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Sections: Correlations,
Clinical Trials, and HPO
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Name (Synonyms) | Correlation | |
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drug392 | Attention Control Group Wiki | 1.00 |
drug911 | Chloroquine or hydroxychloroquine Wiki | 0.71 |
drug3319 | Remdesivir Wiki | 0.19 |
Name (Synonyms) | Correlation | |
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D000070642 | Brain Injuries, Traumatic NIH | 0.33 |
D001930 | Brain Injuries, NIH | 0.28 |
D014947 | Wounds and Injuries NIH | 0.17 |
Name (Synonyms) | Correlation |
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Navigate: Correlations HPO
There is one clinical trial.
The purpose of this RCT is to examine the efficacy of a Group Lifestyle Balance™ (GLB) program adapted for people with traumatic brain injury (TBI) on primary (weight) and secondary outcomes at 3, 6, 12, and 18 months from enrollment into the program.
Description: Weight will be obtained using the same scale over the study period that is accessible to people with and without a mobility device (e.g. walker; wheelchair)
Measure: Change in weight Time: Baseline, 3 months, 6, months, 12 months, and 18 monthsDescription: The Garmin Vivofit will be worn for the study duration to measure physical activity data.
Measure: Step Count Time: 3 months, 6 months, 12 months, and 18 monthsDescription: Waist circumference will be measured at the umbilicus and mild-upper arm circumference following American College of Sports Medicine guidelines.
Measure: Waist and Arm Circumference Time: Baseline, 3 months, 6 months, 12 months, and 18 monthsDescription: Using an automatic cuff (average of three readings, patient seated) diastolic and systolic scores will be recorded.
Measure: Blood Pressure Time: Baseline, 3 months, 6 months, 12 months, and 18 monthsDescription: Fasting venous sample will be obtained for blood glucose, HDL/LDL, cholesterol, and triglyceride level.
Measure: HbA1c and Lipid Panel Time: Baseline, 3 months, 6 months, 12 months, and 18 monthsDescription: The Framingham Heart Study diabetes risk score will be calculated using predictors including age, gender, fasting glucose, body mass index, HDL cholesterol and triglyceride levels, blood pressure, and parental history. Risk score calculator and regression model are free and used in GLB weight-loss trials. Each risk predictor is assigned points ranging from. Risk factors are combined and a total score is calculated, with higher scores designating greater 8-year risk.. The age range for this score is 45 years or older, and therefore only individuals over this age will have calculated scores. Furthermore, the minimum cut-off score is 3.
Measure: Risk of Diabetes Time: Baseline, 3 months, 6 months, 12 months, and 18 monthsDescription: Satisfaction with life will be measured using the Satisfaction with Life Scale (SWLS). The SWLS is a 5-item scale designed to measure global cognitive judgements of one's life satisfaction. Participants indicate how much they agree or disagree with each of the 5 items using a 7-point scale that ranges from 7-strongly agree to 1-strongly disagree. Scores are added together and a total score is calculated, with higher scores signifying higher satisfaction with life and lower scores signifying lower satisfaction with life.
Measure: Satisfaction with Life Time: Baseline, 3 months, 6 months, 12 months, and 18 monthsDescription: TSH, Cortisol, IL-6, THNF, BDNF, IGF, and VEGF will be collected.
Measure: Biomarkers Time: Baseline, 3 months, 6 months, 12 months, and 18 monthsDescription: Assesses walking speed in (m/s) which is correlated to mobility in the community, capacity to perform ADLs, risk of falls, re-hospitalization, and risk of cognitive decline.
Measure: 10 Meter Walk Test (10MWT) Time: Baseline, 3 months, 6 months, and 12 monthsDescription: Assesses distance walked (rolled for wheelchair users) over 6 minutes as a sub-maximal test of aerobic capacity.
Measure: 6 Minute Walk Test (6MWT) Time: Baseline, 3 months, 6 months, and 12 monthsDescription: Social Support for Diet and Exercise Behaviors Scale is a 23-item survey including four subscales: support for healthy eating (5 items); support for physical activity (11 items); social undermining for healthy eating (5 items) and physical activity (2 items). Each item is rated on a scale of 1 to 5 (1 none; 5 very often), with respondents asked to rate support from family, friends, and coworkers. Higher scores represent greater support and internal consistency ranged from Cronbach's α 0.72-0.76.
Measure: Social Support assessed by the Social Support for Diet and Exercise Behaviors Scale Time: Baseline, 3 months, 6 months, 12 months, and 18 monthsDescription: The Feasibility and Usability survey includes 14 items that assesses the participant's subjective experience with the App, level of difficulty, prompting sequence, length, and understanding. Scores above 3 on the scale (1 [totally disagree] - 5 [totally agree]) indicate that the App was easy to use.
Measure: App Feasibility and Usability using the Feasibility and Usability Survey Time: 6 months, 12 months, and 18 monthsDescription: NEWS assesses residents' perception of neighborhood design features, categorized into subscales related to physical activity, including residential density, land use mix (including both indices of proximity and accessibility), street connectivity, infrastructure for walking/cycling, neighborhood aesthetics, traffic and crime safety, and neighborhood satisfaction. Subscales are scored as a mean of items. Higher scores denote higher walkability.
Measure: Neighborhood Walkability assessed by the Neighborhood Environment Walkability Scale (NEWS) Time: Baseline and 12 monthsDescription: Measure includes 28 items that assess health practices among people with disabilities and yields a total Health Practices score plus 4 subscales scores regarding Exercise, Nutrition, Health Practices, and Psychological Well Being. Items are rated on a 5-point scale from 0 'not at all' to 4 'completely.' Scores range from 0-28 with higher scores indicating higher exercise self-efficacy.
Measure: Self-Reported Activities of Health using the Self-Reported Activities of Health for Health Promotion Scale Time: Baseline, 12 months, and 18 monthsDescription: This inventory consists of 40 life events and asks the participant to recall if any of the events happened within the previous year (e.g., death of spouse; personal illness; change in sleep). Endorsement of these events are totaled and higher scores indicate a greater amount of stressful life events. Point values for the Holmes and Rahe Stress Inventory were weighted and summed for each individual based on scoring instructions. Individuals who scored 150 points or less were categorized as low susceptibility to a health breakdown in the next two years, 151-300 points were 50% chance of health breakdown, and 301 points or more were 80% chance of health breakdown.
Measure: Stressful Life Events assessed by the Holmes and Rahe Stress Inventory Time: Baseline, 3 months, 6 months, 12 months, and 18 monthsDescription: The GLB TBI/Attention Control groups will both use this app. Usage and engagement will be collected.
Measure: App Data Time: 6 months, 12 months, and 18 monthsDescription: The MOCA is a brief, 8-section assessment of various cognitive domains including executive function, memory, language, attention, concentration, orientation, and working memory in neurologic populations. Each item on the MOCA is allocated a set of points adding up to 30.
Measure: Executive Function assessed by the Montreal Cognitive Assessment Time: Baseline, 3 months, and 12 monthsDescription: Self-Report Habit Index measures self-reported perceptions of habit strength for an identified behavior. The measure has high internal reliability across four studies. The measure consists of 12 items using a 7-point Likert scale ranging from "completely disagree" to "completely agree", with higher scores representing greater perception of habit strength.
Measure: Self-reported perceptions of habit strength assessed by the Self-Report Habit Index (SRHI) Time: Baseline, 3 months, and 12 monthsDescription: The PHQ-8 is a brief self-report measure of major depressive disorder, derived from the PHQ-9 by removing the last question regarding suicide assessment.It is considered to be a valid measure of depression for population-based studies and clinical populations, and has been used in studies of patients with physical injury. Frequency of symptoms during the last 2 weeks is assessed on a 0 (not at all) to 3 (nearly every day) scale. A cut-off score of 10 or greater is considered diagnostic for current depression
Measure: Depression assessed using the Patient Health Questionnaire-8 item Time: Baseline, 12 months, and 18 monthsDescription: Walk Score is publically available and measures walkability of any address using a patented system. Fore each address, Walk Score analyzes hundreds of walking routes to nearby amenities and awards points based on distance to each amenities. Scores are given on a scale of 0 to 100.
Measure: Walk Score Time: Baseline and 12 monthsDescription: The BAST is a 47 item, theoretically grounded, validated survey of behavioral and emotional symptoms for community-based adults with TBI. This assessment is a shortened version of the validated 77-item survey, with questions related to environmental stressors and mood removed due to repetitiveness to other questions in survey packet. Responses are asked over the past two weeks using an ordinal scale from 0 "rarely" to 5 "very often." There are 6 subscales: Negative Affect, Substance Use, Executive Function, Fatigue, Impulsivity, and Maladaptive Coping. Higher scores indicate more symptoms in those domains. This measure will be used to characterize behavioral/emotional symptoms and to explore whether these are factors that influence
Measure: Behavioral Assessment Time: Baseline and 6 monthsDescription: The ten items from the General Self-Efficacy Scale (GSE) are deigned to examine goal-setting, effort investment, persistence in face of barriers and recovery from setbacks as constructs of perceived self-efficacy. The total score is the sum ranging from 10-40 and the instrument has been normed against the U.S. Adult population with a mean score of 29.48.
Measure: General Self Efficacy Time: Baseline, 12 months, and 18 monthsDescription: The BRFSS is a state-based system of health surveys that collects information on health risk behaviors, preventative health practices, and health care access primarily related to chronic disease and injury. The GLB-TBI uses the two subscales of Healthy Eating and Physical Activity from the 2017 version of the BRFSS. It consists of 14 items.
Measure: Behavioral Risk Factor Surveillance Time: Baseline, 3, 6, 12, and 18 months.Description: This is an FDA cleared and validated indirect calorimetry device. It is handheld and measures oxygen consumption (V02) to determine resting metabolic rate (RMR)
Measure: MedGem Time: BaselineDescription: The metabolic score calculator will be used at all time points to determine the risk for metabolic syndrome. The following variables will be used to determine metabolic risk using the free metabolic risk calculator: gender, race and ethnicity, systolic blood pressure, fasting glucose, triglycerides, high-density lipoprotein (HDL), weight, height, and waist circumference. Scores are calculated are standardized to the general population.
Measure: Metabolic Score Calculator (MetS) Time: Baseline, 3, 6, 12, and 18 monthsDescription: Information on substance use will be collected using the AUDIT-C (for alcohol use) and three questions regarding tobacco and non-prescriptive drug use.
Measure: Substance Use Time: Baseline, 12 monthsDescription: This self-report survey was developed by the National Institute of Mental Health. The full survey consists of 64 questions with an open-ended section at the end to elicit concerns and feedback related to the effects of COVID-19. For this current study, however, only sections on Exposure Status (10 items), Life Changes (15 items), and Emotions/Worries (7 items), and the open-ended question will be asked. Questions are asked "over the past two weeks."
Measure: CRISIS (CoRonavIruS Health Impact Survey) V0.3 Adult Baseline Form Time: Up to 12 monthsDescription: The Social Isolation Short-Form 4a is taken from the Patient-Reported Outcomes Measurement Information System (PROMIS). This form assesses the perceptions of being "avoided, excluded, detached, disconnected from, or unknown by, others. There is no timeframe for the form. The measure is normed to the US population.
Measure: PROMIS Social Isolation Short Form 4a Time: Up to 12 monthsDescription: To assess media exposure and fear of media exposure during COVID-19 we have added 6 questions. These are asked "over the past two weeks." These questions address time spent watching the television, listening to radio, reading the newspaper, and searching the internet and social media. In addition, a 6th question related to fear is asked using a 5-point Likert scale.
Measure: Media Questionnaire Time: Up to 12 monthsAlphabetical listing of all HPO terms. Navigate: Correlations Clinical Trials
Data processed on September 26, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.
Drug Reports MeSH Reports HPO Reports