Developed by Shray Alag, The Harker School
Sections: Correlations,
Clinical Trials, and HPO
Navigate: Clinical Trials and HPO
| Name (Synonyms) | Correlation | |
|---|---|---|
| drug2074 | Knowledge, Attitude, Practice, Awareness, Preference Wiki | 1.00 |
| drug3728 | Standard of Care Wiki | 0.16 |
| Name (Synonyms) | Correlation | |
|---|---|---|
| D063806 | Myalgia NIH | 1.00 |
| D004417 | Dyspnea NIH | 0.30 |
| D055370 | Lung Injury NIH | 0.19 |
| Name (Synonyms) | Correlation | |
|---|---|---|
| HP:0003326 | Myalgia HPO | 1.00 |
| HP:0002098 | Respiratory distress HPO | 0.30 |
Navigate: Correlations HPO
There is one clinical trial.
Finding effective strategies to treat or prevent the novel coronavirus disease that started in 2019 (COVID-19) is a global public health priority. Potential therapeutics and vaccines are now being investigated in over 1500 clinical trials. Clinical features of the disease include overproduction of reactive oxygen species which induces oxidative stress responses and contribute to acute lung injury. This presents a potential treatment strategy involving antioxidation therapy. In this pilot study, 90 COVID-19 patients aged 18-75 years will be recruited into two groups. The 45 patients in group 1 will receive the standard of care determined by their primary care providers while the 45 patients in group 2 will receive both the standard of care combined with daily antioxidant supplement for 14 days. All patients will be monitored for a total of 28 days with daily monitoring of symptoms and nasopharyngeal swab for SARS-CoV-2 test on days 3, 7, 14 and 28. The study will compare the following between the two groups: (1) the proportion of patients with clinical improvement (defined as live discharge from hospital, decrease of at least 2 points from baseline on a 7-point ordinal scale, or both), and (2) the proportion of patients with negative SARS-CoV-2 test by PCR on days 3, 7, and 14.
Description: Time to clinical improvement (defined as time from randomization to either an improvement of two points on a 7-category ordinal scale or discharge from the hospital, whichever came first, or both)
Measure: Time to clinical improvement Time: 28 daysDescription: Proportion of participants with SARS-CoV-2 polymerase chain reaction (PCR) negative result at Day 14
Measure: Time to SARS-CoV-2 negativity Time: 14 daysDescription: Clinical status as assessed with the seven-category ordinal scale on day 14
Measure: Clinical status on day 14 Time: 14 daysDescription: Respiratory failure or Acute Respiratory Distress Syndrome, Acute Kidney Injury, secondary infection, shock, severe anemia, acute gastritis, unconsciousness, acute heart failure
Measure: Serious adverse events Time: 28 daysDescription: Nausea, vomiting, and diarrhea
Measure: Gastrointesntinal adverse events Time: 28 daysAlphabetical listing of all HPO terms. Navigate: Correlations Clinical Trials
Data processed on September 26, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.
Drug Reports MeSH Reports HPO Reports