CovidResearchTrials by Shray Alag


CovidResearchTrials Covid 19 Research using Clinical Trials (Home Page)


RibavirinWiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (12)


Name (Synonyms) Correlation
drug826 Daclatasvir Wiki 0.58
drug1550 Lactoferrin Wiki 0.50
drug2866 Temporarily holding the RAAS inhibitor [intervention] Wiki 0.50
drug3467 sofosbuvir Wiki 0.50
drug2656 Sofosbuvir Wiki 0.50
drug1556 Ledipasvir Wiki 0.50
drug1784 Moxibustion plus Cupping Wiki 0.50
drug2330 RAAS inhibitor [continued standard of care] Wiki 0.50
drug1437 Interferon beta-1b Wiki 0.35
drug1434 Interferon Beta-1B Wiki 0.29
drug1605 Lopinavir/ritonavir Wiki 0.16
drug2311 Questionnaire Wiki 0.10

Correlated MeSH Terms (6)


Name (Synonyms) Correlation
D002386 Cataract NIH 0.50
D003289 Convalescence NIH 0.22
D002318 Cardiovascular Diseases NIH 0.09
D007239 Infection NIH 0.03
D045169 Severe Acute Respiratory Syndrome NIH 0.02
D018352 Coronavirus Infections NIH 0.02

Correlated HPO Terms (2)


Name (Synonyms) Correlation
HP:0000518 Cataract HPO 0.50
HP:0001626 Abnormality of the cardiovascular system HPO 0.09

There are 4 clinical trials

Clinical Trials


1 An Open-label Randomized Controlled Trial on Lopinavir/ Ritonavir, Ribavirin and Interferon Beta 1b Combination Versus Lopinavir/ Ritonavir Alone, as Treatment for 2019 Novel Coronavirus Infection

A combination of lopinavir/ ritonavir, ribavirin and interferon beta-1b will expedite the recovery, suppress the viral load, shorten hospitalisation and reduce mortality in patients with 2019-n-CoV infection compared with to lopinavir/ ritonavir

NCT04276688 Novel Coronavirus Infection Drug: Lopinavir/ritonavir Drug: Ribavirin Drug: Interferon Beta-1B
MeSH:Infection Coronavirus Infections Severe Acute Respiratory Syndrome

Primary Outcomes

Description: Time to negative NPS 2019-n-CoV RT-PCR

Measure: Time to negative NPS

Time: Up to 1 month

Secondary Outcomes

Description: Time to negative saliva 2019-n-CoV RT-PCR

Measure: Time to negative saliva

Time: Up to 1 month

Description: Time to NEWS of 0

Measure: Time to clinical improvement

Time: Up to 1 month

Description: Length of hospitalisation

Measure: Hospitalisation

Time: Up to 1 month

Description: 30-day mortality

Measure: Mortality

Time: Up to 1 month

Description: Cytokine/ chemokine changes

Measure: Immune reaction

Time: up to 1 month

Description: Adverse events during treatment

Measure: Adverse events

Time: up to 1 month

Description: Time to negative NPS, saliva, urine and stool 2019-n-CoV RT-PCR

Measure: Time to negative all clinical specimens

Time: up to 1 month

2 Sofosbuvir With and Without Ribavirin in Treatment of COVID 19 Patients

Sofosbuvir with and without ribavirin in treatment of COVID 19 Egyptian patients

NCT04460443 COVID Drug: sofosbuvir Drug: Ribavirin Drug: Daclatasvir

Primary Outcomes

Description: The total number of patients with response to treatment

Measure: Number of patients with response to treatment

Time: 1 month

3 An Open-label Randomised Controlled Trial on IFN Beta-1b and Ribavirin Combination, as Treatment for Covid-19 Infection

As of 1 July 2020, more than 10 million people been confirmed to have infected by SARS-CoV-2, resulting in more than 500,000 deaths. No specific antiviral treatment for the SARS-CoV-2 is currently available, but existing medication could be repurposed. The investigators therefore propose to conduct an open-label randomized controlled trial on a short course of interferon β-1b and ribavirin combination treatment for patients hospitalized for COVID-19 infection.

NCT04494399 Covid19 Drug: Interferon beta-1b Drug: Ribavirin

Primary Outcomes

Description: Time to complete alleviation of symptoms as defined by NEWS2 of 0 maintained for 24 hours

Measure: Clinical symptoms alleviation

Time: 7 days

Secondary Outcomes

Description: Length of hospitalisation

Measure: Hospitalisation

Time: 14 days

Description: Time to negative nasopharyngeal swab and throat saliva viral load by RT-PCR

Measure: Time to negative viral load

Time: 7 days

Description: Cytokine/ chemokine changes

Measure: Inflammatory changes

Time: 7 days

Description: One month mortality rate

Measure: Mortality

Time: 30 days

Description: Adverse events and serious adverse events within 30 days of treatment

Measure: Adverse events and serious adverse events

Time: 30 days

4 Sofosbuvir Containing Regimens in Treatment of COVID 19 Patients: A Randomized Controlled Trial.

efficacy and safety of Sofosbuvir containing regimens in treatment of COVID-19 Egyptian patients,

NCT04497649 Covid19 Drug: Sofosbuvir Drug: Daclatasvir Drug: Ribavirin Drug: Ledipasvir

Primary Outcomes

Description: The number of patients with improvement or mortality

Measure: Number of patients with improvement or mortality

Time: 1 month


No related HPO nodes (Using clinical trials)