CovidResearchTrials by Shray Alag


CovidResearchTrials Covid 19 Research using Clinical Trials (Home Page)


Awake prone positioningWiki

Developed by Shray Alag
Clinical Trial MeSH HPO Drug Gene SNP Protein Mutation


Correlated Drug Terms (3)


Name (Synonyms) Correlation
drug2715 Standard oxygen therapy Wiki 1.00
drug2809 TD-0903 Wiki 0.71
drug2122 Placebo Wiki 0.05

Correlated MeSH Terms (5)


Name (Synonyms) Correlation
D055370 Lung Injury NIH 0.20
D007249 Inflammation NIH 0.19
D055371 Acute Lung Injury NIH 0.10
D012128 Respiratory Distress Syndrome, Adult NIH 0.08
D011014 Pneumonia NIH 0.06

Correlated HPO Terms (1)


Name (Synonyms) Correlation
HP:0002090 Pneumonia HPO 0.06

There is one clinical trial.

Clinical Trials


1 Prone Positioning in Non-intubated Patients With Severe COVID-19: a Randomized Controlled Trial

Besides protective ventilation with low tidal volumes, prone positioning is a proven intervention to decrease mortality in mechanically ventilated patients with moderate-severe acute respiratory distress syndrome. However, the evidence of this strategy in awake non-intubated patients is scarce. The investigators will perform a randomized controlled trial to define if prone positioning can reduce the requirement of mechanical ventilation.

NCT04477655 Covid19 Procedure: Awake prone positioning Procedure: Standard oxygen therapy

Primary Outcomes

Measure: Intubation rate

Time: 28 days

Secondary Outcomes

Measure: Total hours of prone position at day

Time: 28 days

Measure: Total number of prone sessions at day

Time: 28 days

Measure: Hours of the longest prone session each day

Time: 28 days

Measure: Change in oxygenation 1-hour after first prone session

Time: 1 hour

Description: The change in the Ratio of Oxygen saturation to respiratory rate (ROX-index)

Measure: Change in the ROX-index 1-hour after first prone session

Time: 1 hour

Measure: Total days of prone positioning therapy

Time: 28 days

Measure: Adverse effects of prone positioning therapy

Time: 28 days

Measure: Mechanical ventilation days

Time: 28 days

Measure: Intensive care unit length of stay

Time: 28 days

Measure: Hospital length of stay

Time: 28 days

Measure: Hospital mortality

Time: 28 days


No related HPO nodes (Using clinical trials)