Correlated Drug Terms (0)

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	Name (Synonyms)	Correlation

Correlated MeSH Terms (1)

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	Name (Synonyms)	Correlation
D007239	Infection NIH	0.08

Correlated HPO Terms (0)

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	Name (Synonyms)	Correlation

Primary Outcomes

Description: An 8 point ordinal scale will be used to assess pulmonary status consisting of the following values: 8= Death; 7= Ventilation in addition to extracorporeal membrane oxygen (ECMO), continuous renal replacement therapy (CRRT), or need for vasopressors (dopamine ≥5 μg/kg/min OR epinephrine ≥0.1 μg/kg/min OR norepinephrine ≥0.1 μg/kg/min); 6= Intubation and mechanical ventilation; 5= Non-invasive mechanical ventilation (NIV) or high-flow oxygen; 4= Oxygen by mask or nasal prongs; 3= Hospitalization without oxygen supplementation; 2= Discharged from hospital either to home with supplemental oxygen OR to inpatient rehabilitation/skilled nursing facility (+/- supplemental oxygen); 1= Discharged to home without supplemental oxygen

Measure: Change in pulmonary status

Time: baseline, through study completion, an average of 45 days

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Secondary Outcomes

Measure: Change in ferritin levels

Time: baseline, through study completion, an average of 45 days

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Measure: Change in C-reactive protein levels

Time: baseline, through study completion, an average of 45 days

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Measure: Change in d-dimer levels

Time: baseline, through study completion, an average of 45 days

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Measure: Change in white blood cell count

Time: baseline, through study completion, an average of 45 days

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Description: number of events

Measure: Incidence of serious adverse events

Time: baseline, through study completion, an average of 45 days

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Measure: Overall survival

Time: Days 15, 30 and 60

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Description: When calculating days of hospitalization, re-hospitalization or death occurring in the first 28 days should result in zero ascribed to time out of the hospital prior to readmission.

Measure: Length of hospitalization

Time: From date of enrollment until the date of extubation, assessed study completion, an average of 45 days

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Measure: Duration of ventilation

Time: From date of enrollment until the date of extubation, assessed study completion, an average of 45 days

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Description: Reintubations or death within 28 days will result in zero ascribed time off ventilator prior to reintubation

Measure: Ventilator free days

Time: baseline, through study completion, an average of 45 days

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Measure: Improvement in arterial oxygen partial pressure (PaO2) to fractional inspired oxygen (FiO2)

Time: baseline, through study completion, an average of 45 days

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