Correlated Drug Terms (2)

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	Name (Synonyms)	Correlation
drug2846	Telehealth CBT Wiki	1.00
drug2692	Standard care Wiki	0.35

Correlated MeSH Terms (1)

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	Name (Synonyms)	Correlation
D001008	Anxiety Disorders NIH	0.15

Correlated HPO Terms (0)

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	Name (Synonyms)	Correlation

Primary Outcomes

Description: Composite clinical outcome with oxygen therapy dependency time (in days) or hospitalization time (in days) after randomization.

Measure: Composite clinical outcome with oxygen therapy dependency time or hospitalization time

Time: 1-28 days

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Secondary Outcomes

Description: We will evaluate the presence or absence of symptoms related to the use of propolis through a questionnaire.

Measure: Percentage of participants with adverse events during the use of propolis

Time: 1-28 days

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Description: Assess the degree of acute kidney injury according to KDIGO (through serum creatinine or urine output).

Measure: Rate and severity of acute kidney injury during the study

Time: 1-28 days

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Description: Assess need or not for renal replacement therapy.

Measure: Renal replacement therapy.

Time: 1-28 days

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Description: Describe the time needed for vasopressors in days after randomization

Measure: Rate of need for vasopressor use

Time: 1-28 days

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Description: Assess length of stay in the ICU after randomization in days

Measure: Need for intensive care unit (ICU)

Time: 1-28 days

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Description: Rate of readmission to the ICU after randomization

Measure: Intensive care unit (ICU) readmission

Time: 1-28 days

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Description: Assess the need for mechanical ventilation in days after randomization.

Measure: Invasive oxygenation time

Time: 1-28 days

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Description: Evaluate the variation in serum levels of c-reactive protein over the 7 days after randomization

Measure: Variation of plasma c-reactive protein

Time: 1-7 days

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