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cleavage-stage embryo transferWiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (1)

Name (Synonyms) Correlation
drug3203 blastocyst-stage embryo transfer Wiki 1.00

Correlated MeSH Terms (1)

Name (Synonyms) Correlation
D007246 Infertility NIH 0.38

Correlated HPO Terms (1)

Name (Synonyms) Correlation
HP:0000789 Infertility HPO 0.38

There is one clinical trial.

Clinical Trials

1 Cumulative Live Birth Rates After Cleavage-stage Versus Blastocyst-stage Embryo Transfer: A Multicenter, Prospective, Randomized Controlled Trial

The aim of this RCT is to compare differences in the efficacy and safety between cleavage-stage embryo transfer and blastocyst-stage embryo transfer in IVF/ICSI treatment cycle, taking into account of subsequent vitrified embryo transfers. Subjects with 3 or more transferrable cleavage embryos will be randomized to the cleavage-stage or blastocyst-stage embryos transfer group. The primary outcome is cumulative live birth rate (CLBR) per patient until the first live birth from one initiated oocyte retrieval cycle, calculated using outcomes from the first three embryo transfers within 1 year after randomization.

NCT03152643 Infertility Procedure: blastocyst-stage embryo transfer Procedure: cleavage-stage embryo transfer
MeSH:Infertility
HPO:Infertility

Primary Outcomes

Description: Cumulative live birth rate (CLBR) is defined the first live birth per patient from one initiated oocyte retrieval cycle(Calculated using outcomes from the first three embryo transfers within 1 year after randomization). Live birth is defined as delivery of any neonate ≥24 weeks gestation with heart beat and breath.

Measure: cumulative live birth rate

Time: 30 months

Secondary Outcomes

Description: Biochemical pregnancy is defined as a serum β-HCG level of at least 25 IU/L 14 days after embryo transfer.

Measure: biochemical pregnancy rate

Time: 30 months

Description: Clinical pregnancy is defined by the presence of intrauterine gestation sacs at 30-35 days after embryo transfer.

Measure: clinical pregnancy rate

Time: 30 months

Description: Ongoing pregnancy is defined as a viable pregnancy at 12 weeks gestation.

Measure: ongoing pregnancy rate

Time: 30 months

Description: Pregnancy loss is defined as a pregnancy that results in a spontaneous abortion or therapeutic abortion that occurred throughout pregnancy.

Measure: Pregnancy loss rate

Time: 30 months

Description: Number of patients with moderate or severe OHSS/ number of COS cycles.

Measure: moderate or severe OHSS rate

Time: 12 months

Description: diagnosed by ultrasound examination or laparoscopic surgery visualizing more than or equal to 1 gestational sacs outside the uterus or by abnormally increasing serum hCG level without sonographic visualization and the absence of chorionic villi inside the uterus after uterine curettage, which was treated by methotrexate.

Measure: ectopic pregnancy

Time: 24 months

Description: the ratio of males to females in the newborns

Measure: sex ratio

Time: 30 months

Description: Number of multiple pregnancies / number of clinical pregnancies.

Measure: multiple pregnancy

Time: 30 months

Description: Number of pregnancies with complications / number of pregnancies; ;number of live births with neonatal complications / number of live births

Measure: incidence of obstetric and perinatal complications

Time: 30 months

Description: structural or functional anomalies that occur during intrauterine life and can be identified prenatally, at birth or later in life.

Measure: congenital anomalies

Time: 30 months

Description: the number of gestational sacs detected with sonography at 6 weeks of pregnancy/the number of embryos transferred

Measure: implantation rate

Time: 30 months

Description: Weight of newborns at delivery

Measure: Birth weight

Time: 30 months

Related HPO nodes (Using clinical trials)

HP:0000789: Infertility
Genes 212
CCDC39 RSPH1 PLIN1 CATSPER2 CCNO SPEF2 SPAG1 FLRT3 DAZ4 MCIDAS CCDC141 CATSPER2 TSGA10 ZP3 GBA2 LHCGR DNAH1 MAP3K1 ZFPM2 WWOX PWAR1 AXL CFAP221 STRC PROP1 DNAAF1 RPGR WEE2 STK36 DNAH9 DNAAF5 PROP1 RSPH3 BRDT ADGRG2 DHX37 OFD1 RSPH4A CFAP251 POLR3B HSD17B3 NME8 GAS8 CFTR NPAP1 ZP2 CCDC65 CFAP298 CFAP300 DAZ2 CFTR CDC14A PPP2R3C AR CYP19A1 SPEF2 AMHR2 SEPTIN12 TUBB8 ZMYND10 GCM2 DNAAF4 RNF216 SRY RSPH1 CCDC39 ARMC4 CFAP44 DNAI2 TTC29 FCGR2A CATSPER2 TEX14 NEK10 NDN ZP1 DNAI1 SOX3 TGFB1 TSPY1 HUWE1 AURKC DNAAF6 CCDC103 DDX3Y DNAAF4 GATA4 SPATA16 HERC2 DNAH1 MAGEL2 CFAP300 SNORD115-1 MKRN3-AS1 MEI1 PADI6 SOHLH1 SLC26A8 FOXJ1 NR3C1 GAS2L2 PMFBP1 MAP2K1 CCDC151 SUN5 STRC DUSP6 DNAL1 CATSPER1 SNRPN TLE6 LMNA FEZF1 FGF17 ZMYND10 AR VAMP7 PRLR SRA1 RSPH9 GAS2L2 WDR11 AMH USP9Y PMFBP1 HESX1 GNRHR STRC ARMC2 DNAH5 CDH23 TTC12 GLI2 SRY CCDC40 PATL2 FSHB AR SOX9 BRAF H6PD FOXL2 MKRN3 DNAI2 FOXA2 WT1 NANOS1 DHH LRRC6 DNAI1 DNAH1 DNAJB13 PTPN11 CCDC40 DNAH9 SNORD116-1 FSIP2 HJV RBMY1A1 DAZ1 NR5A1 GNRH1 CFAP43 DNAJB13 NR3C1 LHX4 DNAAF3 TTC25 CEP19 PRLR DNAAF2 PGR IL17RD NR0B1 DRC1 DMRT3 PWRN1 GBA2 RSPH3 SEMA3E LRRC6 DAZ3 SYCP2 QRICH2 CFAP298 STUB1 DNAAF5 CCNO FANCA SPRY4 OTX2 HYDIN CDH23 CTNS CCDC114 LRRC56 IPW ZMPSTE24 MEIOB KLHL10 DNAAF3 DNAAF1 PLCZ1 PANX1 HSD17B3 SUN5 TEX11 AK7 POU1F1 USP8 DNAAF6 DNAH11
Protein Mutations 7
C677T G1691A G71A L24E N312S N680S S680N
SNP 5
rs12676 rs4986938 rs6165 rs6166 rs66554220