Developed by Shray Alag, The Harker School
Sections: Correlations,
Clinical Trials, and HPO
Navigate: Clinical Trials and HPO
| Name (Synonyms) | Correlation | |
|---|---|---|
| D012595 | Scleroderma, Systemic NIH | 0.71 |
| D012598 | Scoliosi NIH | 0.23 |
| Name (Synonyms) | Correlation |
|---|
Navigate: Correlations HPO
There is one clinical trial.
This is a randomised placebo-controlled study of moderate dose prednisolone for 6 months in patients with early diffuse cutaneous systemic sclerosis (dcSSc). Seventy-two patients within 3 years of the onset of skin thickening will be recruited from 14 UK centres over 3 years. Co-primary end-points will be the Health Assessment Questionnaire Disability Index (HAQ-DI) and the modified Rodnan skin score (mRSS). Patients will be assessed 5 times: screening, baseline, 6 weeks, 3 and 6 months, with a code-break on exit from the study at 6 months. Please note: From August 2020, the trial was re-started following halt due to Covid-19 as open-label. The placebo arm is the 'no treatment' arm and there is no longer a code-break at study exit.
Description: The mean difference in HAQ-DI at 3 months
Measure: Health Assessment Questionnaire Disability Index (HAQ-DI) Time: Baseline to 3 monthsDescription: The difference in mRSS at 3 months
Measure: modified Rodnan Skin Score (mRSS) Time: Baseline to 3 monthsDescription: HAQ-DI
Measure: Quality of life and functional ability - Assessed by Questionnaire Time: Baseline to 6 weeks and 6 monthsDescription: Skin involvement as measured by the mRSS
Measure: Pain and disability Time: Baseline to 6 weeks and 6 monthsDescription: 11-point Scleroderma Functional Index
Measure: Functional ability - Assessed by Questionnaire Time: Baseline to 6 weeks, 3 months and 6 monthsDescription: Assessment of Pruritus
Measure: Pain associated with itch - Assessed by Questionnaire Time: Baseline to 6 weeks, 3 months and 6 monthsDescription: Cochin Hand Function
Measure: Hand function - Assessed by Questionnaire Time: Baseline to 6 weeks, 3 months and 6 monthsDescription: Functional Assessment of Chronic Illness Therapy (FACIT)
Measure: Fatigue - Assessed by Questionnaire Time: Baseline to 6 weeks, 3 months and 6 monthsDescription: Hospital Anxiety and Depression Scale (HADS) . This questionnaire has 14 questions, each with 4 options designed to assess aspects of mental health
Measure: Anxiety and depression - Assessed by questionnaire Time: Baseline to 6 weeks, 3 months and 6 monthsDescription: Helplessness Questionnaire
Measure: Health related quality of life - Assessed by Questionnaire Time: Baseline to 6 weeks, 3 months and 6 monthsDescription: Short Form (36) Health Survey
Measure: Health related quality of life - Assessed by Questionnaire Time: Baseline to 6 weeks, 3 months and 6 monthsDescription: EuroQol 5 Dimensions
Measure: Health related quality of Life - Assessed by Questionnaire Time: Baseline to 6 weeks, 3 months and 6 monthsDescription: Patient Global Assessment
Measure: Pain and disability Time: Baseline to 6 weeks, 3 months and 6 monthsDescription: Physician Global Assessment
Measure: Pain and disability Time: Baseline to 6 weeks, 3 months and 6 monthsDescription: Digital Ulcer Count: The site and total number of ulcers on the hand are recorded by the patients clinician on a diagram of a hand
Measure: Assessment of pain - Clinician assessment Time: Baseline to 6 weeks, 3 months and 6 monthsDescription: Tender Friction Rubs - the total number of tendon friction rubs on 12 possible anatomical sites are recorded
Measure: Assessment of pain - Clinician assessment Time: Baseline to 6 weeks, 3 months and 6 monthsDescription: Joint Count: The number of tender or swollen joints are assessed from 14 anatomical sites (both left and right side) and recorded out of a total of 28 (14 sites, left and right side) tender joints and 28 swollen joints
Measure: Assessment of pain - Clinician assessment Time: Baseline to 6 weeks, 3 months and 6 monthsDescription: Assessment of Arthritis Index
Measure: Pain and disability - Assessed by Questionnaire Time: Baseline to 6 weeks, 3 months and 6 monthsDescription: Assessment in percentage change of mRSS
Measure: Pain and disability Time: Baseline to 6 weeks, 3 months and 6 monthsAlphabetical listing of all HPO terms. Navigate: Correlations Clinical Trials
Data processed on September 26, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.
Drug Reports MeSH Reports HPO Reports