Developed by Shray Alag, The Harker School
Sections: Correlations,
Clinical Trials, and HPO
Navigate: Clinical Trials and HPO
| Name (Synonyms) | Correlation | |
|---|---|---|
| drug3132 | Psychiatric counseling Wiki | 0.71 |
| drug65 | 40ml blood sample Wiki | 0.71 |
| drug3728 | Standard of Care Wiki | 0.11 |
Navigate: Correlations HPO
There are 2 clinical trials
This will be a phase 1a randomized, open label, multi-center study with approximately 24 subjects. All subjects will receive standard of care (SOC) per institutional guidelines for treatment of hospitalized patients with COVID-19 infection. In addition to SOC, the brequinar group will receive 5 daily doses of brequinar 100 mg.
Description: Adverse events are new onset medical conditions.
Measure: Safety/tolerability measured by rates of post randomization adverse events and hematology/chemistry safety labs. Time: Beginning at signing consent through Day 15.Description: In-patient hospitalization, hospitalized in ICU-level care, or discharged
Measure: Hospitalization status Time: Through Day 15Description: Duration in days from admission to discharge
Measure: Duration of hospitalization Time: Through Day 15Description: National Early Warning Score (NEWS) 2. Composite score of respiration rate, oxygen saturation, systolic blood pressure, pulse, consciousness, and temperature.
Measure: NEWS2 Score Time: Through Day 15Description: Subject mortality status
Measure: Mortality Time: Day 29Description: Nasopharyngeal viral load by RT-PCR at days 1, 3, 5, 7, and 15
Measure: SARS-CoV-2 nasopharyngeal viral load Time: Through Day 15Description: Pro-inflammatory cytokines including TNFalpha, INFgamma, IL13, IL12p70, IL10, IL8, IL6, IL4 IL2, IL1-beta and erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), D-dimer, serum ferritin, and fibrinogen
Measure: Inflammatory markers Time: Through Day 15Description: Plasma concentration of dihydroorotate
Measure: DHO Concentration Time: Through Day 15Description: Plasma concentration of brequinar
Measure: Brequinar Concentration Time: Through Day 15This study will assess the efficacy and safety of DHODHi (brequinar) as an antiviral via 5 days of treatment of participants with positive COVID-19 and at least one symptom of COVI019 in an out-patient setting. The study is multi-center, randomized, and placebo-controlled.
Description: Quantitative SARS-CoV-2 viral load
Measure: SARS-CoV-2 viral load Time: Day 29Description: Safety measured by rates of AEs and SAEs including laboratory assessments
Measure: Rates of AEs and SAEs including laboratory assessments Time: Day 29Description: Duration of viral shedding
Measure: Viral shedding duration Time: Day 29Description: Percentage of subjects requiring admission as an inpatient for >24 hours
Measure: Hospital Admission Time: Day 29Alphabetical listing of all HPO terms. Navigate: Correlations Clinical Trials
Data processed on September 26, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.
Drug Reports MeSH Reports HPO Reports