Name (Synonyms) | Correlation | |
---|---|---|
drug826 | Daclatasvir Wiki | 0.58 |
drug1550 | Lactoferrin Wiki | 0.50 |
drug2866 | Temporarily holding the RAAS inhibitor [intervention] Wiki | 0.50 |
drug3467 | sofosbuvir Wiki | 0.50 |
drug2656 | Sofosbuvir Wiki | 0.50 |
drug1556 | Ledipasvir Wiki | 0.50 |
drug1784 | Moxibustion plus Cupping Wiki | 0.50 |
drug2330 | RAAS inhibitor [continued standard of care] Wiki | 0.50 |
drug1437 | Interferon beta-1b Wiki | 0.35 |
drug1434 | Interferon Beta-1B Wiki | 0.29 |
drug1605 | Lopinavir/ritonavir Wiki | 0.16 |
drug2311 | Questionnaire Wiki | 0.10 |
Name (Synonyms) | Correlation | |
---|---|---|
D002386 | Cataract NIH | 0.50 |
D003289 | Convalescence NIH | 0.22 |
D002318 | Cardiovascular Diseases NIH | 0.09 |
D007239 | Infection NIH | 0.03 |
D045169 | Severe Acute Respiratory Syndrome NIH | 0.02 |
D018352 | Coronavirus Infections NIH | 0.02 |
Name (Synonyms) | Correlation | |
---|---|---|
HP:0000518 | Cataract HPO | 0.50 |
HP:0001626 | Abnormality of the cardiovascular system HPO | 0.09 |
There are 4 clinical trials
A combination of lopinavir/ ritonavir, ribavirin and interferon beta-1b will expedite the recovery, suppress the viral load, shorten hospitalisation and reduce mortality in patients with 2019-n-CoV infection compared with to lopinavir/ ritonavir
Description: Time to negative NPS 2019-n-CoV RT-PCR
Measure: Time to negative NPS Time: Up to 1 monthDescription: Time to negative saliva 2019-n-CoV RT-PCR
Measure: Time to negative saliva Time: Up to 1 monthDescription: Time to NEWS of 0
Measure: Time to clinical improvement Time: Up to 1 monthDescription: Length of hospitalisation
Measure: Hospitalisation Time: Up to 1 monthDescription: 30-day mortality
Measure: Mortality Time: Up to 1 monthDescription: Cytokine/ chemokine changes
Measure: Immune reaction Time: up to 1 monthDescription: Adverse events during treatment
Measure: Adverse events Time: up to 1 monthDescription: Time to negative NPS, saliva, urine and stool 2019-n-CoV RT-PCR
Measure: Time to negative all clinical specimens Time: up to 1 monthSofosbuvir with and without ribavirin in treatment of COVID 19 Egyptian patients
Description: The total number of patients with response to treatment
Measure: Number of patients with response to treatment Time: 1 monthAs of 1 July 2020, more than 10 million people been confirmed to have infected by SARS-CoV-2, resulting in more than 500,000 deaths. No specific antiviral treatment for the SARS-CoV-2 is currently available, but existing medication could be repurposed. The investigators therefore propose to conduct an open-label randomized controlled trial on a short course of interferon β-1b and ribavirin combination treatment for patients hospitalized for COVID-19 infection.
Description: Time to complete alleviation of symptoms as defined by NEWS2 of 0 maintained for 24 hours
Measure: Clinical symptoms alleviation Time: 7 daysDescription: Length of hospitalisation
Measure: Hospitalisation Time: 14 daysDescription: Time to negative nasopharyngeal swab and throat saliva viral load by RT-PCR
Measure: Time to negative viral load Time: 7 daysDescription: Cytokine/ chemokine changes
Measure: Inflammatory changes Time: 7 daysDescription: One month mortality rate
Measure: Mortality Time: 30 daysDescription: Adverse events and serious adverse events within 30 days of treatment
Measure: Adverse events and serious adverse events Time: 30 daysefficacy and safety of Sofosbuvir containing regimens in treatment of COVID-19 Egyptian patients,
Description: The number of patients with improvement or mortality
Measure: Number of patients with improvement or mortality Time: 1 month