Primary Outcomes
Measure: the area under the stimulated C-peptide response curve Time: over the first 2 hours of a MMTT [ mixed meal tolerance test] at 12 months post treatment
Secondary Outcomes
Measure: the area under the stimulated C-peptide response curve Time: over teh first 2 hours of a MMTT at baseline, 3, 6 and 12 months
Measure: DBS [dry blood spot] C-peptide measurements Time: at all observation times
Measure: CD4 positive T cells and CD8 positive T cells Time: over 12 months
Measure: HBA1c Time: over 12 months
Measure: insulin require months Time: over 12 months
Measure: T1D-associated autoantibodies ( GADA [glutamic acid decarboxylase antibodies], IAA [insulin auto-antibodies], IA-2A [IA-2 antibodies] and ZnT8A Time: over 12 months
Measure: CGM [continuous glucose monitoring] measurements ( time in range, time above time below) Time: over 12 months