Developed by Shray Alag, The Harker School
Sections: Correlations,
Clinical Trials, and HPO
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| Name (Synonyms) | Correlation | |
|---|---|---|
| drug4564 | mMRC (Modified Medical Research Council) Dyspnea Scale Wiki | 1.00 |
| drug3692 | St. George's Respiratory Questionnaire (SGRQ) Wiki | 1.00 |
| drug4712 | risk factors Wiki | 1.00 |
| Name (Synonyms) | Correlation | |
|---|---|---|
| D016638 | Critical Illness NIH | 0.12 |
| D012127 | Respiratory Distress Syndrome, Newborn NIH | 0.08 |
| D055371 | Acute Lung Injury NIH | 0.08 |
| Name (Synonyms) | Correlation |
|---|
Navigate: Correlations HPO
There is one clinical trial.
Little is currently known about the immediate and long-term effect of COVID-19 on lung ventilation (delivery of air to the lungs) and lung perfusion (delivery of blood to the lungs). Some people who survive COVID-19 may have lung ventilation and/or perfusion injury that persists following COVID-19 recovery. This lung injury may be related to inflammation in the lung, breathlessness, exercise limitation and reduced quality of life. Therefore, towards the goal of understanding the effects of COVID-19 on lung health, the purpose of this study is to characterize and understand the clinical relevance of COVID-19 related lung ventilation and perfusion injury and associated inflammatory status, ≤4 weeks and 6-months following COVID-19 recovery in an asthmatic and healthy population. To do this, an asthmatic and healthy population who have, and have not, been previously diagnosed with COVID-19 will be studied.
Description: The short-term difference in lung ventilation between healthyCOVID-19+ and healthyCOVID-19- participants
Measure: Short-term difference in ventilation defect percent assessed by ventilation SPECT-CT - healthy Time: ≤4-weeks post COVID-19 recovery (Visit 1)Description: The short-term difference in lung perfusion between healthyCOVID-19+ and healthyCOVID-19- participants
Measure: Short-term difference in perfusion defect percent assessed by perfusion SPECT-CT - healthy Time: ≤4-weeks post COVID-19 recovery (Visit 1)Description: The short-term difference in lung ventilation/perfusion mismatch between healthyCOVID-19+ and healthyCOVID-19- participants
Measure: Short-term difference in lung ventilation/perfusion mismatch assessed by ventilation/perfusion SPECT-CT - healthy Time: ≤4-weeks post COVID-19 recovery (Visit 1)Description: The long-term difference in lung ventilation between healthyCOVID-19+ and healthyCOVID-19- participants
Measure: Long-term difference in ventilation defect percent assessed by ventilation SPECT-CT - healthy Time: 6-months post COVID-19 recovery (Visit 2)Description: The long-term difference in lung perfusion between healthyCOVID-19+ and healthyCOVID-19- participants
Measure: Long-term difference in perfusion defect percent assessed by perfusion SPECT-CT - healthy Time: 6-months post COVID-19 recovery (Visit 2)Description: The long-term difference in lung ventilation/perfusion mismatch between healthyCOVID-19+ and healthyCOVID-19- participants
Measure: Long-term difference in ventilation/perfusion mismatch assessed by ventilation/perfusion SPECT-CT - healthy Time: 6-months post COVID-19 recovery (Visit 2)Description: The short-term difference in lung ventilation between asthmaticCOVID-19+ and asthmaticCOVID-19- participants
Measure: Short-term difference in ventilation defect percent assessed by ventilation SPECT-CT - asthmatic Time: ≤4-weeks post COVID-19 recovery (Visit 1)Description: The short-term difference in lung perfusion between asthmaticCOVID-19+ and asthmaticCOVID-19- participants
Measure: Short-term difference in perfusion defect percent assessed by perfusion SPECT-CT - asthmatic Time: ≤4-weeks post COVID-19 recovery (Visit 1)Description: The short-term difference in lung ventilation/perfusion mismatch between asthmaticCOVID-19+ and asthmaticCOVID-19- participants
Measure: Short-term difference in ventilation/perfusion mismatch assessed by ventilation/perfusion SPECT-CT - asthmatic Time: ≤4-weeks post COVID-19 recovery (Visit 1)Description: The long-term difference in lung ventilation between asthmaticCOVID-19+ and asthmaticCOVID-19- participants
Measure: Long-term difference in ventilation defect percent assessed by ventilation SPECT-CT - asthmatic Time: 6-months post COVID-19 recovery (Visit 2)Description: The long-term difference in lung perfusion between asthmaticCOVID-19+ and asthmaticCOVID-19- participants
Measure: Long-term difference in perfusion defect percent assessed by perfusion SPECT-CT - asthmatic Time: 6-months post COVID-19 recovery (Visit 2)Description: The long-term difference in lung ventilation/perfusion mismatch between asthmaticCOVID-19+ and asthmaticCOVID-19- participants
Measure: Long-term difference in ventilation/perfusion mismatch assessed by ventilation/perfusion SPECT-CT - asthmatic Time: 6-months post COVID-19 recovery (Visit 2)Description: Difference in the 6-month change in lung ventilation between healthyCOVID-19+ and healthyCOVID-19- participants
Measure: Longitudinal change in ventilation defect percent assessed by ventilation SPECT-CT - healthy Time: 6-months post COVID-19 recovery (Visit 2)Description: Difference in the 6-month change in lung perfusion between healthyCOVID-19+ and healthyCOVID-19- participants
Measure: Longitudinal change in perfusion defect percent assessed by perfusion SPECT-CT - healthy Time: 6-months post COVID-19 recovery (Visit 2)Description: Difference in the 6-month change in lung ventilation/perfusion mismatch between healthyCOVID-19+ and healthyCOVID-19- participants
Measure: Longitudinal change in ventilation/perfusion mismatch assessed by ventilation/perfusion SPECT-CT - healthy Time: 6-months post COVID-19 recovery (Visit 2)Description: Difference in the 6-month change in lung ventilation between asthmaticCOVID-19+ and asthmaticCOVID-19- participants.
Measure: Longitudinal change in ventilation defect percent assessed by ventilation SPECT-CT - asthmatic Time: 6-months post COVID-19 recovery (Visit 2)Description: Difference in the 6-month change in lung perfusion between asthmaticCOVID-19+ and asthmaticCOVID-19- participants.
Measure: Longitudinal change in perfusion defect percent assessed by perfusion SPECT-CT - asthmatic Time: 6-months post COVID-19 recovery (Visit 2)Description: Difference in the 6-month change in lung ventilation/perfusion mismatch between asthmaticCOVID-19+ and asthmaticCOVID-19- participants.
Measure: Longitudinal change in ventilation/perfusion mismatch assessed by ventilation/perfusion SPECT-CT - asthmatic Time: 6-months post COVID-19 recovery (Visit 2)Description: In COVID-19+ participants, the correlation of lung ventilation with the St. George's Respiratory Questionnaire (SGRQ) score ≤4-weeks post COVID-19 recovery (Visit 1).
Measure: Correlation of lung ventilation with the St. George's Respiratory Questionnaire (SGRQ) score ≤4-weeks post COVID-19 recovery Time: ≤4-weeks post COVID-19 recovery (Visit 1)Description: In COVID-19+ participants, the correlation of lung ventilation with six-minute walk distance (6MWD) ≤4-weeks post COVID-19 recovery (Visit 1).
Measure: Correlation of lung ventilation with six-minute walk distance (6MWD) ≤4-weeks post COVID-19 recovery Time: ≤4-weeks post COVID-19 recovery (Visit 1)Description: In COVID-19+ participants, the correlation of lung ventilation with the forced expiratory volume in one second (FEV1) ≤4-weeks post COVID-19 recovery (Visit 1).
Measure: Correlation of lung ventilation with the forced expiratory volume in one second (FEV1) ≤4-weeks post COVID-19 recovery Time: ≤4-weeks post COVID-19 recovery (Visit 1)Description: In COVID-19+ participants, the correlation of lung ventilation with the diffusing capacity of the lung for carbon monoxide (DLCO) ≤4-weeks post COVID-19 recovery (Visit 1).
Measure: Correlation of lung ventilation with the diffusing capacity of the lung for carbon monoxide (DLCO) ≤4-weeks post COVID-19 recovery Time: ≤4-weeks post COVID-19 recovery (Visit 1)Description: In COVID-19+ participants, the correlation of lung ventilation with the St. George's Respiratory Questionnaire (SGRQ) score 6-months post COVID-19 recovery (Visit 2).
Measure: Correlation of lung ventilation with the St. George's Respiratory Questionnaire (SGRQ) score 6-months post COVID-19 recovery Time: 6-months post COVID-19 recovery (Visit 2)Description: In COVID-19+ participants, the correlation of lung ventilation with six-minute walk distance (6MWD) 6-months post COVID-19 recovery (Visit 2).
Measure: Correlation of lung ventilation with six-minute walk distance (6MWD) 6-months post COVID-19 recovery Time: 6-months post COVID-19 recovery (Visit 2)Description: In COVID-19+ participants, the correlation of lung ventilation with the forced expiratory volume in one second (FEV1) 6-months post COVID-19 recovery (Visit 2).
Measure: Correlation of lung ventilation with the forced expiratory volume in one second (FEV1) 6-months post COVID-19 recovery Time: 6-months post COVID-19 recovery (Visit 2)Description: In COVID-19+ participants, the correlation of lung ventilation with the diffusing capacity of the lung for carbon monoxide (DLCO) 6-months post COVID-19 recovery (Visit 2).
Measure: Correlation of lung ventilation with the diffusing capacity of the lung for carbon monoxide (DLCO) 6-months post COVID-19 recovery Time: 6-months post COVID-19 recovery (Visit 2)Alphabetical listing of all HPO terms. Navigate: Correlations Clinical Trials
Data processed on September 26, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.
Drug Reports MeSH Reports HPO Reports