Developed by Shray Alag, The Harker School
Sections: Correlations,
Clinical Trials, and HPO
Navigate: Clinical Trials and HPO
| Name (Synonyms) | Correlation |
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Navigate: Correlations HPO
There is one clinical trial.
Acute and chronic inflammatory eye diseases are difficult to diagnose and maintain quiescent with therapy. Proposed study is aimed to find on the one hand, novel factors for recurrence of the disease or remission of inflammation and evaluation of the impact of lifestyle and known factors on the other. Each patient is treated in accordance to the best of medical knowledge and guidelines for each disease. This prospective cohort study will enroll uveitic patients to the steroid only group (SG), combined (steroid and adjuvant drug) group (CG) or bilogic therapy group (BTG). At baseline, patient data are recorded using patient-reported outcome measures and clinical assessments (ophthalomology) on disease activity (clinical scales), quality of life, and lifestyle together with registry data on comorbidity and medication. During follow-up evaluation of a successful treatment outcome response will be based on clinical scales and most frequently used primary endpoints; the major outcome of the analyses will be to detect differences in treatment outcome between patients in different treatment group.
Description: Total number of treatment success in each group
Measure: Treatment success Time: 1 yearDescription: Time to the next recurrence after the treatment regimen introduction
Measure: Recurrence time Time: 10 yearsDescription: Time and cause of severe visual loss
Measure: Severe visual loss Time: 10 yearsDescription: Visual Acuity will be performed with ETDRS charts different for right and left eye
Measure: ETDRS Visual Acuity Time: 10 yearsDescription: At each visit anterior chamber will be examined to assess anterior chamber cells (1mm x 1mm slit beam in height and width, when thrown at an angle of 45-60°). The recorded number of cells will be used to determine the grade according to the SUN criteria.
Measure: The SUN working group grading system for anterior chamber cells Time: 10 yearsDescription: At each visit anterior chamber will be examined to assess anterior chamber flare (1mm x 1mm slit beam in height and width, when thrown at an angle of 45-60°). The observed changes will be used to determine the grade according to the SUN criteria.
Measure: The SUN working group grading system for anterior chamber flare Time: 10 yearsDescription: Using AREDS system for classifying cataracts from photographs: AREDS Report No. 4 the lens opacity will be graded.
Measure: AREDS 2008 Clinical Lens Opacity Grading Procedure Time: 10 yearsDescription: At each visit vitreous will be examined to assess vitreous cells (1mm x 3mm slit beam in anterior vitreous). The recorded number of cells will be used to determine the grade according to the NIH criteria.
Measure: NIH grading system for vitreous cells Time: 10 yearsDescription: At each visit vitreous will be examined to assess vitreous haze. The recorded of clarity of posterior pole funduscopy will be used to determine the grade according to the NIH criteria.
Measure: NIH grading system for vitreous haze Time: 10 yearsDescription: OCT EDI recordings processed with developed by researchers methodology for image processing.
Measure: Submacular choroidal thickness Time: 10 yearsDescription: PCR-positive result of COVID-19 specific testing, no treatment required
Measure: COVID-19 confirmed infection asymptomatic patient Time: 1 yearDescription: PCR-positive result of COVID-19 specific testing, patient require treatment. The mode of treatment will be recorded into several groups: 1) antibiotics, 2) antivirals, 3) biologic treatment, 4) immunoglobulins, 5) steroids
Measure: COVID-19 confirmed infection Time: 1 yearDescription: COVID-19 related acute respiratory distress syndrome (ARDS). Situation in which patients need any of described below: 1) supportive oxygen therapy, 2) non-invasive ventilation, 3) invasive/ mechanical ventilation, 4) use of ECMO, 5) admission to intensive care unit, 6) dialysis
Measure: COVID-19 related acute respiratory distress syndrome (ARDS) Time: 1 yearAlphabetical listing of all HPO terms. Navigate: Correlations Clinical Trials
Data processed on September 26, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.
Drug Reports MeSH Reports HPO Reports