There is one clinical trial.
This study will explore the preliminary efficacy of multiple intra-articular injections of LRX712 by evaluating the ability of the drug to restore structural integrity of articular cartilage. Efficacy will be evaluated in the context of the systemic safety and local tolerability of the investigational drug.
Description: Efficacy of multiple intra-articular injections of LRX712 in regenerating cartilage as measured with 7T MRI
Measure: Changes in articular cartilage [23Na] content from baseline compared to placebo at week 28 Time: Baseline and Week 28Description: Efficacy of multiple intra-articular injections of LRX712 measured with 7T MRI
Measure: Changes in articular cartilage [23Na] content from baseline compared to placebo at Week 16 and 52 Time: Baseline, Week 16 and 52Description: Efficacy of multiple intra-articular injections of LRX712 measured with 7T MRI
Measure: Changes from baseline in cartilage morphometrics (volume and thickness) in the medial femoral condyle at Week 16, 28 and 52 Time: Baseline, Week 16, 28 and 52Description: The observed time to reach max (Tmax) plasma concentration following drug administration
Measure: Time to Reach the Maximum Plasma Concentration (Tmax) Time: Pre-dose to 28 weeksDescription: The observed maximum (Cmax) plasma concentration following drug administration
Measure: Maximum Observed Plasma Concentration (Cmax) Time: Pre-dose to 28 weeksDescription: The observed minimum (Cmin) plasma concentration following drug administration
Measure: Minimum Observed Plasma Concentration (Cmin) Time: Pre-dose to 28 weeksDescription: The observed synovial concentration following drug administration
Measure: Concentration in synovial fluid Time: Day 1; week 4; week 8