Name (Synonyms) | Correlation | |
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drug632 | Placebos Wiki | 0.19 |
drug360 | Hydroxychloroquine Wiki | 0.09 |
Name (Synonyms) | Correlation | |
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D001008 | Anxiety Disorders NIH | 0.35 |
D003141 | Communicable Diseases NIH | 0.08 |
D018352 | Coronavirus Infections NIH | 0.08 |
D014777 | Virus Diseases NIH | 0.08 |
D007239 | Infection NIH | 0.06 |
D045169 | Severe Acute Respiratory Syndrome NIH | 0.05 |
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There are 2 clinical trials
Blood samples from participants who have recovered from COVID-19 infection will be obtained and studied. The goal of the research is to identify antibodies that have been generated by the patient to fight the COVID-19 infection. By identifying the most effective antibodies, scientists can make specific antibodies to use to prevent future coronavirus outbreaks or to treat patients with severe disease.
Description: The blood specimen will be proceeded into peripheral blood mononuclear cells and plasma to be stored for testing. In brief, CD27+ memory B cells that can bind to a SARS-CoV-2 S protein bait will be sorted by flow cytometry and RNA will be extracted to obtain heavy and light chain sequences. Antibody sequences will be annotated using bioinformatics approaches, and candidate sequences will be cloned. Purified antibodies will be characterized and neutralization breadth and potency against SARS-CoV-2 and other related coronaviruses will be assessed using neutralization assays.
Measure: Number of antibodies against coronaviruses isolated and identified from patient samples Time: Up to 12 months after collection visitTo better understand the immune response to SARS-CoV-2 infection, we devised a precision immunology approach to systematically study the immune function of different patient cohorts
Description: Immune response of whole blood stimulation assay with various immune activators will be measured by FACS and multiplex Assay
Measure: Immune response Time: 4 weeks