Developed by Shray Alag, The Harker School
Sections: Correlations,
Clinical Trials, and HPO
Navigate: Clinical Trials and HPO
| Name (Synonyms) | Correlation |
|---|
| Name (Synonyms) | Correlation | |
|---|---|---|
| D008107 | Liver Diseases NIH | 0.33 |
| D003920 | Diabetes Mellitus, NIH | 0.17 |
| Name (Synonyms) | Correlation | |
|---|---|---|
| HP:0001392 | Abnormality of the liver HPO | 0.33 |
| HP:0000819 | Diabetes mellitus HPO | 0.17 |
Navigate: Correlations HPO
There is one clinical trial.
This is a two-arm, open-label, randomized, phase 2, controlled center study to assess the safety and efficacy of Viusid and Asbrip in patients with mild to moderate symptoms of respiratory disease caused by 2019 coronavirus infection. Patients will be randomized to receive daily doses of 30 ml of Viusid and 10 ml of Asbrip every 8 hours or standard care. Viusid and Asbrip will be administered orally. A total of 60 subjects will be randomized 2: 1 in this study. 40 patients will be assigned to Viusid plus Asbrip plus standard of care and 20 control patients with standard of care. Treatment duration: 21 days.
Description: The number of days required to achieve a score of 0 for each symptom category. Resolution of symptoms: fever (time frame: 21 days) Fever based on a 0-3 scale: 0 = ≤98.6, 1 => 98.6- 100.6, 2 => 100.6 - 102.6, 3 => 102.6 Resolution of symptoms: cough (time frame: 21 days) Cough based on a 0-3 scale: 0 = no cough, 1 = mild, 2 = moderate, 3 = severe Resolution of symptoms: shortness of breath (time frame: 21 days) Shortness of breath based on a 0-3 scale: 0 = no shortness of breath, 1 = with moderate intensity exercise 2 = walking on a flat surface 3 = shortness of breath when dressing or doing daily activities Resolution of symptoms: fatigue (period: 21 days) Fatigue based on a 0-3 scale: 1 = mild fatigue, 2 = moderate fatigue, 3 = severe fatigue. Composite score that includes all symptoms: (time frame: 21 days) Total composite score of symptoms on days 5, 10, 15, and 21 of study supplementation.
Measure: Symptom resolution Time: 21 daysDescription: Disease severity will be measured using a disease severity clinical event scale (assessed until day 21) Change from baseline in the patient's health status on an ordinal scale of 7 categories (time frame: days 3, 7, 14, 21) death Hospitalized, with invasive mechanical ventilation or extracorporeal membrane oxygenation (ECMO) Hospitalized, with non-invasive ventilation or high-flow oxygen devices Hospitalized, requiring supplemental oxygen Hospitalized, which does not require supplemental oxygen Not hospitalized, limitation of activities. Not hospitalized, without limitations in activities. Note: lower scores mean a worse result.
Measure: Cumulative incidence of disease severity Time: 21 daysDescription: Differences in the number of patients who received complementary medications for diagnosis between the study arms.
Measure: Complementary drugs required Time: 21 daysDescription: Differences in the number of patients in the study groups experiencing side effects of the supplements.
Measure: Side effects of supplementation Time: 21 daysDescription: PCR analysis at day 0, 7th, 14th and 21th to measure and compare viral load
Measure: Duration of SARS-CoV-2 PCR positivity Time: 21 daysDescription: Blood biochemical analysis at day 0, 3rd, 7th, 14th and 21th
Measure: Concentration of reactive protein c in peripheral blood Time: 21 daysDescription: Number of Incidence of hospitalization
Measure: Incidence of hospitalization Time: 21 daysDescription: Number of days of hospitalization
Measure: Duration (days) of hospitalization Time: 21 daysDescription: Number of Incidences of mechanical ventilation supply per patient
Measure: Incidence of mechanical ventilation supply Time: 21 daysDescription: Number of days with mechanical ventilation supply
Measure: Duration (days) of mechanical ventilation supply Time: 21 daysDescription: Number of incidences of oxygen use
Measure: Incidence of oxygen use Time: 21 daysDescription: Number of days of oxygen use per patient
Measure: Duration (days) of oxygen use Time: 21 daysDescription: Number of death per group
Measure: Mortality rate Time: 21 daysDescription: Number of days patient need to recover from disease
Measure: Time to return to normal activity Time: 21 daysDescription: Change from baseline in serum cytokine IL-1 level by blood biochemical analysis at day 0, 3, 7, 14 and 21
Measure: Change from baseline in serum cytokine levels Time: 21 daysDescription: Change from baseline in serum cytokine IL-6 level by blood biochemical analysis at day 0, 3, 7, 14 and 21
Measure: Change from baseline in serum cytokine levels Time: 21 daysDescription: Change from baseline in serum cytokine TNF-α level by blood biochemical analysis at day 0, 3, 7, 14 and 21
Measure: Change from baseline in serum cytokine levels Time: 21 daysDescription: Change from baseline in CCR5 receptor occupancy levels for Tregs and macrophages by blood biochemical analysis at day 0, 3, 7, 14 and 21
Measure: Change from baseline in CCR5 receptor occupancy levels for Tregs and macrophages Time: 21 daysDescription: Change from baseline in CD3 +, CD4 + and CD8 + T cell counts by blood biochemical analysis at day 0, 3, 7, 14 and 21.
Measure: Change from baseline in CD3 +, CD4 + and CD8 + T cell counts Time: 21 daysDescription: Change in liver function test (AST, ALT and TBIL) by blood biochemical analysis at day 0, 4, 7, 14 and 21.
Measure: Change in liver function test Time: 21 daysDescription: Change in kidney function with eGFR rate by blood and urinary biochemical analysis at day 0, 4, 7, 14 and 21.
Measure: Change in kidney function test Time: 21 daysDescription: Change in kidney function with creatine clearance rate by blood and urinary biochemical analysis at day 0, 4, 7, 14 and 21.
Measure: Change in kidney function test Time: 21 daysDescription: Change in routine blood test red blood cells concentration by blood biochemical analysis at day 0, 4, 7, 14 and 21.
Measure: Change in routine blood test Time: 21 daysDescription: Change in routine blood test white blood cell concentration by blood biochemical analysis at day 0, 4, 7, 14 and 21.
Measure: Change in routine blood test Time: 21 daysDescription: Change in routine blood test D-dimer level by blood biochemical analysis at day 0, 4, 7, 14 and 21.
Measure: Change in routine blood test Time: 21 daysDescription: Change in routine blood test fibrinogen level by blood biochemical analysis at day 0, 4, 7, 14 and 21.
Measure: Change in routine blood test Time: 21 daysDescription: Change in myocardial enzyme CPK-MB by blood biochemical analysis at daty 0, 4, 7, 14 and 21
Measure: Change in myocardial enzymes Time: 21 daysDescription: Change in myocardial enzymes troponins by blood biochemical analysis at daty 0, 4, 7, 14 and 21
Measure: Change in myocardial enzymes Time: 21 daysAlphabetical listing of all HPO terms. Navigate: Correlations Clinical Trials
Data processed on September 26, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.
Drug Reports MeSH Reports HPO Reports