Developed by Shray Alag, The Harker School
Sections: Correlations,
Clinical Trials, and HPO
Navigate: Clinical Trials and HPO
Navigate: Correlations HPO
There is one clinical trial.
Data on respiratory mechanics and gas exchange in acute respiratory failure in COVID-19 patients is limited. Knowledge of respiratory mechanics and gas exchange in COVID-19 can lead to different selection of mechanical ventilation strategy, reduce ventilator-associated lung injury and improve outcomes. The objective of the study is to evaluate the respiratory mechanics, lung recruitability and gas exchange in COVID-19 -associated acute respiratory failure during the whole course of mechanical ventilation - invasive or non-invasive.
Description: Positive end-expiratory pressure (PEEP) selection at minimum level with maximum static compliance and the highest peripheral capillary oxygen saturation over fraction of inspired oxygen (SpO2/FiO2)
Measure: Optimum positive end-expiratory pressure (PEEP) level Time: On day 1 during mechanical ventilationDescription: Positive end-expiratory pressure (PEEP) selection at minimum level with maximum static compliance and the highest peripheral capillary oxygen saturation over fraction of inspired oxygen (SpO2/FiO2)
Measure: Optimum positive end-expiratory pressure (PEEP) level Time: On day 7 during mechanical ventilationDescription: Peripheral capillary oxygen saturation (SpO2) change from 90% after recruitment maneuver (doubled tidal volume for 15 respiratory cycles) - if peripheral capillary oxygen saturation (SpO2) after recruitment maneuver more than 95%-recruitable
Measure: Number of patients with recruitable lung Time: On day 1 during mechanical ventilationDescription: Peripheral capillary oxygen saturation (SpO2) change from 90% after recruitment maneuver (doubled tidal volume for 15 respiratory cycles) - if peripheral capillary oxygen saturation (SpO2) after recruitment maneuver more than 95%-recruitable
Measure: Number of patients with recruitable lung Time: On day 7 during mechanical ventilationDescription: Calculation of the alveolar dead space using end-tidal carbon dioxide measurement and arterial carbon dioxide tension measurement
Measure: Change in alveolar dead space Time: On day 1, 3, 5, 7, 10, 14, 21 during mechanical ventilationDescription: Measurement of plethysmogram variability before and during recruitment maneuver
Measure: Change in plethysmogram variability during recruitment maneuver Time: On day 1, 3, 5, 7, 10, 14, 21 during mechanical ventilationDescription: Calculation of the arterial partial oxygen tension to inspiratory oxygen fraction (PaO2/FiO2) ratio using arterial oxygen tension measurement
Measure: Change in arterial partial oxygen tension to inspiratory oxygen fraction (PaO2/FiO2) ratio Time: On day 1, 3, 5, 7, 10, 14, 21 during mechanical ventilationDescription: Positive end-expiratory pressure (PEEP) selection at minimum level with maximum static compliance and the highest peripheral capillary oxygen saturation over fraction of inspired oxygen (SpO2/FiO2)
Measure: Optimum positive end-expiratory pressure (PEEP) level Time: On day 3, 5, 10, 14, 21 during mechanical ventilationDescription: Driving pressure calculation at different positive end-expiratory pressure (PEEP) levels (8, 10, 12, 14)
Measure: Change in driving pressure with different positive end-expiratory pressure (PEEP) levels Time: On day 1, 3, 5, 7, 10, 14, 21 during mechanical ventilationAlphabetical listing of all HPO terms. Navigate: Correlations Clinical Trials
Data processed on September 26, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.
Drug Reports MeSH Reports HPO Reports