Developed by Shray Alag, The Harker School
Sections: Correlations,
Clinical Trials, and HPO
Navigate: Clinical Trials and HPO
Navigate: Correlations HPO
There is one clinical trial.
The 2020 pandemic of the coronavirus (SARS-CoV2) has lead to an increase in ARDS cases requiring invasive mechanical ventilation in the ICU (Intensive Care Unit). The investigators hypothesize that airway pressure release ventilation (APRV) could be beneficial in patients with ARDS secondary to SARS-COV2 viral pneumonia.
Description: Increase of at least 20% of the PaO2/FiO2 ratio
Measure: Proportion of patients improving PaO2/FiO2 ratio at 6 hours of APRV Time: 6 hours after starting APRVDescription: Number of interventions by the physician on APRV settings
Measure: Number of interventions on ventilator settings Time: 6 hours after starting APRVDescription: Variations of blood pressure in millimeters of mercury
Measure: Change in mean blood pressure Time: 6 hours after starting APRVDescription: Variations of heart rate in beats per minute
Measure: Change in heart rate Time: 6 hours after starting APRVDescription: Variations of catecholamine doses in milligrams per hours
Measure: Changes in catecholamine doses Time: 6 hours after starting APRVDescription: Static compliance (Cstat) defined as : Cstat = (VT/(Pplat-PEPtot)) Tidal Volume (VT), Plateau pressure (Pplat) and Total Positive End-expiratory Pressure (PEEPtot)
Measure: Changes in static compliance at the end of 6 hours of APRV Time: 6 hours after starting APRVDescription: Minute ventilation in liters per minute
Measure: Variations of minute ventilation Time: 6 hours after starting APRVDescription: Static compliance (Cstat) defined as : Cstat = (VT/(Pplat-PEPtot)) Tidal Volume (VT), Plateau pressure (Pplat) and Total Positive End-expiratory Pressure (PEEPtot)
Measure: Changes in static compliance 4 hours after stopping APRV Time: 4 hours after starting APRVDescription: Percentage of patients with a decrease of the PaO2/FiO2 ratio
Measure: Proportion of patients with a decrease of the PaO2/FiO2 ratio Time: 4 hours after stopping APRVAlphabetical listing of all HPO terms. Navigate: Correlations Clinical Trials
Data processed on September 26, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.
Drug Reports MeSH Reports HPO Reports