|D045169||Severe Acute Respiratory Syndrome NIH||0.04|
|D018352||Coronavirus Infections NIH||0.04|
There is one clinical trial.
This study will evaluate the efficacy and safety of Hydrogen-Oxygen Generator with Nebulizer (model AMS-H-03) developed by Shanghai Asclepius Meditech Co., Ltd. as an adjuvant therapy for the patients with COVID-19 infected pneumonia in improving the clinical symptoms and reducing the incidence of severe pneumonia, as compared with the reference device of EverFlo Oxygen Concentrator (registration certificate No.: NMPA Registration Standard: 20162542389) manufactured by Respironics, Inc. US.
Description: The time from the patient's admission to the Disease Progression to critical type，up to 2 weeks.Measure: Recovery time Time: The day from the patient's admission to the Disease Progression to critical type，up to 2 weeks.
Description: Clinical Symptom Remission was defined as: The patient's body temperature was normal for more than 72 hours (without taking antipyretics or hormones) and had no conscious dyspnea or decreased dyspnea.Measure: Clinical Symptom Remission time Time: The day from admission to clinical remission,up to 2 weeks.
Description: fever duration is the time during the patient's body temperature was abnormal。Measure: fever duration Time: The day from the patient's body temperature was abnormal to normal,up to 2 weeks.
Description: The scale consisted of 19 questions in three domains: physical, psychological and social, each with a score ranging from 1.7. Each item represented an adverse event caused by a cough. The answer was scored on a Likert 7 point scale. The higher the score, the better the health condition. The total score ranged from 7 to 21.Measure: Leicester cough questionaire (LCQ) Time: The day from admission to clinical remission,up to 2 weeks.
Description: The minimum oxygen absorption flow with 95% oxygen saturation.Measure: minimum oxygen Time: The day from admission to clinical remission,up to 2 weeks.
Description: Negative conversion rate of novel coronavirus nucleic acid in respiratory tract specimens 14 days after enrollment.Measure: Negative conversion rate Time: the first day to the 14th days.
Description: White blood cell (WBC) is a colorless, spherical and nucleated blood cell. The total number of normal adults is (4.0-10.0) x 109 / L, which can be changed in a certain range due to different time of day and the functional state of the body.Measure: white blood cell(WBC) Time: The day of admission and clinical remission,up to 2 weeks.
Description: also known as red blood cells, are often abbreviated into RBC in Chinese and English in routine tests. They are the most numerous blood cells in the blood, and also the most important medium for transporting oxygen through the blood in vertebrates. At the same time, they also have immune functions.Measure: Red blood cells(RBC) Time: The day of admission and clinical remission,up to 2 weeks.
Description: The abbreviation of hemoglobin is HGB or Hb. Hemoglobin is a special protein that transports oxygen in red blood cells. It makes the blood red. It is composed of globin and heme. Its globin part is a tetramer composed of two different pairs of globin chains (α chain and β chain).Measure: Hemoglobin(Hb ) Time: The day of admission and clinical remission,up to 2 weeks.
Description: Platelets are small pieces of cytoplasm released from the cytoplasm of mature megakaryocytes in bone marrow. Although megakaryocytes are the least in the hematopoietic cells of bone marrow, accounting for only 0.05% of the total number of bone marrow nucleated cells, the platelets produced by megakaryocytes are very important for the hemostatic function of the body.Measure: Platelets(PLT) Time: The day of admission and clinical remission,up to 2 weeks.
Description: Lymphocyte count refers to count and calculate the percentage of different types of white blood cells.Measure: Lymphocyte count Time: The day of admission and clinical remission,up to 2 weeks.
Description: Lymphocyte has the function of producing and carrying antibody and preventing virus infection. The percentage of lymphocyte was determined by routine blood test, and the normal value was 20.0% - 40.0%. The percentage of lymphocyte increased mainly in infectious diseases and decreased mainly in immune deficiency diseases.Measure: The percentage of lymphocyte Time: The day of admission and clinical remission,up to 2 weeks.
Description: The membrane of neutrophils can release an unsaturated fatty acid, arachidonic acid. Under the action of enzyme, arachidonic acid can further generate a group of paracrine hormone substances, such as thromboxane and prostaglandin, which play an obvious role in regulating the caliber and permeability of blood vessels, can also cause inflammation and pain, and affect blood coagulation.Measure: neutrophils Time: The day of admission and clinical remission,up to 2 weeks.
Description: C-reactive protein (CRP) is a kind of protein (acute protein) which rises sharply in the plasma when the body is infected or damaged by tissue. It can activate the complement and strengthen the phagocytosis of phagocytes, so as to play a role in regulating. It can clear away the pathogenic microorganism and the damaged, necrotic and apoptotic tissue cells.Measure: C-reactive protein (CRP) Time: The day of admission and clinical remission,up to 2 weeks.
Description: Myocardial enzyme is a general term for many enzymes existing in the heart, including aspartate aminotransferase (AST), lactate dehydrogenase (LD or LDH), creatine kinase (CK) and isoenzyme, a-hydroxybutyrate dehydrogenase (a-hbd), etc. during acute myocardial infarction, a variety of enzymes in the heart are released due to the necrosis of myocardial cells, so the determination of serum central muscle enzyme is useful for the diagnosis and evaluation of myocardial infarction There is a certain value in the effect of suppositionMeasure: Myocardial enzyme Time: The day of admission and clinical remission,up to 2 weeks.
Description: The purpose of liver function examination is to detect the liver disease, the degree of liver damage, the cause of liver disease, the prognosis and the cause of jaundice. At present, there are many kinds of clinical trials of liver function, no less than dozens. But each kind of liver function test can only detect a certain function of a certain aspect of the liver, so far, there is still no one test that can reflect all the functions of the liver.Measure: liver function Time: The day of admission and clinical remission,up to 2 weeks.
Description: Renal function refers to the function of the kidney to excrete the body's metabolic waste, maintain the stability of electrolytes such as sodium, potassium, calcium and acid-base balance. Renal function examination includes blood creatinine, blood urea nitrogen, blood and urine β 2-microglobulin, urinary albumin, urinary immunoglobulin G, urinary secretory immunoglobulin A, etc.Measure: Renal function Time: The day of admission and clinical remission,up to 2 weeks.
Description: Muscle enzyme generally refers to: phosphocreatine kinase and creatine kinase isoenzyme examination, and some glutamic oxaloacetate transaminase. It is mainly used to check common muscle diseases.Measure: Muscle enzyme Time: The day of admission and clinical remission,up to 2 weeks.
Data processed on September 26, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.Drug Reports MeSH Reports HPO Reports