Name (Synonyms) | Correlation | |
---|---|---|
drug1881 | Nitric Oxide-Sessions Wiki | 1.00 |
drug1879 | Nitric Oxide-Continuous and Sessions Wiki | 1.00 |
Name (Synonyms) | Correlation | |
---|---|---|
D000860 | Hypoxia NIH | 0.21 |
D011024 | Pneumonia, Viral NIH | 0.12 |
D011014 | Pneumonia NIH | 0.06 |
D045169 | Severe Acute Respiratory Syndrome NIH | 0.05 |
D018352 | Coronavirus Infections NIH | 0.04 |
Name (Synonyms) | Correlation | |
---|---|---|
HP:0012418 | Hypoxemia HPO | 0.21 |
HP:0002090 | Pneumonia HPO | 0.06 |
There is one clinical trial.
The pathophysiology of ARDS is linked to an uncontrolled inflammatory response at the level of alveolo-capillary membrane, mediated by neutrophils and mononuclear cells. The complement system and anaphylatoxin C5a have shown central role in the recruitment of these pro-inflammatory cells and more broadly in the genesis of cytokinic storm syndrome. C5a acts via receptors C5aR and C5L2. This is a preliminary study aimed at studying the expression of the C5a receptor on myeloid cells in peripheral blood of patients with ARDS secondary to COVID-19. This study has of primary objective to show there is an overexpression of the C5a receptor in patients with ARDS secondary to COVID-19 compared to control patients (patients with COVID-19 without respiratory distress and healthy volunteers). The medium-term objective is to develop a clinical trial to test the effectiveness of anti-C5aR antibody in this condition.
Description: The endpoint is the expression of the C5a receptor (C5aR) in peripheral blood myeloid cells, expressed as a percentage of cells expressing C5a receptor and as median fluorescence intensity (MFI), during the first 72 hours of patient management in resuscitation unit.
Measure: Show an overexpression of C5a receptor in patients with ARDS secondary to COVID-19 compared to control patients (patients with COVID-19 without respiratory distress and healthy volunteers). Time: 72 hours