Correlated Drug Terms (0)

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	Name (Synonyms)	Correlation

Correlated MeSH Terms (1)

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	Name (Synonyms)	Correlation
D003693	Delirium NIH	0.50

Correlated HPO Terms (0)

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	Name (Synonyms)	Correlation

Primary Outcomes

Description: Ever Delirium: Measured using the Intensive Care Delirium Screening Checklist (ICDSC). If the patient has a positive score in the ICDSC at any point during the patient's ICU stay then the patient is considered to have delirium and qualifies for Ever Delirium. Delirium Duration: Number of days the patient has a positive score on the ICDSC. This does not have to be consecutive days.

Measure: Delirium Prevalence and Duration

Time: From date of patient enrolment to ICU discharge, an average of 6.7 days.

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Secondary Outcomes

Description: Johns Hopkins Adapted Cognitive Exam (ACE) o The Adapted Cognitive Exam is the first valid and reliable examination for the assessment and quantification of cognition in critically ill patients. It provides a useful, objective tool that can be used by any member of the interdisciplinary critical care team to support clinical assessment and research efforts.

Measure: Cognitive Function

Time: Measured within 24 hours of patient ICU admission and again after the treatment period is completed which is an average of 6.7 days.

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Description: Dates will be obtained from electronic medical charts. I.e. Sunrise Clinical Manager.

Measure: ICU length of stay

Time: ICU admission date to ICU discharge date is the time the patient will be given the treatment which is an average of 6.7 days.

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Description: The Functional Status Score for the ICU (FSS-ICU). The Functional Status Score for the ICU (FSS-ICU) is an assessment of physical function specifically designed for ICU patients. It is scored based on 5 mobility domains (rolling in bed, lying to sitting, sitting balance, sitting to standing and walking) and the level of assistance the patient requires to complete the task. Each item is out of 7, with total scores ranging from 0-35 and a high score correlating to high function. The FSS-ICU has good validity when compared to other functional measures in the ICU, it has been demonstrated to have good interrater reliability and has minimal floor and ceiling effect.

Measure: Physical Function

Time: Measured within 48 hours of ICU admission and again after the treatment period is completed which is an average of 6.7 days.

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Description: The 5 Level EQ 5D version is a standardized measure of health status developed by the EuroQol Group in order to provide a simple, generic measure of health for clinical and economic appraisal (Van Reenan & Janssen, 2015). It covers five dimensions; mobility, self-care, usual activities, pain/discomfort and anxiety/depression which are measured with one of five response options (no problems, slight problems, moderate problems, severe problems, and extreme problems). A total of 3125 possible health states is defined in this way. Each state is referred to in terms of a 5 digit code. For example, state 11111 indicates no problems on any of the 5 dimensions, while state 12345 indicates no problems with mobility, slight problems with washing or dressing, moderate problems with doing usual activities, severe pain or discomfort and extreme anxiety or depression (Reenan & Janssen, 2015, p. 9). The EQ5D-5L also includes a visual analog scale to measure health state (0-100).

Measure: Quality of Life using the EQ5D-5L (EuroQual 5 Dimensions-5 Levels). This is a health quality of life measure assessing five domains; mobility, self-care, usual activities, pain/discomfort and anxiety/depression.

Time: Measured after the treatment period is completed (within 24 hours of discharge) which is an average of 6.7 days.

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Description: Dates will be obtained from electronic medical charts. i.e. Metavision

Measure: Days of Mechanical Ventilation

Time: Measured on day 1 of mechanical ventilation through to day of extubation (cessation of mechanical ventilation), an average of 4 days.

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Description: Date of hospital admission and discharge will be obtained from electronic medical chart. i.e. Sunrise Clinical Manager.

Measure: Length of Hospital Stay

Time: Up to 6 months

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