Developed by Shray Alag, The Harker School
Sections: Correlations,
Clinical Trials, and HPO
Navigate: Clinical Trials and HPO
| Name (Synonyms) | Correlation | |
|---|---|---|
| drug1598 | GLS-1027 Wiki | 1.00 |
| drug1795 | Hydroxychloroquine Sulfate Wiki | 0.29 |
| drug2916 | Placebo Wiki | 0.04 |
Navigate: Correlations HPO
There is one clinical trial.
This is a three-arm randomized trial comparing the efficacy of single agent hydroxychloroquine to the combination of hydroxychloroquine and azithromycin, and to a delayed hydroxychloroquine regimen, which will serve as a contemporaneous Day 1-6 supportive care control, in eliminating detectable SARS-CoV-2 on day 6 following the initiation of treatment in order to determine which regimen is more effective.
Description: Will be assessed at day six compared to baseline between hydroxychloroquine sulfate alone and hydroxychloroquine sulfate plus azithromycin to treat COVID-19.
Measure: Changes in patients viral load Time: Baseline, day 3 and day 6Description: A second concurrent comparison will evaluate change in viral load at day 6 between hydroxychloroquine sulfate alone and supportive care.
Measure: Second evaluation of changes in patients viral load Time: Day 6Description: Time to resolution of symptoms
Measure: Symptom questionnaire Time: up to 6 monthsDescription: Change in the fever curve resulting in shorter time to afebrile for 48 hours
Measure: Fever assessment Time: up to 10 daysDescription: Body temperature will be measured in degrees Fahrenheit using an automated thermometer which will be provided to the patient 4 times per day.
Measure: Vital Signs - Body Temperature Time: up to 10 daysDescription: Time to discharge (If hospitalized)
Measure: Discharge Time: up to 6 monthsDescription: Time to recovery (back to school, work, etc)
Measure: Recovery Time: up to 6 monthsDescription: As measured by standard metrics
Measure: Assessment of agent toxicity Time: up to 10 daysDescription: Collection of Oropharynx swabs for viral load and microbiome analysis
Measure: Oropharynx swab sample collections Time: up to 10 daysDescription: Collection of blood for viral load and microbiome analysis
Measure: Blood Sample collections Time: up to 10 daysDescription: Decrease in virus shedding in nasopharyngeal secretions such as Ferritin, D-dimer, CRP, Troponin and LDH
Measure: Viral shedding assessment - nasopharyngeal secretions Time: up to 10 daysDescription: Decrease in virus shedding in serology such as Ferritin, D-dimer, CRP, Troponin and LDH
Measure: Viral shedding assessment - serology Time: up to 10 daysDescription: Measurement of cytokines in blood
Measure: Cytokines in blood Time: up to 10 daysAlphabetical listing of all HPO terms. Navigate: Correlations Clinical Trials
Data processed on September 26, 2020.
An HTML report was created for each of the unique drugs, MeSH, and HPO terms associated with COVID-19 clinical trials. Each report contains a list of either the drug, the MeSH terms, or the HPO terms. All of the terms in a category are displayed on the left-hand side of the report to enable easy navigation, and the reports contain a list of correlated drugs, MeSH, and HPO terms. Further, all reports contain the details of the clinical trials in which the term is referenced. Every clinical trial report shows the mapped HPO and MeSH terms, which are also hyperlinked. Related HPO terms, with their associated genes, protein mutations, and SNPs are also referenced in the report.
Drug Reports MeSH Reports HPO Reports