Developed by Shray Alag, The Harker School
Sections: Correlations,
Clinical Trials, and HPO
Navigate: Clinical Trials and HPO
| Name (Synonyms) | Correlation |
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Navigate: Correlations HPO
There is one clinical trial.
Several studies have suggested a potential clinical benefit of controlling hyper inflammation triggered by SARS-CoV-2/COVID-19. Blood purification, the removal of excessive proinflammatory mediators may control disease progression and support clinical recovery. For this purpose, COVID-19 patients might benefit from treatment with AN69ST hemofilter based extracorporeal blood purification.
Description: Systemic levels of IL-6, IL-8 and TNF-α are evaluated to assess the effect of blood purification. Measurement points: at admission, "before and after a blood purification cycle" and before discharge
Measure: Changes in cytokine levels of Interleukin (IL) 6, IL-8 and Tumor Necrosis Factor-α (pg/mL) Time: Hospitalisation window, day 0 until day 14 or until hospital discharge (whichever comes first)Description: Systemic levels of proinflammatory mediators are measured as a marker for disease severity. Measurement points: at admission, "before and after a blood purification cycle" and before discharge.
Measure: Changes in inflammatory markers; C-Reactive Protein (CRP) (mg/L) Time: Hospitalisation window, day 0 until day 14 or until hospital discharge (whichever comes first)Description: Systemic levels of thrombocytes are measured as a marker for disease severity. Measurement points: at admission, "before and after a blood purification cycle" and before discharge.
Measure: Changes in thrombocyte counts (10^3 counts/microL) Time: Hospitalisation window, day 0 until day 14 or until hospital discharge (whichever comes first)Description: Coagulation markers will be followed to assess the effect of systemic heparinisation, Measurement points, at admission, "before and after a blood purification cycle" and before discharge
Measure: Changes in the coagulation marker Fibrinogen (g/L) Time: Hospitalisation window, day 0 until day 14 or until hospital discharge (whichever comes first)Description: Duration of intensive care will be determined in relation to the number of blood purification cycles Patients will be followed for the duration of ICU stay.
Measure: ICU length of stay after admission (days) Time: An expected average of 4 - 14 hospitalisation days or until hospital discharge (whichever comes first)Description: Systemic levels of proinflammatory mediators are measured as a marker for disease severity. Measurement points: at admission, "before and after a blood purification cycle" and before discharge.
Measure: Changes in Neutrophil-to-Lymphocyte Ratio Time: Hospitalisation window, day 0 until day 14 or until hospital discharge (whichever comes first)Description: Coagulation markers will be followed to assess the effect of systemic heparinisation, Measurement points, at admission, "before and after a blood purification cycle" and before discharge
Measure: Changes in the coagulation marker D-Dimers (ng/mL) Time: Hospitalisation window, day 0 until day 14 or until hospital discharge (whichever comes first)Description: Coagulation markers will be followed to assess the effect of systemic heparinisation, Measurement points, at admission, "before and after a blood purification cycle" and before discharge
Measure: Changes in the Activation Clotting Time (seconds). Time: Hospitalisation window, day 0 until day 14 or until hospital discharge (whichever comes first)Alphabetical listing of all HPO terms. Navigate: Correlations Clinical Trials
Data processed on September 26, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.
Drug Reports MeSH Reports HPO Reports