Developed by Shray Alag, The Harker School
Sections: Correlations,
Clinical Trials, and HPO
Navigate: Clinical Trials and HPO
Navigate: Correlations HPO
There is one clinical trial.
A pilot study of the effects of Bacillus Calmette-Guérin (BCG) immunization on cerebrospinal fluid and blood-based biomarkers in older adults.
Description: Change in concentration of circulating cytokines in CSF from baseline
Measure: CSF biomarkers of pharmacodynamic response- cytokines Time: Day 84Description: Change in Treg number and proportion relative to total CD4+ and CD8+ T cells in CSF from baseline
Measure: CSF biomarkers of pharmacodynamic response-Treg Time: Day 84Description: Change in soluble TNF receptor (sTNF-R) concentration in CSF from baseline
Measure: CSF biomarkers of pharmacodynamic response-TNFR Time: Day 84Description: Change in concentration of ATN markers of AD pathophysiology (Amyloid-β42/40, phospho-tau, total tau and neurofilament light protein biomarkers) in CSF from baseline.
Measure: CSF biomarkers of AD pathology-ATN Time: Day 84Description: Change in BCG on molecular markers of immune response (YKL40, and sTREM2) concentration from from Baseline.
Measure: CSF biomarkers of immune response. Time: Day 84Description: Change in concentration of circulating cytokines in blood from baseline.
Measure: Blood biomarkers of pharmacodynamic response- cytokines Time: Day 28Description: Change in concentration of Treg number and proportion (relative to total CD4+ and CD8+ T cells) in blood from baseline.
Measure: Blood biomarkers of pharmacodynamic response-Treg Time: Day 28Description: Change in concentration of Soluble TNF receptor (sTNF-R) in blood from baseline.
Measure: Blood biomarkers of pharmacodynamic response-TNFR Time: Day 28Description: Change in concentration of circulating cytokines in blood from baseline
Measure: Blood biomarkers of pharmacodynamic response- cytokines Time: Day 84Description: Change in Treg number and proportion relative to total CD4+ and CD8+ T cells in blood from baseline
Measure: Blood biomarkers of pharmacodynamic response- Treg Time: Day 84Description: Change in soluble TNF receptor (sTNF-R) concentration in blood from baseline
Measure: Blood biomarkers of pharmacodynamic response- TNFR Time: Day 84Description: Change in concentration of ATN markers of AD pathophysiology (Amyloid-β42/40, phospho-tau, total tau and neurofilament light protein biomarkers) in blood from baseline.
Measure: Blood biomarkers of AD pathology Time: Day 28Description: Change in concentration of ATN markers of AD pathophysiology (Amyloid-β42/40, phospho-tau, total tau and neurofilament light protein biomarkers) in blood from baseline.
Measure: Blood biomarkers of AD pathology Time: Day 84Description: Change from baseline in Clinical Dementia Rating Sum-of-Boxes (CDR-SOB) score. Score range= 0-18 (0=unimpaired, 18=severe dementia)
Measure: Cognitive Measures (CDR) Time: Day 28Description: Change from baseline in Clinical Dementia Rating Sum-of-boxes (CDR-SOB) score. Score range= 0-18 (0=unimpaired, 18=severe dementia)
Measure: Cognitive Measures (CDR) Time: Day 84Description: Change from baseline in Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) score.
Measure: Cognitive Measures (RBANS) Time: Day 28Description: Change from baseline in Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) score
Measure: Cognitive Measures (RBANS) Time: Day 84Alphabetical listing of all HPO terms. Navigate: Correlations Clinical Trials
Data processed on September 26, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.
Drug Reports MeSH Reports HPO Reports