Name (Synonyms) | Correlation | |
---|---|---|
drug188 | Amiodarone Wiki | 1.00 |
drug808 | Cytokine Adsorption Wiki | 1.00 |
Name (Synonyms) | Correlation | |
---|---|---|
D055371 | Acute Lung Injury NIH | 0.10 |
D012127 | Respiratory Distress Syndrome, Newborn NIH | 0.09 |
D012128 | Respiratory Distress Syndrome, Adult NIH | 0.08 |
D045169 | Severe Acute Respiratory Syndrome NIH | 0.05 |
D018352 | Coronavirus Infections NIH | 0.04 |
Name (Synonyms) | Correlation |
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There is one clinical trial.
There is an urgent need for effective therapies against the novel COVID-19 virus. Studies have shown that amiodarone and verapamil can interfere with coronavirus entry and amplification by blocking ion channels. ReCOVery-SIRIO is a randomized study to investigate amiodarone or verapamil compared with usual care in symptomatic patients hospitalized with confirmed COVID-19 infection.
Description: Time to first occurrence of clinical improvement assessed on a seven category scale ranging from 1 to 7
Measure: Clinical improvement Time: Randomization to day 15Description: Time to first occurrence of clinical improvement assessed on a seven category scale ranging from 1 to 7
Measure: Clinical improvement Time: Randomization to day 7 and 28Description: assessed on a seven category scale ranging from 1 to 7
Measure: Mean change in the 7-point ordinal scale Time: Randomization to day 7,15 and 28Description: Individual endpoint
Measure: Mortality Time: Randomization to day 28Description: Defined as body temperature (≤36.6°C [axilla], or ≤37.2 °C [oral], or ≤37.8°C [rectal]) for at least 48 hours without antipyretics or until discharge, whichever is sooner.
Measure: Time to resolution of fever Time: Randomization to day 28Description: Composite endpoint
Measure: Clinical improvement or fever resolution Time: Randomization to day 7,15 and 28Description: defined as atrial fibrillation, supraventricular or ventricular tachycardia requiring treatment
Measure: Tachyarrhythmias Time: Randomization to day 28Description: Composite endpoint
Measure: Mortality or tachyarrhythmias Time: Randomization to day 28Description: Clinical improvement assessed on a seven category scale ranging from 1 to 7.
Measure: Time to clinical improvement from admission using the 7-point ordinal scale Time: Randomization to day 28Description: The National Early Warning Score (NEWS2) score. A Higher score is worse.
Measure: Change in NEWS2 score Time: Randomization to day 7 and 15Description: oxygenation index defined as quotient of partial pressure of oxygen in arterial blood (PaO2, in mmHg) and fraction of inspired oxygen (FiO2)
Measure: PO2/FIO2 Time: Randomization to day 7 and 15Description: Assessed on a modified seven category scale ranging from 1 to 7
Measure: Clinical improvement Time: Randomization to day 15