Name (Synonyms) | Correlation | |
---|---|---|
drug395 | Hydroxychloroquine plus standard preventive measures Wiki | 1.00 |
drug627 | Placebo oral tablet Wiki | 0.22 |
drug360 | Hydroxychloroquine Wiki | 0.13 |
Name (Synonyms) | Correlation | |
---|---|---|
D045169 | Severe Acute Respiratory Syndrome NIH | 0.07 |
D018352 | Coronavirus Infections NIH | 0.06 |
Name (Synonyms) | Correlation |
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There is one clinical trial.
This COVID-19 pandemic warrants urgent strategies to protect people at high risk of infection, particularly the healthcare workers. Secondary prevention through post-exposure prophylaxis (PEP) and early treatment of infection are needed to prevent severe cases and cut secondary transmission. Hydroxycholoroquine (HCQ) is an inexpensive anti-malarial drug with immunomodulatory effects that are currently used as an off-label treatment for symptomatic COVID-19 patients. In vitro studies have shown that it can efficiently inhibit SARS-CoV-2 infection and has potential as a post-exposure prophylaxis drug.
Description: Incidence of COVID-19 infection confirmed by RT-PCR COVID-19 test within the PEP treatment period (28 days) with or without symptoms of COVID-19 infection
Measure: Efficacy of HCQ Prophylaxis in Preventing COVID-19 infection Time: 30 daysDescription: Incidence of patient self-reported COVID-19 related symptoms anytime during follow up period as measured by a standardized patient diary
Measure: Efficacy of study drug as post-exposure prophylaxis in preventing COVID-19 related symptoms (to be reported as absolute number and frequency of events) Time: 30 daysDescription: Interval from exposure to COVID-19 case Interval from first dose of study drug
Measure: Time to COVID-19 infection in patients receiving study drug (in days) Time: 30 daysDescription: Incidence of study drug discontinuation Incidence of all adverse events based on patients a) self-report using daily symptom diary and b) study physicians
Measure: Safety and tolerability of study drug (to be reported as absolute number and frequency of events) Time: 30 days