Developed by Shray Alag, The Harker School
Sections: Correlations,
Clinical Trials, and HPO
Navigate: Clinical Trials and HPO
| Name (Synonyms) | Correlation | |
|---|---|---|
| drug1441 | Exercise and Cognitive Training Wiki | 1.00 |
| Name (Synonyms) | Correlation | |
|---|---|---|
| D005356 | Fibromyalgia NIH | 0.45 |
| D010003 | Osteoarthritis, NIH | 0.41 |
| D008173 | Lung Diseases, Obstructive NIH | 0.27 |
| Name (Synonyms) | Correlation | |
|---|---|---|
| HP:0002758 | Osteoarthritis HPO | 0.41 |
| HP:0006536 | Pulmonary obstruction HPO | 0.27 |
| HP:0006510 | Chronic pulmonary obstruction HPO | 0.26 |
| Name (Synonyms) | Correlation | |
|---|---|---|
| HP:0000822 | Hypertension HPO | 0.20 |
Navigate: Correlations HPO
There is one clinical trial.
The overarching aim of this project is to implement and evaluate a proven cognitive training regimen in combination with a community exercise program among older adults who attend wellness exercise programs at the YMCA. To support this aim, the investigators have developed a collaboration with the YMCA of Kitchener-Waterloo, which offer exercise programs targeted to older adults. The specific objectives are: (1) to evaluate the feasibility of a combined exercise and cognitive training in a community-setting among older adults; and (2) to conduct a preliminary evaluation and comparison of changes in cognitive function, physical function, well-being and self-efficacy with 12-weeks of combined exercise and cognitive training versus exercise alone. The hypothesis for each objective are as follows: (1) It is anticipated that this program will be feasible to implement and will be well accepted by the participants and exercise providers. (2) The investigators may not have the power to find statistically significant differences between the control and experimental groups for physical and cognitive function. However, the investigators expect to observe positive changes between the pre- and post-assessments, suggesting improved cognitive function and mobility as a result of the 12-week program.
Description: Total number of people enrolled divided by the total number of people invited to participate (multiplied by 100 to calculate a percentage)
Measure: Recruitment Rate Time: Pre-program (baseline)Description: Percentage of people who completed the full program and all assessments
Measure: Completion Rate Time: Through study completion, 12 weeksDescription: Percentage of people who attended program sessions (exercise and cognitive training components)
Measure: Attendance Time: Throughout entire intervention (12 weeks, 2 sessions/week per group)Description: Participant and instructors rating of program components and overall program (via hand-written questionnaire). Participants and instructors must rate their level of agreement (1 = strongly disagree, 2 = disagree, 3 = no opinion, 4 = agree, 5 = strongly agree) with various statements. The higher the rating, the greater the satisfaction. They also must rate if the difficulty of the program was optimal, somewhat easy or hard, or too easy or hard. They must also specify how much money they would be willing to spend on the program. They are also given an opportunity to record optional additional comments/recommendation.
Measure: Change in Participant and Instructor Rating of experience, satisfaction, and feasibility of program Time: Mid-point (6 weeks) and post-program (12 weeks)Description: Financial cost of running program (equipment purchased for study - cognitive training tablet and stands - and YMCA staff pay) as reported by researcher and YMCA staff
Measure: Cost of program Time: Post-program (12 weeks)Description: Self-reported biological sex (at birth) using basic demographics questionnaire
Measure: Sex Time: Pre-program (baseline)Description: One-on-one interview with researcher, answering broad questions about their experience in the program and study
Measure: Participant and Instructor perceived program experience and satisfaction Time: Post-program (at 12 weeks)Description: Experience of participants and instructors will also be observed by the researcher (observational notes will be taken by the researcher during each class). No names of participants and instructors will be recorded.
Measure: Participant and Instructor observer-perceived program experience and satisfaction Time: Throughout entire intervention (12 weeks, 2 sessions/week per group)Description: Self-reported years of formal education and training (training years for instructors only) using basic demographics questionnaire
Measure: Education Time: Pre-program (baseline)Description: Self-reported previous and current occupations using basic demographics questionnaire
Measure: Occupation Time: Pre-program (baseline)Description: Self-reported previous and current medical conditions using basic demographics questionnaire
Measure: Medical Condition Time: Pre-program (baseline)Description: Self-reported previous and current medications using basic demographics questionnaire
Measure: Medications Time: Pre-program (baseline)Description: Using the Montreal Cognitive Assessments (brief clinical tool) to assess visual/spatial abilities, working memory, executive functioning, language, abstraction, and orientation). Will be used to describe participants' baseline cognitive status (a score out of 30 is measured).
Measure: Montreal Cognitive Assessment (global cognitive function) Time: Pre-program (baseline)Description: Using the International Physical Activities Questionnaire (IPAQ) to assess physical activity level based on self-reported frequency and duration of job-related, house work-related, transportation-related, and leisure-related physical activities done in the past week. METS-minutes/week will be calculated and reported (i.e. take the number of minutes doing an activity in the past week and multiply by the appropriate metabolic equivalent, which will vary based on the intensity of the physical activity).
Measure: Physical Activity Level Time: Pre-program (baseline)Description: Using a cognitive activity scale (score of 0-4 per activity) that requires participants to self-report how often they typically engage in a variety of mentally stimulating activities (i.e. playing card games, reading, cooking, etc.) The more frequently they engage in the activity, the higher the score.
Measure: Participant cognitive activity Time: Pre-program (baseline)Description: Using a scale (score of 0-3 per group) that requires participants to self-report how often they typically interact (face-to-face or virtually) with different groups of people (i.e. their spouse, family, friends, co-workers, etc.). The more frequently they interact with the group, the higher the score.
Measure: Participant social activity Time: Pre-program (baseline)Description: Self-reported years of age using basic demographics questionnaire
Measure: Participant and Instructor Age Time: Pre-program (baseline)Description: STROOP task which assesses the length of time (seconds) it takes for a participant to correctly name a coloured square (test 1), read the name of a colour (test 2), and say the name of the colour that a word is printed in (test 3). Number of corrected and uncorrected errors are also recorded.
Measure: Change in Stroop Task Performance Time: Pre-program (baseline) and post-program (12 weeks)Description: Trails Making Test Part A and B. Part A assesses visual search (participants must connect numbered circles in ascending numerical order (1-2-3-etc). Part B assesses working memory and task-switching (participants must connect circles in ascending numerical and alphabetical order (1-A-2-B- etc.). Time to complete the tests (second) and errors (number) made during the tests are recorded.
Measure: Change in Trail Making Task Performance Time: Pre-program (baseline) and post-program (12 weeks)Description: Resting (seated) heart rate (beats per minute) using an automatic blood pressure cuff
Measure: Change in Resting Heart Rate Time: Pre-program (baseline) and post-program (12 weeks)Description: Resting (seated) blood pressure (millimeters of mercury) using an automatic blood pressure cuff
Measure: Change in Resting Systolic and Diastolic Blood Pressure Time: Pre-program (baseline) and post-program (12 weeks)Description: Using hand dynamometer (assessing grip strength in lbs) for right and left hand (two trials per hand)
Measure: Change in Grip Strength Time: Pre-program (baseline) and post-program (12 weeks)Description: Weight (using automatic scale to measure in lbs, converted to kg) and height (measured in feet and inches, converted to meters) measured and combined to provide BMI (kg/m^2)
Measure: Change in Body Mass Index (BMI) Time: Pre-program (baseline) and post-program (12 weeks)Description: Divide waist circumference (cm) by hip circumference (cm) to get ratio calculation
Measure: Change in Hip-to-Waist Circumference Ratio Time: Pre-program (baseline) and post-program (12 weeks)Description: Agility and functional balance will be assessed using the Timed Up-and-Go (participants stand up from a chair, walk 6 meters, turn around an object, walk back to chair, and sit down). Time to complete test is measured (seconds) and assessor's observational notes of performance are taken.
Measure: Change in Timed Up-and-Go Performance Time: Pre-program (baseline) and post-program (12 weeks)Description: Agility and functional balance will be assessed using the Four Square Step Test (participants must step over lines that are set up in a cross formation, creating 4 quadrants. They must step forward, backward, and side to side in a specific pattern (i.e. from quadrant 1 to quadrant 2, to quadrant 3, to quadrant 4). Time to complete test is recorded in seconds.
Measure: Change in Four Square Step Test Performance Time: Pre-program (baseline) and post-program (12 weeks)Description: Lower body strength will be assessed using the 5 Time Sit-to-Stand (participants must complete 5 sit-to-stands from a chair as fast as they can). Time to complete all 5 is recorded in seconds.
Measure: Change in Sit-to-Stand Performance Time: Pre-program (baseline) and post-program (12 weeks)Description: Functional fitness will be assessed using the 6 minute walk (participants walk along indoor track for 6 minutes). The number of laps achieved in 6 minutes is recorded. Assessor's observational notes of walking performance is also recorded.
Measure: Change in 6-minute walk test Performance Time: Pre-program (baseline) and post-program (12 weeks)Description: Well-being will be self-reported using the "Vitality-Plus Scale" (self-reported general health questionnaire - rating of sleep quality, appetite, general energy level, etc.). Participants rate their degree of health on a scale from 1 - 5 (the higher the rating, the better their perceived overall well-being).
Measure: Change in Overall Well-being Time: Pre-program (baseline) and post-program (12 weeks)Description: Bandura Scale (named after the researcher who developed it) - self-reported rating of confidence (0 - 100%) to continue exercising routinely in various hypothetical situations (i.e. if one is sick, if the weather is poor, etc). The greater the confidence, the higher the score
Measure: Change in Exercise-related Self-Efficacy Time: Pre-program (baseline) and post-program (12 weeks)Alphabetical listing of all HPO terms. Navigate: Correlations Clinical Trials
Data processed on September 26, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.
Drug Reports MeSH Reports HPO Reports