB3GAP2 DNAJC3 ATRX EDA2R SOX3 MKRN3-AS1 AHSG CACNA1D RAD21 HABP2 H19 UBR1 IMPG2 HNF4A NAB2 MEN1 MC2R CYP27B1 LMNA GCM2 CDH23 EPCAM NR0B1 KISS1 POR POR KCTD1 WFS1 SRP54 ESR1 NR3C2 RECQL4 GNRHR ND3 DDB2 ABCC6 TSR2 PTEN NRAS HNF1A PHKA2 PAX4 SLC7A14 MC4R KCNAB2 CUL4B ARHGEF18 DUOX2 IRF5 MTNR1B ARL13B SOX3 KISS1R CP CNBP POLE ATRX TERT TSHR SAMHD1 CNGB1 PHF21A NFKB2 ATRX CYP11A1 AVPR2 IDH3A POLR3H RPL18 CLPB HNF1B PCARE TP63 SEMA3E OPA1 AGPAT2 AR LZTFL1 TTC8 TGIF1 TREX1 ANTXR2 SOHLH1 POU1F1 WDR11 C8ORF37 SALL1 CFTR GPR101 PPARG SLC25A11 XRCC4 FOXC1 PRKCD BBS4 SDHB COQ2 TCF7L2 RET PCSK1 ZMPSTE24 PNPLA6 NR5A1 DICER1 IGF1 PMM2 GCK SLC25A11 GPR101 GNAO1 NDUFAF5 ERCC4 NDUFV2 FOXE1 WFS1 PPM1B RPS7 TRNL1 NKX2-1 FSHR EYA1 LHCGR ALG8 LEP WNT4 PUF60 TRNF MSTO1 CLCN5 EP300 PDE4D KCNE3 ESS2 GLI2 PNPLA2 PNPLA6 SLC1A1 KISS1R CYTB SOX3 STRADA PEX5 HYLS1 CEP104 DUOX2 PTEN LZTR1 SCN4A ROBO1 TBX19 SNORD115-1 CDKN1C SPIB ARVCF DGCR6 MST1 TMEM237 POMGNT1 AQP2 TMEM127 TEX14 MRPS7 SDHA THRB IGF2 KCNJ10 JMJD1C MEN1 CEP41 TRNS1 ND5 MMEL1 FGF17 AVP FLI1 HSD17B4 NF1 SUFU LIFR VDR STAT3 SOX2 TTC37 LIPC INSR NRTN FOXP1 HSD11B2 SIM1 PEX2 HLA-DRB1 PMS2 PROM1 AIP GNAS INPP5E CPA1 HNF4A TCTN2 NNT DUSP6 RAD51 SLC26A4 STAT6 SCP2 SDHB MKRN3 STAT5B LRBA FSHB MEN1 POLG PEX5 TAC3 SIX3 EFL1 VHL TSHR HNF1A GNRH1 FANCD2 TMEM237 CDH23 NODAL GNAS XRCC4 ND1 MSH2 SHROOM4 GNAS POC1A MAP2K1 PEX10 DUOXA2 WHCR IDH1 KCNJ11 TSHB GJB3 PEX11B SDHD RAI1 AVP INS RPS20 USP8 GH1 ERF SRD5A3 FOXP3 CCDC141 APOA5 SCNN1G LHCGR IL6 PRKAR1A FGFR1 THRB NRL BBS10 ABCC8 BTK DGCR8 MKKS BBS5 FANCL CLCNKA TG LMNA COX3 TP53 SLC12A1 FOXE1 SDHD H6PD CDC73 PHEX WRAP53 HNF4A NKX2-5 COX2 ARX PAX8 FAS PAX4 NR5A1 SDHAF2 BBS12 LIG4 POLR1D PAX4 RRM2B FMR1 C1S BLK RPS19 NR5A1 BTNL2 GPC3 HRAS SLC34A3 ND5 PEX11B TRIM8 GDNF NKX2-1 CUL3 ENTPD1 PTEN MAFA ZFAT IL2RA GNAS ALG1 ERCC3 PPARG ERCC6 IFT172 SLC5A5 RPGR G6PC3 ACTG2 SNORD116-1 OTX2 YARS2 SETD2 SOST HJV AK2 RASA2 MYH3 HSD3B2 APC LIG4 PSMD12 POU3F4 PDE6B PUS1 PALLD HSD17B3 STOX1 RFWD3 DCC CA4 ARL3 HYMAI CYP21A2 TCTN1 TXNRD2 HADHB RAF1 NOP10 LIPA VDR RAP1A FANCM NHP2 PCNT PCK1 LEP CRB1 ALX4 TWNK SIK1 SLC25A20 POLR3B HESX1 GNRH1 PRPS1 GJB4 CCBE1 EPG5 PEX6 SOX10 SLC29A3 ADAT3 AP2S1 PEX3 RBM28 PTF1A SOX3 SUGCT HLA-DQB1 ITCH RET SBDS RPL26 WNK4 LZTFL1 PROK2 STAT1 PDE8B FGFRL1 KISS1R CASP10 CACNA1C PHGDH TRIP13 GLA B3GLCT KIAA0556 BSND RAP1B HAMP CTNNB1 PTEN TMCO1 RPS10 GCK ELN SMARCAL1 FLCN EIF2B3 MAX PALB2 PUS1 MKS1 LEPR PRPF3 SDHD GCK PDGFB HS6ST1 PNPLA2 HDAC8 ESR1 SPRY4 VPS13B POLG ANOS1 ND6 DUOXA2 CLRN1 PPARG PROKR2 STEAP3 ADA NTN1 MEIOB MECP2 TOPORS TG LMNA DLST DDX3X ATP8 UFD1 EIF2AK3 CC2D2A ECE1 RPS15A TMEM67 APOE WDPCP LMNB2 KCNJ10 SDHAF2 NF2 CASK LMNA PEX13 RPS29 CTC1 IGFALS AMH TTC8 XRCC2 CASR GCM2 MC4R GLUD1 FAS POLA1 FGF17 TP63 AAAS SDHC DCC G6PC CISD2 TTC8 DCHS1 TBC1D7 POLR3B RPE65 BMP15 BRCA1 RNASEH2B AVPR2 MRAP TFAP2A ARMC5 FLNB SLC12A3 APC PDE4D TBCE AIP KMT2A CEL NANOS1 PROP1 TP53 ALDOA ARL6 MAGEL2 KCNJ11 PWAR1 SCARB2 DIS3L2 HNF4A IRS1 CYP11A1 FOXE1 INSR TANGO2 WT1 POLR3A WNK1 ADAMTSL1 PNKP XPA TINF2 IL17RD RAG2 WFS1 FGF17 HBB NPHP1 MERTK CTNS KCNJ11 SRY LMNA SARS2 PDE6G ERCC8 GLI2 SAG AMACR XPC STX16 CDKN1B CTRC PHF6 RRM2B GATA1 TONSL DCLRE1C PDE6A MAB21L2 IER3IP1 STXBP1 TBC1D24 CTDP1 TP53 TMEM67 CYP19A1 TAF13 SLC16A2 POF1B PDX1 TYMP GREM1 IQSEC2 CDON CDKN1C DICER1 FAM111A RNPC3 PROKR2 MKRN3 GCK RASGRP1 FLRT3 DNAH1 CEP290 NSDHL SNRNP200 DHCR7 PTRH2 EYS GH1 CLCNKB WNT4 RPGRIP1L PEX19 FOXI1 SOX9 KDSR CDKN1C SOX10 RRAS2 GPC1 TSHR DISP1 CUL4B SPRY4 TBCE FANCF TDRD9 RLBP1 HFM1 KLF11 ADA2 PDX1 ALX4 GPD2 CILK1 MLXIPL HSD17B3 MDM2 CDH23 CLIP2 CTBP1 REEP6 PTCH2 TRIP4 RNF216 PDX1 FLCN INSR LIG4 PAX8 NECTIN1 SAMD9 GNRHR SDCCAG8 HS6ST1 TRAPPC9 PRSS1 CTLA4 KCNJ18 GMPPA TBL2 ALMS1 DMRT3 KRAS MINPP1 IARS2 POMC GUCA1B MKS1 FH FANCG HNF4A PEX26 PTPN1 HESX1 FXN CDC73 RPS26 GNAS NKX2-5 RPS27 COX1 BCS1L SLC29A3 GCM2 SLC26A3 GJB2 SEMA3D COMT IL17RD CDKN2A FXN SKI WWOX POLG ZSWIM6 GPC3 TRNL2 GCGR TACR3 TWNK FAM111B HFE TRNH PEX10 IDH1 NR0B1 FGFR1 HTR1A ZMPSTE24 CYP11B1 TRNK TRNL1 BBS1 CEP120 AAAS TUB CP PEX13 SLC2A2 KRAS KMT2A RAD51 PRLR NDUFS1 GABRD SMCHD1 GP1BB SKIV2L WDR11 VPS13A RP9 PDGFRB B4GALNT1 PPARG DIS3L2 NDUFS4 IGSF1 DCAF17 EDNRB TTC7A SDCCAG8 RBP3 FANCB DDOST NR5A1 GAN PAX4 SLC26A4 RTEL1 VHL NSMF TRNS1 RNF125 NPHP1 PTCH1 BRAF GK XRCC2 FOXC2 KCNJ18 HNF1B FBLN5 IMPDH1 GNA11 TRH NIPBL TAF4B RIN2 LIPE PTPN11 KCNJ1 VHL PITX2 CEP120 NDUFS6 STX16 RPL5 PEX19 BMP15 SOS2 LAS1L GJA1 NKX2-5 TEX15 PEX12 RRAS CDC73 TRNW CDKN1B AHI1 TIMMDC1 RPL35 NKX2-5 IL12A PSAT1 KIF1B DICER1 FOXRED1 DUOX2 USP9X DKC1 GLI3 IFT74 SMAD4 STK11 LMNA NIN FASLG NR5A1 CREBBP NDUFAF2 CTRC OFD1 CYP11B1 SPINK1 PRKAR1A KCNJ5 SDHC FGFR1 ANTXR1 BAZ1B KRAS PRSS2 BSCL2 INS PROK2 WFS1 MRE11 MED12 ABCC8 RGR ERCC3 ERCC2 VAX1 RERE DACT1 CHRNG MSH3 FGF8 SCAPER EIF2B2 SMCHD1 AQP2 FAN1 PIGQ ABCC8 PROP1 SMC3 CC2D2A DNAJC3 DLST ARNT2 PARN FGF17 PMM2 TRMT10A MARS2 CHEK2 PWRN1 IFNG GLRX5 MDH2 PIGP MKS1 TTC7A SLC39A4 TRNK PRSS2 CTNS PEX3 OTX2 LHX3 GMNN INSR JAG1 DEAF1 NEUROD2 PTF1A TSC1 EIF2AK3 FUCA1 KCNQ1 TMEM67 TGFB1 TRIM32 CYP11B2 ELMO2 PTCH1 PEX26 LRP5 ROM1 BUB3 RRM2B RET TBCE PLCG2 DNM1L PEX6 LRAT WFS1 TRAF3IP1 LIG4 TP53 POU1F1 ZNF148 SRY FEZF1 KISS1 PREPL WDR11 HDAC8 SETBP1 COL7A1 BBS2 FOXH1 FMR1 DMXL2 RAB18 AR HNF4A H19 KAT6B FMR1 PMS1 DHH BBS12 TMEM138 CHD7 FGF8 SNRPN CACNA1S USH2A TSC2 KCNJ11 DMRT1 C8ORF37 FLRT3 FUZ RAG1 MLH1 CYP17A1 TRNS2 LMNA TF CAV1 SDHD PEX1 EIF2B4 WDR11 SEMA4A PIEZO1 FOXP3 CIDEC CDC73 DDX3X PPP1R15B RET PCNT ABCD1 SECISBP2 TWNK A2ML1 PEX10 INPP5E GCK PTH PREPL CHD7 LHX4 COG2 ARL6IP6 NSUN2 ZNF513 TRNS2 LIPA TBX3 PRKAR1A NPHS1 POMC FEZF1 LMNA FOXE1 SIN3A LIMK1 CCDC28B RPL27 TULP1 CHD7 FDX2 RPS24 PROKR2 HFE PEX16 SLC12A3 GLI2 TBX1 FSHR CDKN1B CHD7 IGH CNOT1 FGF8 WNT3 BLM SLC26A4 MGME1 HADH RNASEH2C PIK3R1 TRNL1 KLLN SLC3A1 CD36 PEX6 ZMPSTE24 SEC23B SOX9 SEMA3E PRSS1 CCDC141 SALL1 KCNJ11 MALT1 PTEN PALB2 CHD7 BRIP1 BBS4 SOX3 SDHB LAS1L LMNA MSTO1 CEP57 TP53 TBX1 PLCD1 RPS28 FSCN2 FGD1 Protein Mutations 0
SNP 0
HP:0000819: Diabetes mellitus
Genes 523
PDE6A IDH3A UBR1 IER3IP1 SPINK1 HNF1B PCARE ND1 OPA1 RP1 AGPAT2 TRNS1 MMP2 TTC8 PDX1 TGIF1 TREX1 CDON CFTR MKRN3 GCK INS PPARG HYMAI COX2 XRCC4 SNRNP200 NUBPL PTRH2 CEP19 NDUFB10 PROKR2 EYS LMNA TRNQ MAPK8IP1 LEPR TCF7L2 NSMCE2 PRPF4 ARL6 RDH12 ARL3 FGF8 GCK KDSR CEL DISP1 NR2E3 NDUFAF5 ARL2BP ERGIC1 PLAGL1 PRPF31 PNPLA6 NDUFV2 COX3 PRCD RLBP1 WFS1 KLF11 TRNL1 PDX1 NDUFA11 BLK KCNJ11 GPD2 SLC19A2 DHDDS MLXIPL LEP CLIP2 BMP2 BRCA2 TRNF IFT140 LMNA RP2 REEP6 NDUFS2 PDX1 PDE4D LIG4 RETN CNGA1 GLI2 NDP PNPLA2 EDA CYTB LHX1 PRSS1 NPM1 IFIH1 TBL2 ALMS1 GCK PRPH2 HAMP DCAF17 ABCC8 SNORD115-1 PRPF8 ENPP1 GUCA1B MEN1 MST1 NEUROD1 POMGNT1 HNF4A PTPN1 PPP1R3A FXN AIP KIAA1549 IGF2BP2 NKX2-5 EIF2S3 COX1 SLC29A3 ND5 SUFU CDKN2A HERC2 FXN CYP19A1 STAT3 MKKS SOX2 LIPC INSR GTF2I TDGF1 GCGR HMGA2 TWNK HFE TRNH HLA-DRB1 CORIN PRPF6 ZNF408 FGFR1 PROM1 FOS ZMPSTE24 PEX1 CPA1 HNF4A NPAP1 NDUFAF3 DLL1 BEST1 TRNK TRNL1 POLG CAV1 XRCC4 ND2 TUB CP SLC2A2 KRAS EFL1 NDUFS1 HNF1A SIX3 POLR3A RP9 TRNE AKT2 NODAL PPARG XRCC4 ND1 NDUFS4 GATA6 WRN DCAF17 TTC7A AKT2 RBP3 POC1A PAX4 RTEL1 NDUFA6 TRNS1 KCNJ11 INSR GJB3 INS CASR USP8 MAK FOXC2 FOXP3 HNF1B GATA3 IMPDH1 APOA5 LIPE TRNL1 LEMD3 IL6 PRKAR1A FGFR1 NDN COX1 FAM161A HESX1 INSR NRL NDUFS6 ABCC8 TRNC CFTR GJA1 PRKACA NDUFB9 TRNW COX3 TTPA GPR101 PLAGL1 TIMMDC1 GJA1 WRAP53 RNASEH2A HNF4A COX2 PAX4 FOXRED1 PAX4 DKC1 RRM2B SMAD4 BLK TMEM126B ND5 NDUFAF1 FLT1 KCNJ11 MAFA GATA6 IL2RA CLCNKB NDUFAF2 CTRC PPARG OFD1 IFT172 SPINK1 PRKAR1A RPGR ATM SNORD116-1 OTX2 NDUFA1 ZFYVE26 NDUFB3 BAZ1B PRSS2 BSCL2 ABCC8 INS WFS1 IFT88 PDE6B GAS1 ABCC8 ABCC8 RGR PALLD ND4 STOX1 GNAS NEK2 RFC2 CA4 HYMAI CTRC LIPE RHO MMP14 SCAPER NOP10 ITPR3 GCK SLC19A2 NHP2 HNF1B CRB1 PEX6 TWNK TRNQ NEUROD1 GTF2IRD1 ABCC8 ND6 DNAJC3 POLD1 GJB4 SPINK1 PARN BSCL2 VANGL1 SLC29A3 PDE11A PTPN22 PTF1A BRAF AHR PWRN1 HYMAI TRNV GLRX5 USB1 HLA-DQB1 ITCH SBDS TRNK GPR35 PRSS2 PROK2 STAT1 NSMCE2 CTNS PIK3R1 NDUFAF4 CDHR1 ZFP57 ATP6 TRNW PTF1A CTNNB1 AIP EIF2AK3 POLA1 GCK TRNE ELN NEUROG3 CISD2 GLIS3 DNAJC21 CAVIN1 ELMO2 PTCH1 ROM1 ZFP57 BBS2 LEPR LRP6 KCNJ11 PRKACA PRPF3 SLC25A4 DNM1L GCK HJV LRAT WFS1 HNF1B TP53 PNPLA2 ELN IRS2 NDUFV1 ND6 PRSS1 CERKL CLRN1 PPARG BBS2 MOG TOPORS ARNT2 FOXH1 RAC1 HNF4A PLIN1 TP53 TRNF NDUFB11 EIF2AK3 CFTR SNRPN USH2A KCNJ11 HNF1A STAT3 C8ORF37 APOE FUZ LMNB2 IGF1R TRNS2 LMNA IPW POLG2 PDX1 TERC SLC16A2 INS CAV1 NDUFS7 AR LMNA HGSNAT KLF11 SEMA4A FOXP3 CIDEC CTC1 PLIN1 IDH3B PCNT PEX10 GCK SPINK1 APPL1 HNF1A ZIC2 ABCA4 FBN1 ZNF513 TRNS2 CRX STUB1 NEUROD1 KLHL7 CISD2 PSTPIP1 ALMS1 LMNA PDX1 LIMK1 HNF1A RPE65 BRCA1 RNASEH2B CCDC28B STAT1 AHI1 AIRE ARMC5 NDUFS3 AGBL5 PDE4D TULP1 SHH DHX38 IL2RA HMGA1 CEL NDUFS8 ATM DNAJC3 INS MAGEL2 HNF1A EDA2R HFE MKRN3-AS1 SLC12A3 SLC30A8 UBR1 ND1 IMPG2 KCNJ11 PWAR1 CNOT1 ADAR BLM PDE8B PDX1 HNF4A IRS1 RNASEH2C INSR PIK3R1 CDH23 BBS1 TCF4 ZMPSTE24 ZBTB20 KIZ TINF2 KCTD1 WFS1 SRP54 APPL1 ND3 WFS1 PRSS1 SPATA7 AGPAT2 HBB MERTK WRN KCNJ11 PALB2 HNF1A LMNA PAX4 SARS2 SLC7A14 SOX3 MC4R PDE6G LMNA ARHGEF18 SAG AMACR MTNR1B CP CNBP PLCD1 CTRC FSCN2 TERT SAMHD1 CNGB1 HP:0005978: Type II diabetes mellitus
Genes 182
SNRPN USH2A PDE6A IDH3A LIPC SNORD116-1 GTF2I GCGR C8ORF37 BAZ1B PCARE TRNH RP1 PRPF6 LMNA IPW IFT88 PDE6B ZNF408 ABCC8 RGR TTC8 PROM1 PDX1 AR ND4 NPAP1 HGSNAT NEK2 RFC2 CA4 KLF11 SEMA4A BEST1 TRNL1 RHO IDH3B MKRN3 SCAPER PPARG PCNT PEX10 TUB XRCC4 SNRNP200 SLC2A2 CEP19 CRB1 ABCA4 EYS MAPK8IP1 TRNQ TCF7L2 POLR3A RP9 GTF2IRD1 TRNE FBN1 PRPF4 AKT2 ZNF513 ARL6 TRNS2 RDH12 CRX STUB1 ARL3 NEUROD1 KLHL7 RBP3 SPINK1 NR2E3 ALMS1 TRNS1 KCNJ11 LIMK1 INSR HNF1A ARL2BP BRAF RPE65 AHR PWRN1 GLRX5 PRPF31 MAK PNPLA6 PRCD RLBP1 HNF1B AHI1 IMPDH1 TRNK AGBL5 TRNL1 TULP1 DHX38 GPD2 HMGA1 ATM NDN COX1 FAM161A NRL DHDDS CDHR1 MAGEL2 MKRN3-AS1 CLIP2 CTNNB1 AIP TRNF SLC12A3 IFT140 SLC30A8 RP2 POLA1 ND1 REEP6 IMPG2 ELN PWAR1 LIG4 RETN BLM PDX1 CNGA1 TRNW COX3 IRS1 INSR ROM1 BBS2 PRPF3 GCK KIZ TBL2 COX2 WFS1 GCK PRPH2 LRAT ABCC8 SNORD115-1 PRPF8 SPATA7 ENPP1 GUCA1B MEN1 IRS2 MERTK POMGNT1 HNF4A WRN ND6 HNF1A PTPN1 PPP1R3A CERKL CLRN1 PAX4 SLC7A14 KIAA1549 MC4R IGF2BP2 PDE6G ARHGEF18 SAG MOG AMACR TOPORS MTNR1B CLCNKB ND5 PLCD1 OFD1 FSCN2 IFT172 HERC2 CYP19A1 RPGR CNGB1
Primary Outcomes
Description: Clinical change is defined as 2 points reduction in the World Health Organization (WHO) Ordinal Scale for Clinical Improvement of COVID-19: 0 - No clinical or virological evidence of infection; 1 - No limitation of activities; 2 - Limitation of activities; 3 - Hospitalized, no oxygen therapy; 4 - Oxygen by mask or nasal prongs; 5 - Non-invasive ventilation or high-flow oxygen; 6 - Intubation and mechanical ventilation; 7 - Ventilation + additional organ support - pressors, renal replacement therapy, extracorporeal membrane oxygenation; 8 - Death.
Measure: Time to clinical change Time: 28 daysSecondary Outcomes
Measure: Percent of serious adverse events and premature discontinuation of treatment. Time: 28 daysDescription: Percent of patients with a 2 points reduction in the World Health Organization (WHO) Ordinal Scale for Clinical Improvement of COVID-19.
Measure: Percent of patients with clinical improvement. Time: 28 daysMeasure: Length of hospitalization. Time: 28 days
Measure: All-cause mortality. Time: 28 days
Measure: Percent of supplemental oxygen use. Time: 28 days
Measure: Supplemental oxygen-free days. Time: 28 days
Measure: Percent of mechanical ventilation use. Time: 28 days
Measure: Ventilator-free days. Time: 28 days
Measure: Percent of ICU admissions. Time: 28 days
Measure: ICU-free days. Time: 28 days
Measure: Percent of 50% decrease in C-reactive protein (CRP) levels Time: Up to 28 days
Measure: Time to virologic response, defined as no detection of SARS-CoV-2 in a PCR test. Time: 28 days