There are 6 clinical trials

Clinical Trials

1 Efficacy of Based MRI Contrast Media Against Covid-19

Efficacy of Sn-protoporphyrin IX (SnPPIX) and sulfonated tetranaphthyl porphyrin Against Covid-19 Mahmoud ELkazzaz(1) 1-Principal Investigator Department of chemistry and biochemistry, Faculty of Science, Damietta University, GOEIC, Egypt Mail:mahmoudramadan2051@yahoo.com Tel:00201090302015 _____________________________________________________________________________________________ _________________________________________________________________________ Abstract : The novel coronavirus pneumonia (COVID-19) is an infectious acute respiratory caused by the novel coronavirus. The virus is a positive-strand RNA virus with high homology to bat coronavirus. Depending on published study in which , conserved domain analysis, homology modeling, and molecular docking were used to compare the biological roles of specific proteins of the novel coronavirus. The principal investigator demonstrated according to previous researches that some viral structural and nonstructural proteins could bind to the porphyrin, respectively. At the same time, orf1ab, ORF10 and ORF3a proteins coordinated to attack heme on the 1-beta chain of hemoglobin, COVID-19 binds to the porphyrin of haem and displaces iron and a study denonestrated that Covid-19 could cause acquired acute porphyria which is the condition in which there is excess accumulation of porphyrin intermediate metabolites. This point can be taken advantage of X-ray induced visible luminescence of porphyrin for producing of Reactive Oxygen Species (ROS). Porphyrins have been used for photodynamic therapy (PDT) against a wide range of targets like bacteria, viruses and tumor cells It has been reported that ROS-based inactivation of viruses may occur due to several reasons, such as protein oxidation, single strand breaks in the RNA genome and protein-RNA crosslinking. Since ROS-based inactivation has a multi-targeted mechanism, it is much less likely that a virus would be able to develop resistance against it. Recently, porphyrins, already in use as photosensitizers for Photodynamic Therapy (PDT), were a study target to applications in medical area, namely as possible contrast agents in MRI. could be observed some examples of porphyrin derivatives already study as MRI contrast media. Low dark toxicity, neoplastic tissue affinity and synthetic accessibility are some of the important properties that contribute for its selection. In MRI studies was found that CM based on paramagnetic metalloporphyrins showed higher affinity for neoplastic tissues, observed by increased relaxation time of the neoplastic tissues, which is reflected on an increase in MRI signal and consequently in a better neoplastic lesions detection. Therefore, the principal investigator expects that treatment with x-ray induced visible luminescence of porphyrins will be effective in targeting of COVID-19. Keywords: COVID 2019 ,Infection, Sulfonated porphyrins and X-ray induced visible luminescence of porphyrin

NCT04371822 COVID-19 Drug: SnPP Protoporphyrin Drug: SnPP Protoporphyrin Drug: SnPP Protoporphyrin Drug: SnPP Protoporphyrin Drug: SnPP Protoporphyrin Drug: SnPP Protoporphyrin Drug: Sulfonated tetra-anthracenyl porphyrin Drug: Sulfonated tetra-anthracenyl porphyrin

2 Efficacy of Based MRI Contrast Media Against Covid-19

Efficacy of Sn-protoporphyrin IX (SnPPIX) and sulfonated tetranaphthyl porphyrin Against Covid-19 Mahmoud ELkazzaz(1) 1-Principal Investigator Department of chemistry and biochemistry, Faculty of Science, Damietta University, GOEIC, Egypt Mail:mahmoudramadan2051@yahoo.com Tel:00201090302015 _____________________________________________________________________________________________ _________________________________________________________________________ Abstract : The novel coronavirus pneumonia (COVID-19) is an infectious acute respiratory caused by the novel coronavirus. The virus is a positive-strand RNA virus with high homology to bat coronavirus. Depending on published study in which , conserved domain analysis, homology modeling, and molecular docking were used to compare the biological roles of specific proteins of the novel coronavirus. The principal investigator demonstrated according to previous researches that some viral structural and nonstructural proteins could bind to the porphyrin, respectively. At the same time, orf1ab, ORF10 and ORF3a proteins coordinated to attack heme on the 1-beta chain of hemoglobin, COVID-19 binds to the porphyrin of haem and displaces iron and a study denonestrated that Covid-19 could cause acquired acute porphyria which is the condition in which there is excess accumulation of porphyrin intermediate metabolites. This point can be taken advantage of X-ray induced visible luminescence of porphyrin for producing of Reactive Oxygen Species (ROS). Porphyrins have been used for photodynamic therapy (PDT) against a wide range of targets like bacteria, viruses and tumor cells It has been reported that ROS-based inactivation of viruses may occur due to several reasons, such as protein oxidation, single strand breaks in the RNA genome and protein-RNA crosslinking. Since ROS-based inactivation has a multi-targeted mechanism, it is much less likely that a virus would be able to develop resistance against it. Recently, porphyrins, already in use as photosensitizers for Photodynamic Therapy (PDT), were a study target to applications in medical area, namely as possible contrast agents in MRI. could be observed some examples of porphyrin derivatives already study as MRI contrast media. Low dark toxicity, neoplastic tissue affinity and synthetic accessibility are some of the important properties that contribute for its selection. In MRI studies was found that CM based on paramagnetic metalloporphyrins showed higher affinity for neoplastic tissues, observed by increased relaxation time of the neoplastic tissues, which is reflected on an increase in MRI signal and consequently in a better neoplastic lesions detection. Therefore, the principal investigator expects that treatment with x-ray induced visible luminescence of porphyrins will be effective in targeting of COVID-19. Keywords: COVID 2019 ,Infection, Sulfonated porphyrins and X-ray induced visible luminescence of porphyrin

NCT04371822 COVID-19 Drug: SnPP Protoporphyrin Drug: SnPP Protoporphyrin Drug: SnPP Protoporphyrin Drug: SnPP Protoporphyrin Drug: SnPP Protoporphyrin Drug: SnPP Protoporphyrin Drug: Sulfonated tetra-anthracenyl porphyrin Drug: Sulfonated tetra-anthracenyl porphyrin

3 Efficacy of Based MRI Contrast Media Against Covid-19

Efficacy of Sn-protoporphyrin IX (SnPPIX) and sulfonated tetranaphthyl porphyrin Against Covid-19 Mahmoud ELkazzaz(1) 1-Principal Investigator Department of chemistry and biochemistry, Faculty of Science, Damietta University, GOEIC, Egypt Mail:mahmoudramadan2051@yahoo.com Tel:00201090302015 _____________________________________________________________________________________________ _________________________________________________________________________ Abstract : The novel coronavirus pneumonia (COVID-19) is an infectious acute respiratory caused by the novel coronavirus. The virus is a positive-strand RNA virus with high homology to bat coronavirus. Depending on published study in which , conserved domain analysis, homology modeling, and molecular docking were used to compare the biological roles of specific proteins of the novel coronavirus. The principal investigator demonstrated according to previous researches that some viral structural and nonstructural proteins could bind to the porphyrin, respectively. At the same time, orf1ab, ORF10 and ORF3a proteins coordinated to attack heme on the 1-beta chain of hemoglobin, COVID-19 binds to the porphyrin of haem and displaces iron and a study denonestrated that Covid-19 could cause acquired acute porphyria which is the condition in which there is excess accumulation of porphyrin intermediate metabolites. This point can be taken advantage of X-ray induced visible luminescence of porphyrin for producing of Reactive Oxygen Species (ROS). Porphyrins have been used for photodynamic therapy (PDT) against a wide range of targets like bacteria, viruses and tumor cells It has been reported that ROS-based inactivation of viruses may occur due to several reasons, such as protein oxidation, single strand breaks in the RNA genome and protein-RNA crosslinking. Since ROS-based inactivation has a multi-targeted mechanism, it is much less likely that a virus would be able to develop resistance against it. Recently, porphyrins, already in use as photosensitizers for Photodynamic Therapy (PDT), were a study target to applications in medical area, namely as possible contrast agents in MRI. could be observed some examples of porphyrin derivatives already study as MRI contrast media. Low dark toxicity, neoplastic tissue affinity and synthetic accessibility are some of the important properties that contribute for its selection. In MRI studies was found that CM based on paramagnetic metalloporphyrins showed higher affinity for neoplastic tissues, observed by increased relaxation time of the neoplastic tissues, which is reflected on an increase in MRI signal and consequently in a better neoplastic lesions detection. Therefore, the principal investigator expects that treatment with x-ray induced visible luminescence of porphyrins will be effective in targeting of COVID-19. Keywords: COVID 2019 ,Infection, Sulfonated porphyrins and X-ray induced visible luminescence of porphyrin

NCT04371822 COVID-19 Drug: SnPP Protoporphyrin Drug: SnPP Protoporphyrin Drug: SnPP Protoporphyrin Drug: SnPP Protoporphyrin Drug: SnPP Protoporphyrin Drug: SnPP Protoporphyrin Drug: Sulfonated tetra-anthracenyl porphyrin Drug: Sulfonated tetra-anthracenyl porphyrin

4 Efficacy of Based MRI Contrast Media Against Covid-19

Efficacy of Sn-protoporphyrin IX (SnPPIX) and sulfonated tetranaphthyl porphyrin Against Covid-19 Mahmoud ELkazzaz(1) 1-Principal Investigator Department of chemistry and biochemistry, Faculty of Science, Damietta University, GOEIC, Egypt Mail:mahmoudramadan2051@yahoo.com Tel:00201090302015 _____________________________________________________________________________________________ _________________________________________________________________________ Abstract : The novel coronavirus pneumonia (COVID-19) is an infectious acute respiratory caused by the novel coronavirus. The virus is a positive-strand RNA virus with high homology to bat coronavirus. Depending on published study in which , conserved domain analysis, homology modeling, and molecular docking were used to compare the biological roles of specific proteins of the novel coronavirus. The principal investigator demonstrated according to previous researches that some viral structural and nonstructural proteins could bind to the porphyrin, respectively. At the same time, orf1ab, ORF10 and ORF3a proteins coordinated to attack heme on the 1-beta chain of hemoglobin, COVID-19 binds to the porphyrin of haem and displaces iron and a study denonestrated that Covid-19 could cause acquired acute porphyria which is the condition in which there is excess accumulation of porphyrin intermediate metabolites. This point can be taken advantage of X-ray induced visible luminescence of porphyrin for producing of Reactive Oxygen Species (ROS). Porphyrins have been used for photodynamic therapy (PDT) against a wide range of targets like bacteria, viruses and tumor cells It has been reported that ROS-based inactivation of viruses may occur due to several reasons, such as protein oxidation, single strand breaks in the RNA genome and protein-RNA crosslinking. Since ROS-based inactivation has a multi-targeted mechanism, it is much less likely that a virus would be able to develop resistance against it. Recently, porphyrins, already in use as photosensitizers for Photodynamic Therapy (PDT), were a study target to applications in medical area, namely as possible contrast agents in MRI. could be observed some examples of porphyrin derivatives already study as MRI contrast media. Low dark toxicity, neoplastic tissue affinity and synthetic accessibility are some of the important properties that contribute for its selection. In MRI studies was found that CM based on paramagnetic metalloporphyrins showed higher affinity for neoplastic tissues, observed by increased relaxation time of the neoplastic tissues, which is reflected on an increase in MRI signal and consequently in a better neoplastic lesions detection. Therefore, the principal investigator expects that treatment with x-ray induced visible luminescence of porphyrins will be effective in targeting of COVID-19. Keywords: COVID 2019 ,Infection, Sulfonated porphyrins and X-ray induced visible luminescence of porphyrin

NCT04371822 COVID-19 Drug: SnPP Protoporphyrin Drug: SnPP Protoporphyrin Drug: SnPP Protoporphyrin Drug: SnPP Protoporphyrin Drug: SnPP Protoporphyrin Drug: SnPP Protoporphyrin Drug: Sulfonated tetra-anthracenyl porphyrin Drug: Sulfonated tetra-anthracenyl porphyrin

5 Efficacy of Based MRI Contrast Media Against Covid-19

Efficacy of Sn-protoporphyrin IX (SnPPIX) and sulfonated tetranaphthyl porphyrin Against Covid-19 Mahmoud ELkazzaz(1) 1-Principal Investigator Department of chemistry and biochemistry, Faculty of Science, Damietta University, GOEIC, Egypt Mail:mahmoudramadan2051@yahoo.com Tel:00201090302015 _____________________________________________________________________________________________ _________________________________________________________________________ Abstract : The novel coronavirus pneumonia (COVID-19) is an infectious acute respiratory caused by the novel coronavirus. The virus is a positive-strand RNA virus with high homology to bat coronavirus. Depending on published study in which , conserved domain analysis, homology modeling, and molecular docking were used to compare the biological roles of specific proteins of the novel coronavirus. The principal investigator demonstrated according to previous researches that some viral structural and nonstructural proteins could bind to the porphyrin, respectively. At the same time, orf1ab, ORF10 and ORF3a proteins coordinated to attack heme on the 1-beta chain of hemoglobin, COVID-19 binds to the porphyrin of haem and displaces iron and a study denonestrated that Covid-19 could cause acquired acute porphyria which is the condition in which there is excess accumulation of porphyrin intermediate metabolites. This point can be taken advantage of X-ray induced visible luminescence of porphyrin for producing of Reactive Oxygen Species (ROS). Porphyrins have been used for photodynamic therapy (PDT) against a wide range of targets like bacteria, viruses and tumor cells It has been reported that ROS-based inactivation of viruses may occur due to several reasons, such as protein oxidation, single strand breaks in the RNA genome and protein-RNA crosslinking. Since ROS-based inactivation has a multi-targeted mechanism, it is much less likely that a virus would be able to develop resistance against it. Recently, porphyrins, already in use as photosensitizers for Photodynamic Therapy (PDT), were a study target to applications in medical area, namely as possible contrast agents in MRI. could be observed some examples of porphyrin derivatives already study as MRI contrast media. Low dark toxicity, neoplastic tissue affinity and synthetic accessibility are some of the important properties that contribute for its selection. In MRI studies was found that CM based on paramagnetic metalloporphyrins showed higher affinity for neoplastic tissues, observed by increased relaxation time of the neoplastic tissues, which is reflected on an increase in MRI signal and consequently in a better neoplastic lesions detection. Therefore, the principal investigator expects that treatment with x-ray induced visible luminescence of porphyrins will be effective in targeting of COVID-19. Keywords: COVID 2019 ,Infection, Sulfonated porphyrins and X-ray induced visible luminescence of porphyrin

NCT04371822 COVID-19 Drug: SnPP Protoporphyrin Drug: SnPP Protoporphyrin Drug: SnPP Protoporphyrin Drug: SnPP Protoporphyrin Drug: SnPP Protoporphyrin Drug: SnPP Protoporphyrin Drug: Sulfonated tetra-anthracenyl porphyrin Drug: Sulfonated tetra-anthracenyl porphyrin

6 Efficacy of Based MRI Contrast Media Against Covid-19

Efficacy of Sn-protoporphyrin IX (SnPPIX) and sulfonated tetranaphthyl porphyrin Against Covid-19 Mahmoud ELkazzaz(1) 1-Principal Investigator Department of chemistry and biochemistry, Faculty of Science, Damietta University, GOEIC, Egypt Mail:mahmoudramadan2051@yahoo.com Tel:00201090302015 _____________________________________________________________________________________________ _________________________________________________________________________ Abstract : The novel coronavirus pneumonia (COVID-19) is an infectious acute respiratory caused by the novel coronavirus. The virus is a positive-strand RNA virus with high homology to bat coronavirus. Depending on published study in which , conserved domain analysis, homology modeling, and molecular docking were used to compare the biological roles of specific proteins of the novel coronavirus. The principal investigator demonstrated according to previous researches that some viral structural and nonstructural proteins could bind to the porphyrin, respectively. At the same time, orf1ab, ORF10 and ORF3a proteins coordinated to attack heme on the 1-beta chain of hemoglobin, COVID-19 binds to the porphyrin of haem and displaces iron and a study denonestrated that Covid-19 could cause acquired acute porphyria which is the condition in which there is excess accumulation of porphyrin intermediate metabolites. This point can be taken advantage of X-ray induced visible luminescence of porphyrin for producing of Reactive Oxygen Species (ROS). Porphyrins have been used for photodynamic therapy (PDT) against a wide range of targets like bacteria, viruses and tumor cells It has been reported that ROS-based inactivation of viruses may occur due to several reasons, such as protein oxidation, single strand breaks in the RNA genome and protein-RNA crosslinking. Since ROS-based inactivation has a multi-targeted mechanism, it is much less likely that a virus would be able to develop resistance against it. Recently, porphyrins, already in use as photosensitizers for Photodynamic Therapy (PDT), were a study target to applications in medical area, namely as possible contrast agents in MRI. could be observed some examples of porphyrin derivatives already study as MRI contrast media. Low dark toxicity, neoplastic tissue affinity and synthetic accessibility are some of the important properties that contribute for its selection. In MRI studies was found that CM based on paramagnetic metalloporphyrins showed higher affinity for neoplastic tissues, observed by increased relaxation time of the neoplastic tissues, which is reflected on an increase in MRI signal and consequently in a better neoplastic lesions detection. Therefore, the principal investigator expects that treatment with x-ray induced visible luminescence of porphyrins will be effective in targeting of COVID-19. Keywords: COVID 2019 ,Infection, Sulfonated porphyrins and X-ray induced visible luminescence of porphyrin

NCT04371822 COVID-19 Drug: SnPP Protoporphyrin Drug: SnPP Protoporphyrin Drug: SnPP Protoporphyrin Drug: SnPP Protoporphyrin Drug: SnPP Protoporphyrin Drug: SnPP Protoporphyrin Drug: Sulfonated tetra-anthracenyl porphyrin Drug: Sulfonated tetra-anthracenyl porphyrin

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