Developed by Shray Alag, The Harker School
Sections: Correlations,
Clinical Trials, and HPO
Navigate: Clinical Trials and HPO
| Name (Synonyms) | Correlation | |
|---|---|---|
| drug3273 | Rarefaction Wiki | 0.58 |
| drug2801 | PWV Wiki | 0.58 |
| drug3158 | Pulse oximeter Wiki | 0.58 |
Navigate: Correlations HPO
There are 3 clinical trials
Electrocardiographic (ECG) evaluation of patients with severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection. The present study involves three different phases of evaluation of the ECG traces of hospitalized patients with SARS-CoV-2 infection. - Phase 1: it is proposed to collect and retrospectively analyze the ECGs of hospitalized patients with severe SARS-CoV-2 infection which led to invasive ventilation or patient death as a consequence and, if available, also possible troponin dosage; - Phase 2: aims to collect and analyze the ECGs of consecutive hospitalized patients with SARS-CoV-2 infection and evaluate their relationship with the course of the disease, cardiac involvement and prognosis; - Phase 3: it is proposed to repeat ECG and to carry out echocardiogram to patients with SARS-CoV-2 infection after 3 months from hospital discharge by simultaneously performing, if deemed clinically indicated, also cardiac magnetic resonance. In this phase, any evolutions of ECG alterations of the acute phase will be described and the relationship with cardiac involvement will be assessed.
Description: Describe the ECG characteristics in patients presenting with severe form of SARS-CoV-2 infection
Measure: Phase 1: ECG characteristics in patients presenting with severe form of SARS-CoV-2 infection Time: 1 monthDescription: To evaluate the correlation between ECG signs and cardiac involvement in the acute phase • Assess the correlation between ECG signs and mortality in the acute phase
Measure: Phase 2: Correlation between ECG signs and needs for invasive mechanical ventilation and/or mortality in the acute phase Time: 6 monthsDescription: To evaluate the correlation between acute phase ECG signs and chronic phase cardiac involvement • evaluate the appearance, in the short-term follow-up, of signs of cardiac involvement (cardiomyopathies and conduction disorders in particular)
Measure: Phase 3: Correlation between ECG signs and cardiac involvement and mortality in the chronic phase Time: 12 monthsThe current COVID-19 pandemic (caused by the SARS-CoV-2 virus) represents the biggest medical challenge in decades. Whilst COVID-19 mainly affects the lungs it also affects multiple organ systems, including the cardiovascular system. There are documented associations between severity of disease and risk of death and To provide all the information required by review bodies and research information systems, we ask a number of specific questions. This section invites you to give an overview using language comprehensible to lay reviewers and members of the public. Please read the guidance notes for advice on this section. 5 DRAFT Full Set of Project Data IRAS Version 5.13 advancing age, male sex and associated comorbid disease (hypertension, ischaemic heart disease, diabetes, obesity, COPD and cancer). The most common complications include cardiac dysrhythmia, cardiac injury, myocarditis, heart failure, pulmonary embolism and disseminated intravascular coagulation. It is thought that the mechanism of action of the virus involves binding to a host transmembrane enzyme (angiotensin- converting enzyme 2 (ACE2)) to enter some lung, heart and immune cells and cause further damage. While ACE2 is essential for viral invasion, it is unclear if the use of the common antihypertensive drugs ACE inhibitors or angiotensin receptor blockers (ARBs) alter prognosis. This study aims to look closely at the health of the vascular system of patients after being treated in hospital for COVID-19 (confirmed by PCR test) and compare them to patients who had a hospital admission for suspected COVID-19 (negative PCR test) . Information from this study is essential so that clinicians treating patients with high blood pressure understand the impact of the condition and these hypertension medicines in the context of the current COVID-19 pandemic. This will allow doctors to effectively treat and offer advice to patients currently prescribed these medications or who are newly diagnosed with hypertension.
Description: Ambulatory Blood Pressure Monitoring systolic blood pressure
Measure: ABPM systolic blood pressure Time: 24 hours (all day and night)Description: Ambulatory Blood Pressure Monitoring diastolic blood pressure
Measure: 24-hr ABPM DBP Time: 24 hours (all day and night)Description: Day Ambulatory Blood Pressure Monitoring systolic blood pressure
Measure: day ABPM SBP Time: 8am to 8pmDescription: Day Ambulatory Blood Pressure Monitoring diastolic blood pressure
Measure: day ABPM DBP Time: 8am to 8pmDescription: Night Ambulatory Blood Pressure Monitoring systolic blood pressure
Measure: night ABPM SBP Time: 8pm to 8amDescription: Night Ambulatory Blood Pressure Monitoring diastolic blood pressure
Measure: night ABPM DBP Time: 8pm to 8amDescription: The fall in pressure, called the "dip", is defined as the difference between daytime mean systolic pressure and nighttime mean systolic pressure expressed as a percentage of the day value
Measure: dipping status Time: 24 hours (all day and night)Description: he morning surge was defined as the difference between the mean systolic blood pressure during the 2 hours after waking and arising minus the mean systolic blood pressure during the hour that included the lowest blood pressure during sleep.
Measure: morning surge Time: 24 hours (all day and night)Description: 24 hour Ambulatory Blood Pressure Monitoring heart rate
Measure: 24 hour ABPM HR Time: 24hr (all day and night)Description: Day Ambulatory Blood Pressure Monitoring heart rate
Measure: day ABPM HR Time: 8 am to 8 pmDescription: Night Ambulatory Blood Pressure Monitoring heart rate
Measure: night ABPM HR Time: 8pm to 8 amTimely prediction of impending respiratory failure is vital, yet relies on subjective clinical assessment of the patient's respiratory status. Pulse oximetry plethysmographic signal analysis is indicative of the effort to breathe and may provide an objective measurement of respiratory loading.
Description: Number of patients who fail spontaneous breathing (SB). Failure of SB is defined as death or need of invasive mechanical ventilation whereas SB includes any form of non-invasive ventilatory support
Measure: Rate of failure of spontaneous breathing Time: Day 10Description: Patient's respiratory rate during non-invasive respiratory support as derived from an ECG signal
Measure: Respiratory rate Time: Day 0Description: Peripheral oxygen saturation (SpO2) as measured with a pulse oximeter during any form of non-invasive ventilatory support
Measure: SpO2 under non-invasive respiratory support Time: Day 0Description: Photoplethysmographic variation index following offline computation of the SpO2 curve stored at day 0 according to a proprietary algorithm
Measure: ΔPOP Time: day 0Alphabetical listing of all HPO terms. Navigate: Correlations Clinical Trials
Data processed on September 26, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.
Drug Reports MeSH Reports HPO Reports