CovidResearchTrials by Shray Alag

CovidResearchTrials Covid 19 Research using Clinical Trials (Home Page)

Biological dataWiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (1)

Name (Synonyms) Correlation
drug681 Clinical data Wiki 0.82

Correlated MeSH Terms (3)

Name (Synonyms) Correlation
D007238 Infarction NIH 0.53
D009203 Myocardial Ischemia NIH 0.41
D009205 Myocarditis NIH 0.25

Correlated HPO Terms (2)

Name (Synonyms) Correlation
HP:0001658 Myocardial infarction HPO 0.41
HP:0012819 Myocarditis HPO 0.25

There are 2 clinical trials

Clinical Trials

1 MYocardial DOmmages Related to COVID-19

Myocardial injury, as assessed by elevation of cardiac troponins (Tnc), is frequent among patients with COVID-19. Although rare autopsy cases reported COVID-19 related myocardial inflammation, the origin of Tnc elevation is unknown to date. Several cardiac causes, such as myocarditis, non-ischemic myocardial injury (NIMI), or myocardial infarction (MI) may lead to Tnc kinetic. Our work will test the hypothesis that during SARS-Cov2 infection, the elevation of cardiac biomarkers could be linked to the occurrence of myocarditis.

NCT04498065 Covid19 Non Ischemic Myocardial Injury Myocardial Infarction Myocarditis Troponin Elevation Biological: Biological data Other: Clinical data
MeSH:Myocardial Infarction Myocarditis Infarction
HPO:Myocardial infarction Myocarditis

Primary Outcomes

Description: Myocardtitis diagnosis in patients COVID+ and troponin+

Measure: characterize the myocardial damage associated with CoV-2 SARS infection

Time: Through study completion, an average of 1 year

2 EPIdemiological Approaches to the Cardiovascular Consequences of COVID-19

The COVID-19 pandemic highlights the importance of the prognosis of co-morbidities, such as coronary artery disease, which significantly increase the risk of mortality in patients infected with SARS-CoV2. Investigators have recently studied the complex links between respiratory infections, particularly pneumonia, and type 2 myocardial infarction (MI) in many respects. The etiology of type 2 MI is based on an imbalance of myocardial oxygen supply/need in the absence of rupture/erosion of atheromatous plaques. Based on the RICO survey data, the investigators investigated whether COVID-19-related sepsis and/or respiratory failure could be an underlying mechanism of MI2.

NCT04498091 Acute Myocardial Infarction Biological: Biological data Other: Clinical data
MeSH:Myocardial Infarction Infarction
HPO:Myocardial infarction

Primary Outcomes

Measure: Characterizing type 2 myocardial infarction associated with CoV-2 SARS infection

Time: Through study completion, an average of 1 year

Related HPO nodes (Using clinical trials)

HP:0001658: Myocardial infarction
Genes 79
MYH9 JAK2 IL12A CYP27A1 HLA-B BSCL2 LIMK1 RFC2 LDLR LPL RAF1 MEFV SH2B3 ABCA1 WRN GTF2I SCNN1A TBL2 CYP27A1 HLA-B MEFV ABCG8 ELN BRAF C4A IL12A-AS1 CEP19 CAV1 IKZF1 UBAC2 MLX THOC2 CTNNB1 PTPN11 SCNN1G MEF2A IL10 CLIP2 IL12B ABCC6 MYH9 ABCA1 LDLRAP1 GLA STAT4 SH2B3 CFTR SLC2A10 IL23R CBS ERAP1 BAZ1B LMNA PCSK9 CCR1 BRAF FOS APOB KLRC4 JAK2 AGPAT2 TET2 LRP6 BCHE ABCG5 TLR4 HLA-B DYRK1B SCNN1B GTF2IRD1 TP53 PPARG CAVIN1 MPL ENPP1 PIGA FAS CALR HGD
Protein Mutations 13
A1166C C344T C807T G1051A G20210A G3514C G98T I843S L33P M235T Q192R Q222R V34L
SNP 11
rs10153820 rs16969968 rs1761667 rs4244285 rs4986893 rs6434222 rs6971 rs7586970 rs7903146 rs8069645 rs8176528
HP:0012819: Myocarditis
Genes 4
SLC2A10 GPX4 PPA2 GPX4
Protein Mutations 0
SNP 0