CovidResearchTrials by Shray Alag


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Automated oxygen administration - FreeO2Wiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (1)


Name (Synonyms) Correlation
drug768 Standard administration of oxygen flow Wiki 1.00

Correlated MeSH Terms (1)


Name (Synonyms) Correlation
D011014 Pneumonia NIH 0.08

Correlated HPO Terms (0)


Name (Synonyms) Correlation

There is one clinical trial.

Clinical Trials


1 Automated Oxygen Titration - Monitoring and Weaning in Patients With Infectious Pneumonia Requiring Oxygen - Impact on the Number of Interventions for Healthcare Workers. An Innovative Device to Manage Patients With COVID-19 Pneumonia COVID Study (Closed-Loop Oxygen to Verify That Healthcare Workers Interventions Decreaseduring Pneumonia)

There is a high risk of transmission of COVID-19 to healthcare workers. In a recent cohort, 29% of the patients hospitalized were healthcare workers. Among the WHO's primary strategic objectives for the response to COVID-19, the first was to limit human-to-human transmission, including reducing secondary infections among close contacts and health care workers. Automated oxygen titration, weaning and monitoring (FreeO2 device) may be a solution to reduce the number of interventions of healthcare workers related to oxygen therapy, to reduce complications related to oxygen and to improve monitoring.

NCT04320056 Coronavirus Pneumonia Oxygen Toxicity Other: Standard administration of oxygen flow Device: Automated oxygen administration - FreeO2
MeSH:Pneumonia
HPO:Pneumonia

Primary Outcomes

Description: The number of interventions required by healthcare workers to manage oxygen therapy (titration, weaning and monitoring) during 4 hours

Measure: The number of interventions

Time: Hour0 to Hour4

Description: The number of interventions required by healthcare workers to manage oxygen therapy (titration, weaning and monitoring) during 4 hours

Measure: Duration of interventions

Time: Hour0 to Hour24

Secondary Outcomes

Description: The Mean oxygen flow during study duration to evaluate oxygen consumption

Measure: Mean oxygen flow

Time: Hour0 to Hour24 (1 day)

Description: Time within SpO2 between 90 and 94%

Measure: Time within theSpO2 target

Time: Hour0 to Hour24 (1 day)

Description: Time within SpO2 < 88%

Measure: Time with hypoxemia

Time: Hour0 to Hour24 (1 day)

Description: Time within SpO2 > 96%

Measure: Time with hyperoxemia

Time: Hour0 to Hour24 (1 day)

Description: Rate of ICU admission

Measure: Rate of ICU admission

Time: Hour0 to Hour24 (1 day)

Description: Rate of needed non invasive respiratory support Non invasive ventilation or High Flow Nasal Therapy

Measure: Rate of needed non invasive respiratory support

Time: Hour0 to Hour24 (1 day)

Description: Rate of intubation

Measure: Rate of intubation

Time: Hour0 to Hour24 (1 day)

Description: Evaluation of NEWS 2 score evolution (National Early Warning score) correlate to patient evolution. The NEWS2 score will be calculate but no intervention will be made based on this score. Patient evolution will be compare at NEWS 2 interpretation. Interpretation A low score (NEWS 1-4) should prompt assessment by a competent registered nurse who should decide if a change to frequency of clinical monitoring or an escalation of clinical care is required. A medium score (ie NEWS of 5-6 or a RED score) should consider whether escalation of care to a team with critical-care skills is required (ie critical care outreach team). A high score (NEWS ≥7) should prompt emergency assessment by a clinical team/critical care outreach team with critical-care competencies and usually transfer of the patient to a higher dependency care area.

Measure: NEWS 2 score evolution

Time: Hour0 to Hour24 (1 day)

Description: Evaluation of EWSO2 score(Early Warning ScoreO2) evolution correlate to patient evolution The EWSO2 score will be calculate but no intervention will be made based on this score. Patient evolution will be compare at EWSO2 interpretation. Interpretation Favorable clinical outcome in patients with a score <5.3 A patient with a score >18.6 will experience a poor outcome.

Measure: EWSO2 score evolution

Time: Hour0 to Hour24 (1 day)

Description: Cost effectiveness ratio (cost per SpO2 unit)

Measure: Cost-effectiveness

Time: From date of randomization until the date of hospital discharge

Description: Duration of the hospital length of stay

Measure: length of stay

Time: up to 90 days. Hospital stay - hospital admission through hospital discharge or until death if occured


Related HPO nodes (Using clinical trials)