Name (Synonyms) | Correlation | |
---|---|---|
D000544 | Alzheimer Disease NIH | 0.35 |
D060825 | Cognitive Dysfunction NIH | 0.22 |
Name (Synonyms) | Correlation | |
---|---|---|
HP:0002511 | Alzheimer disease HPO | 0.35 |
HP:0001268 | Mental deterioration HPO | 0.22 |
There are 2 clinical trials
The aging US population threatens to overwhelm our healthcare infrastructure, especially since the rate of Alzheimer's disease (AD) alone is expected to triple in the coming decades. Memory cause functional impairment, reduced quality of life, increased caregiver burnout, and eventual institutionalization. The diagnosis of mild cognitive impairment (MCI) identifies those with memory deficits but who remain relatively independent in everyday life. MCI provides a window for interventions that target memory functioning. The proposed study focuses specifically on a groundbreaking combination of mnemonic rehabilitation and non-invasive brain stimulation. The main idea is that brain stimulation can enhance functioning in the specific brain regions/networks, thereby increasing the patients' ability to benefit from different types of memory rehabilitation. This will be a randomized, double-blind study (active vs. fake brain stimulation), that provides multiple treatment session. Outcome will be examined using both laboratory-based and real-world memory testing as well as brain imaging. This first-of-its-kind study has the potential to meaningfully translate more "basic" science findings into neuroanatomically targeted and functionally meaningful treatments for our aging population.
Description: Changes in task related and resting state BOLD activation.
Measure: Functional MRI Time: 3 monthsDescription: Performance measured using percent correct
Measure: Face-name memory test performance Time: change from baselineDescription: Performance measured using deviation from target position
Measure: Object Location Association memory test performance Time: change from baselineDescription: Changes in task related and resting state BOLD activation.
Measure: fMRI Time: change from baseline to 3 monthsDescription: Performance measured using percent correct
Measure: Face-name memory test performance Time: change from baseline to 3 monthsDescription: Performance measured using deviation from target position
Measure: Object Location Association memory test performance Time: change from baseline to 3 monthsDescription: Performance on prose (medical instructions) and spatial (navigation) memory tasks
Measure: Objective memory test performance Time: 3 monthsDescription: Changes on the Multifactorial Memory Questionnaire
Measure: Subjective memory test performance on the MMQ Time: 3 monthsDescription: Performance on prose (medical instructions) and spatial (navigation) memory tasks
Measure: Objective memory test performance Time: change from baseline to 3 monthsDescription: Changes on the Multifactorial Memory Questionnaire
Measure: Subjective memory test performance on the MMQ Time: change from baseline to 3 monthsDescription: Planned analyses to examine patient specific characteristics that affect treatment efficacy and would be vital for clinical translation at the individual patient level. These include: Neuropsychological test scores, brain volumes/cortical thickness, and other possible MRI factors.
Measure: Planned (tertiary) analyses of patient-specific characteristics that affect treatment outcome Time: post treatment (within ~ 96 hours) & 3 monthsThe aging US population threatens to overwhelm our healthcare infrastructure, especially since the rate of Alzheimer's disease (AD) alone is expected to triple in the coming decades. Memory cause functional impairment, reduced quality of life, increased caregiver burnout, and eventual institutionalization. The diagnosis of mild cognitive impairment (MCI) identifies those with memory deficits but who remain relatively independent in everyday life. MCI provides a window for interventions that target memory functioning. The proposed study focuses specifically on a groundbreaking combination of mnemonic rehabilitation and non-invasive brain stimulation. The main idea is that brain stimulation can enhance functioning in the specific brain regions/networks, thereby increasing the patients' ability to benefit from different types of memory rehabilitation. This will be a randomized, double-blind study (active vs. fake brain stimulation), that provides multiple treatment session. Outcome will be examined using both laboratory-based and real-world memory testing as well as brain imaging. This first-of-its-kind study has the potential to meaningfully translate more "basic" science findings into neuroanatomically targeted and functionally meaningful treatments for our aging population.
Description: Changes in task related and resting state BOLD activation.
Measure: Functional MRI Time: 3 monthsDescription: Performance measured using percent correct
Measure: Face-name memory test performance Time: change from baselineDescription: Performance measured using deviation from target position
Measure: Object Location Association memory test performance Time: change from baselineDescription: Changes in task related and resting state BOLD activation.
Measure: fMRI Time: change from baseline to 3 monthsDescription: Performance measured using percent correct
Measure: Face-name memory test performance Time: change from baseline to 3 monthsDescription: Performance measured using deviation from target position
Measure: Object Location Association memory test performance Time: change from baseline to 3 monthsDescription: Performance on prose (medical instructions) and spatial (navigation) memory tasks
Measure: Objective memory test performance Time: 3 monthsDescription: Changes on the Multifactorial Memory Questionnaire
Measure: Subjective memory test performance on the MMQ Time: 3 monthsDescription: Performance on prose (medical instructions) and spatial (navigation) memory tasks
Measure: Objective memory test performance Time: change from baseline to 3 monthsDescription: Changes on the Multifactorial Memory Questionnaire
Measure: Subjective memory test performance on the MMQ Time: change from baseline to 3 monthsDescription: Planned analyses to examine patient specific characteristics that affect treatment efficacy and would be vital for clinical translation at the individual patient level. These include: Neuropsychological test scores, brain volumes/cortical thickness, and other possible MRI factors.
Measure: Planned (tertiary) analyses of patient-specific characteristics that affect treatment outcome Time: post treatment (within ~ 96 hours) & 3 months