CovidResearchTrials by Shray Alag


CovidResearchTrials Covid 19 Research using Clinical Trials (Home Page)


Whole exome sequencingWiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (0)


Name (Synonyms) Correlation

Correlated MeSH Terms (1)


Name (Synonyms) Correlation
D007239 Infection NIH 0.05

Correlated HPO Terms (0)


Name (Synonyms) Correlation

There is one clinical trial.

Clinical Trials


1 Genetic Mechanisms Underlying SARS-CoV-2 Infection and the Impact of COVID-19 on Cognitive Function

There is a considerable variation in the disease behavior in terms of contracting the infection, manifesting none to a range of symptoms and severity of the infection among individuals exposed to or infected with SARS-CoV-2 virus, the causative organism of COVID-19. Although the respiratory system appears to be the primary target of this virus infection, emerging evidences suggests involvement of extra-pulmonary organs including central nervous system. We aim to compare the genetic profile of individuals with vs without COVID-19 after being exposed to infected cases. Additionally, we will assess the cognitive function in covid-19 positive cases with vs. without neurological symptoms at the time of infection and 1-month follow-up using the Montreal Cognitive Assessment (MoCA) questionnaire.

NCT04506229 Covid19 Genetic: Whole exome sequencing
MeSH:Infection

Primary Outcomes

Description: Evaluate variants in the following known COVID-associated genes, ACE2R, IFITM, HLA-B 46, HLA-B 15, Toll Like Receptor and IFN-1, LIST, Perforin and mutations in Chromosome 3p21.31 along with novel genetic variants.

Measure: Genetic variants with vs without COVID-19

Time: 1 day

Description: Assess the cognitive status at baseline using MoCA survey in patients with vs without neurological symptoms

Measure: Cognitive function at baseline

Time: 1 day

Secondary Outcomes

Description: change in the MoCA score from baseline in patients with vs without neurological symptoms

Measure: Change in cognitive function at 1 month

Time: 1 month

Description: compare the genetic variants in patients with no or mild to moderate vs severe symptoms

Measure: Genetic analysis

Time: 1 day


No related HPO nodes (Using clinical trials)