Developed by Shray Alag, The Harker School
Sections: Correlations,
Clinical Trials, and HPO
Navigate: Clinical Trials and HPO
| Name (Synonyms) | Correlation | |
|---|---|---|
| drug4453 | data record Wiki | 1.00 |
| drug2981 | Placebo oral tablet Wiki | 0.18 |
| Name (Synonyms) | Correlation | |
|---|---|---|
| D003550 | Cystic Fibrosis NIH | 0.33 |
| D005355 | Fibrosis NIH | 0.24 |
| Name (Synonyms) | Correlation |
|---|
Navigate: Correlations HPO
There is one clinical trial.
People with Cystic Fibrosis (CF) have problems digesting their food properly. More than 8 in 10 people with CF must take medication to assist their digestion. In spite of this, complications such as bowel blockage occur. Finding out how already licenced drugs for CF work in the gut is the first step in repurposing medications. Tezacaftor/Ivacaftor with Ivacaftor is a drug combination which corrects the basic defect in CF an has shown improvements on lung function. The purpose of this study is to evaluate, using Magnetic Resonance Imaging (MRI) and patient-reported outcomes, whether Tezacaftor/Ivacaftor with Ivacaftor has an effect on improving gastrointestinal problems in CF.
Description: Time taken after eating for ingested food to be identifiable at the caecum on MRI
Measure: Oro-caecal Transit Time Time: 1 day of scanningDescription: Volume of stomach at each time point of digestion to measure gastric emptying time
Measure: Gastric volume Time: 1 day of scanningDescription: Volume of water content in small bowel representing secretions and post prandial change in small bowel water content at T240 and T300
Measure: Small bowel water content (corrected for body surface area) Time: 1 day of scanningDescription: Volume of colon representing ease of chyme passage through colon
Measure: Colonic volume (corrected for body surface area) Time: 1 day of scanningDescription: Gastrointestinal symptoms measured by patient reported outcomes to monitor relationships with outcomes measure by MRI
Measure: Gastrointestinal symptoms Time: 1 day of scanningDescription: Volume of sigmoid colon
Measure: Sigmoid colon volume Time: 1 day of scanningDescription: An approximate measure of water content in chyme present in the ascending colon
Measure: T1 relaxation of ascending colon chyme Time: 1 day of scanningDescription: A measure of fat content in chyme present in the ascending colon
Measure: Fat fraction of ascending colon chyme Time: 1 day of scanningDescription: A measure of elastase in stool to evaluate pancreatic function
Measure: Faecal elastase Time: 1 dayDescription: A measure of microbiome in sputum and stool
Measure: Sputum and faecal microbiome Time: 1 dayDescription: A measure of intestinal inflammation
Measure: Faecal calprotectin Time: 1 dayDescription: A measure of motility at the terminal ileum using the GIQuant tool in arbitrary units
Measure: Terminal Ileum motility Time: 1 dayAlphabetical listing of all HPO terms. Navigate: Correlations Clinical Trials
Data processed on September 26, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.
Drug Reports MeSH Reports HPO Reports