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High PEEP without end inspiratory pauseWiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (3)

Name (Synonyms) Correlation
drug1614 Low PEEP - FiO2 high Wiki 1.00
drug1248 High PEEP with end inspiratory pause Wiki 1.00
drug1615 Low PEEP - FiO2 low Wiki 1.00

Correlated MeSH Terms (1)

Name (Synonyms) Correlation
D012128 Respiratory Distress Syndrome, Adult NIH 0.08

Correlated HPO Terms (0)

Name (Synonyms) Correlation

There is one clinical trial.

Clinical Trials

1 Respiratory System Mechanics and Gas Exchange Characteristics Applying Different Ventilatory Strategies in Patients With SARS-CoV-2

The combination of different ventilatory strategies and its effects on respiratory mechanics and gas exchange in patients under mechanical ventilation with acute respiratory distress syndrome secondary to coronavirus-19 has been scarcely described.

NCT04486729 Covid19 ARDS, Human Other: High PEEP with end inspiratory pause Other: Low PEEP - FiO2 high Other: High PEEP without end inspiratory pause Other: Low PEEP - FiO2 low
MeSH:Respiratory Distress Syndrome, Adult

Primary Outcomes

Description: The driving transpulmonary pressure will be evaluated between the high and low PEEP condition using the formula: driving transpulmonary pressure = driving airway pressure - driving esophageal pressure (cmH2O).

Measure: Driving transpulmonary pressure (cmH2O)

Time: 10 minutes

Description: The Bohr dead space fraction will be evaluated with high PEEP between the condition with end inspiratory pause and with no end inspiratory pause application using the formula: Bohr dead space fraction = Alveolar pressure of CO2 (PACO2) - Expired pressure of CO2 (PECO2) / PACO2

Measure: Bohr dead space fraction (%)

Time: 10 minutes

Description: The shunt fraction will be evaluated with low PEEP between the condition with high fraction of oxygen to achieve a saturation goal of 96-98% and the condition with low fraction of oxygen to achieve a saturation goal of 88-92%. The shunt fraction will be calculated using the formula: Qs/Qt = (capillary oxygen content - arterial oxygen content)/(capillary oxygen content - venous oxygen content)

Measure: Shunt fraction (%)

Time: 10 minutes

No related HPO nodes (Using clinical trials)