|drug2039||Ivermectin Injectable Solution Wiki||0.71|
|drug2522||Nebulized Sterile Saline Wiki||0.71|
|D045169||Severe Acute Respiratory Syndrome NIH||0.06|
|D018352||Coronavirus Infections NIH||0.05|
There are 2 clinical trials
To evaluate the effectiveness of Nigella Sativa (1 gm seed powder in a capsule orally) and 30 ml of honey stirred in 250 ml of distilled water 12 hourly till patient becomes asymptomatic or a maximum of 14 days with standard hospital care versus standard hospital care alone with placebo capsule and 250 ml water, in clearing the COVID-19 nucleic acid from throat and nasal swab, lowering disease detrimental effects on HRCT chest/X-ray and severity of symptoms along with duration of hospital stay till day 14th day of follow up and 30 days mortality (primary outcomes).
Description: RT-PCR will be done on admission day (0 day) and then after every 4th day for 14 days or till the symptoms resolved and RT-PCR gets negative. RT-PCR will only be shown as positive or negative (as per limitation of Pakistan).Measure: Days required to get a positive COVID-19 PCR to negative Time: upto max 14 days
Description: HRCT will be conducted at admission day (0-day) and a total of maximum four CT-scan will be conducted after every 4th day. The minimum and score at which we label covid-19 positive will be 5 and 25 respectively using internationally standard nomenclature as described by Fleischner Society glossary and peer-reviewed literature on viral pneumonia.Measure: HRCT/ X-ray findings of disease progression Time: upto max 14 days
Description: Clinically disease progression will be evaluated depending upon the severity of symptoms being classified as mild, moderate and severe.Measure: Severity of symptoms progression Time: upto max 14 days
Description: Duration of hospital stay would be categorized as the number of days the patient stayed in the ward during treatment. The date of admission and date of discharge would give us total duration of stay.Measure: Duration of Hospital Saty Time: upto max 14 day
Description: 30 days mortality rate in each armMeasure: 30 day mortality Time: 30 days
Description: every 4th day oxygen saturation at room air will be checked to evaluate the disease progressionMeasure: Oxygen Saturation at room air Time: upto max of 14 days
Description: Involvement of cardiac complications will be assessedMeasure: Incidence of viral myocarditis Time: upto max 14 days
Description: Lethal complication like ARDS will be assessed to evaluate disease severityMeasure: Incidence of Acute respiratory Distress Syndrome Time: upto max 14 days
To measure the effect of Ivermectin (sub-cutaneous) with or without zinc and Nigella sativa in treating the COVID-19 patients to clear viral load of SARS-CoV-2 along with reduction in severity of symptoms and length of hospitalization of patients with COVID-19.
Description: time needed to turn positive COVID-19 PCR to negativeMeasure: qRT-PCR Time: 14 days
Description: time needed to make patients clinically betterMeasure: Severity of symptoms Time: 14 days
Data processed on September 26, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.Drug Reports MeSH Reports HPO Reports