Name (Synonyms) | Correlation |
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Name (Synonyms) | Correlation |
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There is one clinical trial.
There is a considerable variation in the disease behavior in terms of contracting the infection, manifesting none to a range of symptoms and severity of the infection among individuals exposed to or infected with SARS-CoV-2 virus, the causative organism of COVID-19. Although the respiratory system appears to be the primary target of this virus infection, emerging evidences suggests involvement of extra-pulmonary organs including central nervous system. We aim to compare the genetic profile of individuals with vs without COVID-19 after being exposed to infected cases. Additionally, we will assess the cognitive function in covid-19 positive cases with vs. without neurological symptoms at the time of infection and 1-month follow-up using the Montreal Cognitive Assessment (MoCA) questionnaire.
Description: Evaluate variants in the following known COVID-associated genes, ACE2R, IFITM, HLA-B 46, HLA-B 15, Toll Like Receptor and IFN-1, LIST, Perforin and mutations in Chromosome 3p21.31 along with novel genetic variants.
Measure: Genetic variants with vs without COVID-19 Time: 1 dayDescription: Assess the cognitive status at baseline using MoCA survey in patients with vs without neurological symptoms
Measure: Cognitive function at baseline Time: 1 dayDescription: change in the MoCA score from baseline in patients with vs without neurological symptoms
Measure: Change in cognitive function at 1 month Time: 1 monthDescription: compare the genetic variants in patients with no or mild to moderate vs severe symptoms
Measure: Genetic analysis Time: 1 day