CovidResearchTrials by Shray Alag


CovidResearchTrials Covid 19 Research using Clinical Trials (Home Page)


1: Prone positioningWiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (2)


Name (Synonyms) Correlation
drug821 Tele-medicine platform Wiki 1.00
drug12 2: No instruction regarding positioning Wiki 1.00

Correlated MeSH Terms (9)


Name (Synonyms) Correlation
D054143 Heart Failure, Systolic NIH 1.00
D000787 Angina Pectoris NIH 1.00
D006333 Heart Failure NIH 1.00
D003327 Coronary Disease NIH 1.00
D054058 Acute Coronary Syndrome NIH 0.71
D003324 Coronary Artery Disease NIH 0.71
D009203 Myocardial Ischemia NIH 0.58
D002318 Cardiovascular Diseases NIH 0.30
D013577 Syndrome NIH 0.15

Correlated HPO Terms (0)


Name (Synonyms) Correlation

There is one clinical trial.

Clinical Trials


1 PROne Positioning in coVID-19 Oxygeno-dependent Patients in Spontaneous Ventilation (PROVID Study)

The COVID epidemics is responsible for a huge number of death following COVID acute respiratory failure. First instance treatment includes oxygenotherapy up to 15L/min in spontaneous ventilation. However COVID infection can ultimately lead to an acute respiratory distress syndrome (ARDS) requiring mechanical ventilation in the intensive care unit (ICU). Guidelines on ARDS management are based on small ventilation volume (6 mL/kg), a pulmonary end expiratory pressure (PEEP) chosen to get the best pulmonary compliance, a plateau pressure lower than 30 cm of water and daily prone positioning when PaO2/FiO2 ratio is lower than 150. In ventilated ARDS patients, prone positioning has shown survival improvement. Though they applied this optimized management of ARDS patients, Chinese intensivists have recently reported mortality rate higher than 50% in ARDS COVID patients requiring intubation and mechanical ventilation. Before being intubated and admitted to ICU, COVID patients require increasing rate of oxygen delivery. From the start of the epidemics, we have observed that an oxygenotherapy rate higher than 3L/min at the initial phase of the disease was associated with a high risk of severe acute respiratory distress (30%) The investigators hypothesize that prone positioning in patients in spontaneous ventilation (not tubed) from the stage of oxygenotherapy higher than 3L/min (to get an SpO2 of 95% or higher) would prevent respiratory worsening and the need for intubation. Prone positioning is easy to apply in patients in spontaneous ventilation since they can change position by themselves.

NCT04366856 COVID ARDS Behavioral: 1: Prone positioning Behavioral: 2: No instruction regarding positioning

Primary Outcomes

Measure: Proportion of patients who meet one or both following criteria: need for intubation (for mechanical ventilation), occurrence of death during hospital stay.

Time: At day28

Secondary Outcomes

Measure: Proportion of patients admitted to ICU (for patients included out of ICU)

Time: At day28

Measure: Days alive and free from non invasive ventilation (NIV) or high flow nasal canula oxygen delivery (HFNC) (for those neither under NIV or HFNC at the time of study inclusion)

Time: At day28

Measure: Days alive and out of ICU

Time: At day28

Measure: Days alive and out of hospital

Time: At day28

Measure: Maximum oxygenotherapy rate during hospital stay [Time Frame: At day28]

Time: At day28


No related HPO nodes (Using clinical trials)