Correlated Drug Terms (1)

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	Name (Synonyms)	Correlation
drug2122	Placebo Wiki	0.05

Correlated MeSH Terms (1)

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	Name (Synonyms)	Correlation
D007239	Infection NIH	0.05

Correlated HPO Terms (0)

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	Name (Synonyms)	Correlation

Primary Outcomes

Description: Mean difference in alveolar oxygen pressure to inspired oxygen fraction (Pa/Fi) ratios.

Measure: Arterial Oxygenation

Time: One hour after sildenafil administration

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Description: Mean difference in alveolar oxygen pressure to inspired oxygen fraction (Pa/Fi) ratios.

Measure: Arterial Oxygenation

Time: Daily until the end of follow-up (up to 15 days after randomisation)

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Description: Mean difference in the alveolo-arterial gradient between study groups.

Measure: Alveolo-arterial gradient

Time: One hour after sildenafil administration

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Description: Mean difference in the alveolo-arterial gradient between study groups.

Measure: Alveolo-arterial gradient

Time: Daily until the end of follow-up (up to 15 days after randomisation)

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Secondary Outcomes

Description: Proportion of patients requiring admission to an intensive care unit in each study group

Measure: Intensive care unit admission

Time: Up to two weeks after randomisation

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Description: Proportion of patients requiring noninvasive mechanical ventilation o high-flow nasal cannula unit in each study group

Measure: Noninvasive Mechanical Ventilation or Requirement of High-Flow Nasal Cannula

Time: Up to two weeks after randomisation

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Description: Proportion of patients requiring invasive mechanical ventilation in each study group

Measure: Invasive mechanical ventilation

Time: Up to two weeks after randomisation

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Description: Proportion of patients that survived COVID19 in each study group

Measure: Survival

Time: Up to two weeks after randomisation

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Other Outcomes

Description: Adverse events attributable to sildenafil use.

Measure: Adverse events

Time: Up to two weeks after randomisation

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