CovidResearchTrials by Shray Alag


CovidResearchTrials Covid 19 Research using Clinical Trials (Home Page)


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Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (1)


Name (Synonyms) Correlation
drug2580 Self-guided exercises Wiki 1.00

Correlated MeSH Terms (1)


Name (Synonyms) Correlation
D018352 Coronavirus Infections NIH 0.04

Correlated HPO Terms (0)


Name (Synonyms) Correlation

There is one clinical trial.

Clinical Trials


1 Home Based Covid-19 Rehabilitation Program: Pilot Clinical Trial

Our aim is to conduct a pilot single-blind randomized controlled trial to examine the preliminary efficacy of a 14 day app-based pulmonary and mobility focused rehabilitation program (intervention arm) versus a self-guided exercise program (active control arm) on pulmonary and functional outcomes in 100 patients tested for COVID-19 infection and isolated at home.

NCT04406532 Covid-19 Behavioral: PT-Pal Behavioral: Self-guided exercises

Primary Outcomes

Description: The SGRQ is a valid instrument for measuring pulmonary function in patients with respiratory disease, with a total score and scores for symptom, physical activity, and impact domains (range 0 to 100; higher scores worse). The minimum clinically important difference is 4 points. The questionnaire has excellent reliability and validity compared to gold standard pulmonary function tests.

Measure: Change in pulmonary function (St George's Respiratory questionnaire: SGRQ)

Time: baseline, at day 7 and at day 14

Description: The AM-PAC was developed to examine basic mobility and daily activity functional activities important to adults. It is a validated measure of patient-reported functional limitation in 3 domains: basic mobility, daily activities, and applied cognition. It is endorsed by the National Quality Forum as a functional status quality metric.

Measure: Change in physical function (Activity Measure for Post-Acute Care: AM-PAC)

Time: baseline, at day 7 and at day 14

Secondary Outcomes

Description: Patient asked to take a deep breath while at rest and to hold it (Normal >25 s). Test monitored by video (Zoom, PT-Pal).

Measure: Change in pulmonary function (Sabrasez single breath count)

Time: baseline, at day 7 and at day 14

Description: Participants will be given a peak flow meter at recruitment, and taught how to use it by research staff over video.

Measure: Change in pulmonary function (Peak flow tests)

Time: baseline, at day 7 and at day 14

Description: This timed test assesses strength, balance and endurance. Test monitored by video (Zoom, PT-Pal).

Measure: Change in physical function (5 times site to stand test)

Time: baseline, at day 7 and at day 14

Description: Self-report or information from medical staff.

Measure: Health events (emergency room visits and hospitalizations)

Time: baseline to day 14

Description: Anxiety symptoms reported on the BAI. Higher scores indicate more anxiety.

Measure: Change in psychological measures (Beck Anxiety Inventory: BAI)

Time: baseline, at day 7 and at day 14

Description: Depressive symptoms reported on the CES-D. Higher score indicate more depressive symptoms.

Measure: Change in psychological measures (Center for Epidemiologic Studies Depression Scale: CES-D)

Time: baseline, at day 7 and at day 14

Description: Number of sessions completed using app in the intervention arm. Controls periodically interviewed.

Measure: Feasibility (Adherence)

Time: baseline to day 14

Description: Survey of satisfaction with exercise programs.

Measure: Feasibility (Acceptability)

Time: baseline to day 14


No related HPO nodes (Using clinical trials)