|drug2484||NO intervention planned due to the observational study design - only a diagnostic testing Wiki||1.00|
|drug2368||Methylprednisolone Sodium Succinate Wiki||0.71|
|D045169||Severe Acute Respiratory Syndrome NIH||0.04|
There is one clinical trial.
This is a double-blind, randomized, placebo-controlled, phase IIb clinical trial to assess the efficacy of injectable methylprednisolone sodium succinate (MP) in patients with severe acute respiratory syndrome (SARS) in COVID-19 infection. A total of 416 individuals of both sexes, aged over 18 years old, with symptoms suggestive or confirmed diagnosis of severe acute respiratory syndrome (SARS), hospitalized at the Hospital and Pronto-Socorro Delphina Rinaldi Abdel Aziz (HPSDRAA), with clinical and radiological findings suggestive of SARS-CoV2 infection, will be randomized at a 1:1 ration to receive either MP (0.5mg/kg of weight, twice daily, for 5 days) or placebo (saline solution, twice daily, for 5 days).
Description: Mortality rate on day 28, after randomizationMeasure: Mortality rate at day 28 Time: on day 28, after randomization
Description: Proportion of patient that died on days 7, 14 and 28.Measure: Mortality rate on days 7, 14 and 28 Time: after randomization, up to 28 days.
Description: proportion of patients requiring orotracheal intubationMeasure: Incidence of orotracheal intubation Time: after randomization, up to 7 days.
Description: Proportion of patients with oxygenation index (PaO2 / FiO2) < 100 in 7 days.Measure: Change in oxygenation index Time: after randomization, up to 7 days.
Data processed on September 26, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.Drug Reports MeSH Reports HPO Reports