Name (Synonyms) | Correlation | |
---|---|---|
drug472 | Lopinavir / ritonavir tablets combined with Xiyanping injection Wiki | 1.00 |
drug479 | Lopinavir/ritonavir treatment Wiki | 1.00 |
drug616 | Placebo Wiki | 0.10 |
There is one clinical trial.
This is a double-blinded, two-arm, randomized, placebo controlled study comparing the virological efficacy of add-on sirolimus with standard care to placebo and standard care. Virological efficacy is defined as the change from baseline to day 7 in SARS-CoV-2 viral burden measured by quantitative real-time polymerase chain reaction.
Description: SARS-CoV-2 viral burden will be quantified for both arms using a qRT-PCR
Measure: Change in SARS-CoV-2 viral burden from baseline to day 7 of treatment Time: Baseline, and days 1, 2, 3, 4, 5, 6, & 7 post-dose for all patientsDescription: SARS-CoV-2 viral burden will be quantified for both arms using a qRT-PCR
Measure: Change in SARS-CoV-2 viral burden at days 1-6 Time: Days 1, 2, 3, 4, 5, and 6 post-dose for all patientsDescription: Safety and tolerability of sirolimus in patients with COVID-19
Measure: Rate of treatment emergent adverse events Time: Days 1, 2, 3, 4, 5, and 6 post-dose for all patients